diclofenac allergy

Symptoms of Diclofenac Allergy

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), can cause allergic reactions in some individuals. The symptoms of diclofenac allergy may include:

• Skin rash: A swollen, raised, itchy, blistered or peeling skin rash is a common symptom of diclofenac allergy [6][9].
• Hives: Hives are another sign of an allergic reaction to diclofenac [2][5][9].
• Swelling of the face, lips, tongue, or throat: Swelling in these areas can be a sign of a severe allergic reaction [2][5][7].
• Bleeding: Bleeding from the digestive tract, such as bloody or black stools, vomiting blood or brown material, can occur due to diclofenac-induced ulcers or holes in the stomach or intestine [8][9].

Other Possible Symptoms

In addition to these symptoms, some individuals may experience:

• Urticaria: A type of skin rash characterized by itchy, raised patches [10].
• Fever: Elevated body temperature can be a sign of an allergic reaction [9].
• Sore throat: Soreness in the throat can occur due to diclofenac allergy [9].

Important Note

If you experience any of these symptoms after taking diclofenac, seek medical attention immediately. A severe allergic reaction can be life-threatening and requires prompt treatment.

References:

[1] Not applicable (description only)

[2] Context 2: Diclofenac is a nonsteroidal anti-inflammatory drug used to treat pain and inflammation associated with arthritis. Includes side effects, interactions, warnings. ... Get emergency medical help if you have signs of an allergic reaction to diclofenac (hives, difficult breathing, swelling in your face or throat) ...

[3] Context 3: Hypersensitivity reactions against nonsteroidal antiinflammatory drugs (NSAIDs) like diclofenac (DF) can manifest as Type I-like allergic reactions including systemic anaphylaxis. However, except for isolated case studies experimental evidence for an IgE-mediated pathogenesis of DF-induced hypersensitivity is lacking.

[4] Not applicable (description only)

[5] Context 5: Tips ... (urticaria), or other allergic-type reactions in the past after taking aspirin or other NSAIDs (like ibuprofen), do not take diclofenac.

[6] Context 6: Description. Diclofenac is used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure osteoarthritis and will help you only as long as you continue to use it. ... This medicine may cause a serious allergic reaction called ...

[7] Context 7: Voltaren (diclofenac) is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Includes Voltaren side effects, interactions and indications. ... You should not use Voltaren if you are allergic to diclofenac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

[8] Context 8: Diclofenac is a non-opioid analgesic used to relieve pain, fever, and inflammatory diseases. Learn about its uses, dosage, drug warnings, side effects, precautions, drug interactions, and more. ... Allergic Reactions: A severe allergic reaction to this drug is rare, but when you notice any symptoms of a serious allergic reaction, reach a doctor ...

[9] Context 9

Symptoms of Diclofenac Allergy

Diclofenac allergy can manifest in various ways, and it's essential to recognize the signs and symptoms to seek medical attention promptly.

• Skin reactions: A person experiencing an allergic reaction to diclofenac may develop a rash that is swollen, raised, itchy, blistered, or peeling [2].
• Respiratory issues: Difficulty breathing, swelling of the face or throat, and hives are common symptoms of an allergic reaction to diclofenac [3].
• Cardiovascular concerns: Chest pain, shortness of breath, and weakness in one part of the body can be indicative of a severe allergic reaction [4].
• Gastrointestinal problems: Bloody or black, tar-like stools, vomiting blood or brown material, and abdominal pain are potential symptoms of an allergic reaction to diclofenac [6].

Other Possible Symptoms

In addition to these symptoms, a person experiencing an allergic reaction to diclofenac may also exhibit:

• Fever
• Sore throat
• Burning eyes
• Skin pain
• Redness of the skin

It's crucial to seek emergency medical help if you or someone else experiences any of these symptoms after taking diclofenac.

References: [1] Not applicable (this information is not present in the context) [2] Context #2 [3] Context #3 [4] Context #4 [5] Not applicable (this information is not present in the context) [6] Context #6

Diagnostic Tests for Diclofenac Allergy

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), can cause allergic reactions in some individuals. While there is no reliable blood or skin test to confirm or exclude allergy to aspirin and NSAIDs, including diclofenac, several diagnostic tests can help identify an allergy to this medication.

• Skin Tests: Classic diagnostic allergy testing using skin tests, such as the skin prick test, intradermal test, and patch test, is only useful in rare cases of type IV (SNIDR) and type I (SNIUAA) reactions [1].
• IgE Antibody Testing: Detection of IgE antibodies indicates an increased likelihood of allergy to diclofenac. This test measures the level of IgE antibodies to detect the cause of allergies [8].
• Oral Challenge Tests: Oral challenge tests represent the gold standard in the diagnosis of drug hypersensitivity, including NSAID allergy [7].

Other Considerations

It's essential to note that blood and urine tests may be needed to check for unwanted effects of diclofenac, such as an increased risk of heart attack or stroke [9]. Additionally, a clinical history and skin or provocation tests can help diagnose NSAIDs hypersensitivity [3].

References

[1] S Wöhrl et al. (2018) Classic diagnostic allergy testing using skin tests is only useful in rare cases of type IV (SNIDR) and type I (SNIUAA) reactions.

[2] A Harrer et al. (2010) Characterization included skin tests, determination of total serum IgE and allergen-specific IgE against common aeroallergens.

[3] L Palma-Carlos et al. (2008) Rationale for diagnosing NSAIDs hypersensitivity relies on clinical history and skin or provocation tests.

[7] C Beutner et al. (2022) Oral challenge tests represent the gold standard in the diagnosis of drug hypersensitivity, including NSAID allergy.

[8] Detection of IgE antibodies indicates an increased likelihood of allergy to diclofenac (Pain Killer) drug that may be responsible for eliciting signs and symptoms.

[9] Blood and urine tests may be needed to check for unwanted effects. This medicine may raise your risk of having a heart attack or stroke.

Treatment Options for Diclofenac Allergy

If you are allergic to diclofenac, it's essential to discontinue its use and seek medical attention if symptoms persist or worsen. Here are some treatment options mentioned in the search results:

• Discontinuation of topical application: Discontinuing the use of diclofenac is the best therapeutic approach for patients with an allergic reaction [8].
• Non-corticosteroid ointments: Alternative treatments like betamethasone valerate 0.1% ointment or tacrolimus 1% ointment can be used safely to alleviate symptoms [2, 10].

However, it's crucial to note that diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) and should not be used as a treatment for allergic reactions. If you experience any symptoms of an allergic reaction, such as itching sensation, urticarial rash, mild hypotension, or blood oxygen desaturation, seek immediate medical attention [7].

Important Considerations

• Anaphylaxis: Diclofenac can cause a serious allergic reaction called anaphylaxis, which requires immediate medical attention [3].
• Topical application guidelines: When using Voltaren Gel (diclofenac topical gel), wait for at least 1 hour after applying the medicine before showering, bathing, or washing the affected area [9].

It's essential to consult a healthcare professional for personalized advice on treating diclofenac allergy. They can provide guidance based on your specific symptoms and medical history.

References:

[1] Not applicable [2] CB Lynde (2009) - Cited by 14 [3] Jan 31, 2024 - Anaphylaxis warning [7] T Sanuki (2010) - Cited by 1 [8] SJ Gulin (2016) - Cited by 20 [9] Jan 31, 2024 - Topical application guidelines [10] CB Lynde (2009) - Cited by 14

Differential Diagnosis of Diclofenac Allergy

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), can cause allergic reactions in some individuals. When diagnosing an allergy to diclofenac, it's essential to consider other possible causes of the symptoms. Here are some differential diagnoses to consider:

• Infection: Skin lesions or rashes caused by infection should be ruled out before attributing them to diclofenac allergy.
• Inflammatory conditions: Conditions like eczema, psoriasis, or dermatitis can mimic allergic reactions and should be considered in the differential diagnosis.
• Aeroallergens: All