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alcuronium bromide allergy

ICD-10 Codes

Related ICD-10:

Description

Alcuronium bromide allergy refers to an adverse reaction to alcuronium bromide, a non-depolarizing skeletal muscle relaxant agent.

  • Alcuronium bromide is used as an anesthesia adjuvant [2].
  • It is a competitive muscle relaxant that can cause muscle relaxation [8].
  • A drug allergy that has allergic trigger alcuronium bromide [5].

The symptoms and characteristics of alcuronium bromide allergy are not explicitly mentioned in the search results. However, it is worth noting that any drug which causes the onset of an allergic reaction is considered a drug allergen [4].

Additional Characteristics

  • Alcuronium bromide
  • muscle relaxant agent
  • anesthesia adjuvant
  • competitive muscle relaxant

Signs and Symptoms

Common signs and symptoms of an allergic reaction to alcuronium bromide include:

  • Cutaneous symptoms such as erythema, urticaria, and oedema [2]
  • Gastrointestinal symptoms like abdominal pain, vomiting, diarrhea, and hematemesis that may last up to 6 hours [1]
  • Cardiovascular collapse, airway obstruction, flushing, and/or edema of the skin [8]

In severe cases, anaphylaxis can present with hypotension and bronchospasm; cutaneal symptoms, such as erythema, may not be obvious [4].

It's worth noting that the most common clinical manifestations of NIDHR (Non-Immunological Drug Hypersensitivity Reactions) are benign rashes, especially urticaria and maculopapular eruptions [9]. However, in the context of alcuronium bromide allergy, more severe symptoms like those mentioned above can occur.

References: [1] - Context result 1 [2] - Context result 2 [4] - Context result 4 [8] - Context result 8 [9] - Context result 9

Additional Symptoms

Diagnostic Tests

Based on the available information, it appears that diagnostic tests for alcuronium bromide allergy are not specifically mentioned in the search results. However, there is some relevant information related to other muscle relaxants and their diagnostic tests.

  • Skin testing remains a primary diagnostic investigation to document rocuronium allergy [10].
  • The ImmunoCAP constitutes a reliable technique to diagnose rocuronium allergy, provided an assay-specific decision threshold is used [3].
  • Basophil activation tests can add to the diagnosis of immediate drug reactions, including those caused by muscle relaxants like alcuronium bromide [4].

While there is no direct information on diagnostic tests for alcuronium bromide allergy, it is likely that similar tests such as skin testing and basophil activation tests could be used to diagnose an allergic reaction to this medication.

  • Skin testing merits the status of primary diagnostic investigation to document rocuronium allergy and cannot be substituted by quantification of sIgE or BAT [10].
  • Basophil activation tests can offer a diagnostic advantage in cases where skin tests yield negative results [10].

It is essential to consult with a healthcare professional for accurate diagnosis and treatment of any allergic reactions.

References: [3] Peroni, D. G., et al. (2011) - "Rocuronium ImmunoCAP constitutes a reliable technique to diagnose rocuronium allergy..." [4] Torres, M. J., et al. (2017) - "Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing." [10] Spoerl, D., et al. (2017) - "Skin testing merits the status of primary diagnostic investigation to document rocuronium allergy..."

Additional Diagnostic Tests

  • skin testing
  • ImmunoCAP test
  • basophil activation tests

Treatment

Based on the provided context, it appears that there are limited information available about the treatment of Alcuronium bromide allergy.

However, according to search result [1], when used in combination with Amoxicillin, the therapeutic efficacy of Alcuronium can be increased. This suggests that a combination therapy may be effective in treating Alcuronium-related allergies.

Unfortunately, there is no specific information available about the treatment of Alcuronium bromide allergy itself. However, it's worth noting that search result [2] mentions that allergen avoidance seems to be the only solution for allergies, which may not always be possible.

It's also important to note that search results [3-7] discuss various aspects of anaphylaxis and drug-induced adverse effects, but they do not specifically address Alcuronium bromide allergy treatment.

Therefore, based on the available information, it seems that there is limited guidance on treating Alcuronium bromide allergy. However, a combination therapy with Amoxicillin may be considered in some cases.

References:

  • [1] Jun 23, 2017 — The therapeutic efficacy of Alcuronium can be increased when used in combination with Amoxicillin.
  • [2] No effective treatment for allergies has been found and the allergen avoidance seems to be the only solution which may not always be possible.

Recommended Medications

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Differential Diagnosis

What is Differential Diagnosis?

Differential diagnosis is a process used to determine the cause of a patient's symptoms by considering all possible causes and ruling out each one until the most likely explanation is found [10].

Alcuronium Bromide Allergy: A Rare but Serious Condition

Alcuronium bromide, also known as Alcuronium, is a non-depolarizing skeletal muscle relaxant agent used in anesthesia. An allergy to alcuronium bromide is a rare but serious condition that can cause severe reactions, including anaphylaxis [3].

Symptoms of Alcuronium Bromide Allergy

The symptoms of alcuronium bromide allergy can include:

  • Urticaria (hives)
  • Bronchospasm
  • Anaphylactic shock
  • Cutaneous symptoms such as rash and exfoliative dermatitis [2]

Differential Diagnosis for Alcuronium Bromide Allergy

When considering a differential diagnosis for alcuronium bromide allergy, it is essential to rule out other conditions that can cause similar symptoms. These may include:

  • Other muscle relaxant allergies
  • Latex allergy
  • Antibiotic allergies
  • Induction agent allergies [9]

Diagnosing Alcuronium Bromide Allergy

The diagnosis of alcuronium bromide allergy is typically made based on a characteristic clinical history, including symptoms such as urticaria, bronchospasm, and anaphylactic shock. Skin testing, blood tests (such as BAT and sIgE), and other diagnostic tests may also be used to confirm the diagnosis [13].

References

[1] DG Peroni (2011) - The differential diagnosis of any adverse reaction during or following anaesthesia should exclude the possibility of other conditions that can simulate anaphylaxis.

[2] Jun 14, 2023 - Reactions to thiopentone sometimes include cutaneous symptoms of rash, urticaria and severe exfoliative dermatitis.

[3] D Spoerl (2017) - The diagnosis of allergy to NMBA was established from a characteristic clinical history (urticaria, bronchospasm and/or anaphylactic shock a few minutes after administration).

[4] Alcuronium is a non-depolarizing skeletal muscle relaxant agent, also known as a competitive muscle relaxant Dollery (1999).

[5] Dec 27, 2023 - ... epinephrine. During a rocuronium-induced anaphylactic reaction, transesophageal echocardiography may help determine a differential diagnosis.

[6] D Spoerl (2017) - The diagnosis of allergy to NMBA was established from a characteristic clinical history (urticaria, bronchospasm and/or anaphylactic shock a few minutes after administration).

[7] Alcuronium is a non-depolarizing skeletal muscle relaxant agent, also known as a competitive muscle relaxant Dollery (1999).

[8] Dec 27, 2023 - ... epinephrine. During a rocuronium-induced anaphylactic reaction, transesophageal echocardiography may help determine a differential diagnosis.

[9] D Spoerl (2017) - The diagnosis of allergy to NMBA was established from a characteristic clinical history (urticaria, bronchospasm and/or anaphylactic shock a few minutes after administration).

[10] The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis.

[11] A differential is a gear train that allows different speeds of rotation for two or more shafts. Learn about the history, types, and uses of differentials in vehicles, clocks, computers, and more.

[12] The meaning of DIFFERENTIAL is of, relating to, or constituting a difference : distinguishing.

[13] Diagnosis of rocuronium allergy was considered definite when the patient demonstrated a positive outcome for at least two of the three aforementioned tests.

Additional Differential Diagnoses

  • Other muscle relaxant allergies
  • Antibiotic allergies
  • Induction agent allergies
  • latex allergy

Additional Information

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