autoimmune glomerulonephritis

Autoimmune glomerulonephritis is a type of kidney disease in which the body's own immune system attacks the blood vessels of the glomeruli, the part of the kidney that filters waste and fluids from the blood [6]. This attack causes inflammation and damage to the glomeruli, leading to impaired kidney function.

The symptoms of autoimmune glomerulonephritis can vary depending on the severity of the disease. Some people may not show any symptoms at all, while others may experience symptoms such as:

• Pink or cola-colored urine due to red blood cells in the urine (hematuria)
• Foamy or bubbly urine due to excess protein in the urine
• Swelling in the legs and feet
• High blood pressure
• Fatigue

If left untreated, autoimmune glomerulonephritis can lead to kidney failure [8]. It is essential to seek medical attention if you are experiencing any of these symptoms.

Autoimmune glomerulonephritis is a complex disease that requires a comprehensive treatment plan. Treatment may involve medications such as corticosteroids and immunosuppressive agents to reduce inflammation and suppress the immune system's attack on the kidneys [4]. In some cases, dialysis or kidney transplantation may be necessary if the disease progresses to end-stage renal disease.

It is essential to note that autoimmune glomerulonephritis can also affect other parts of the body, such as the lungs. In these cases, treatment may involve medications and therapies specifically designed for lung diseases [5].

References: [4] - 4. by HJ Anders · 2023 · Cited by 79 — 'Glomerulonephritis' (GN) is a term used to describe a group of heterogeneous immune-mediated disorders characterized by inflammation of the ... [5] - 5. An autoimmune disorder that affects the kidneys and lungs, often leading to kidney failure and lung disease. [6] - 6. Nov 8, 2023 — In the disease autoimmune glomerulonephritis, the body's own immune system attacks the blood vessels of the glomeruli, the part of the kidney ... [8] - 8. Glomerulonephritis happens when the kidneys' blood filters (glomeruli) become inflamed and scarred. This can lead to kidney failure if untreated.

Autoimmune glomerulonephritis, also known as immune complex-mediated glomerulonephritis, is a type of kidney disease caused by the body's immune system attacking its own tissues. The signs and symptoms of this condition can vary from person to person but often include:

• Blood in urine (hematuria): This is one of the most common symptoms of autoimmune glomerulonephritis, where the urine may appear pink or cola-colored due to the presence of red blood cells [1].
• Foamy or bubbly urine: Excess protein in the urine can cause it to become foamy or bubbly, which is another characteristic symptom of this condition [1].
• Rash: Some people with autoimmune glomerulonephritis may experience a rash on their skin, which can be a sign of an underlying autoimmune disease [2].
• Joint pain and swelling: Inflammation caused by the immune system's attack on the kidneys can lead to joint pain and swelling in some individuals [3].
• Nausea and vomiting: As the condition progresses, people may experience nausea and vomiting due to the buildup of toxins in the body [4].
• Shortness of breath: Swelling in the legs and feet can cause fluid to accumulate in the lungs, leading to shortness of breath [5].

It's essential to note that some individuals with autoimmune glomerulonephritis may not experience

Autoimmune glomerulonephritis is a type of kidney disease that involves inflammation of the tiny filter units in the kidneys called glomeruli, caused by an abnormal immune response.

Diagnostic tests for autoimmune glomerulonephritis:

• Urinalysis: This test may show proteinuria (excess protein in the urine), hematuria (blood in the urine), or active sediment (white blood cell casts or red blood cell casts) [1].
• Blood tests: Doctors may order blood tests to check for antibodies directed against some of the body's own tissues, which can indicate an autoimmune cause for glomerulonephritis [7].
• Kidney biopsy: A kidney biopsy is often recommended to confirm that a child has glomerulonephritis, especially if laboratory tests reveal the presence of red blood cell casts [6].

Additional diagnostic tests:

• Measurement of urine and plasma sodium and creatinine levels, as well as fractional excretion of sodium (FENa), to assess salt avidity [9].
• Streptozyme testing may also be performed.

It's worth noting that a diagnosis of autoimmune glomerulonephritis is typically made based on a combination of clinical findings, laboratory tests, and kidney biopsy results. A healthcare professional will consider the results of these diagnostic tests in conjunction with other factors to determine the best course of action for treatment.

References: [1] - [9] are citations from the provided context.

Treatment Options for Autoimmune Glomerulonephritis

Autoimmune glomerulonephritis, a condition where the immune system attacks the kidneys' filtering units (glomeruli), can be challenging to treat. However, various drug treatments are available to

Autoimmune Glomerulonephritis Differential Diagnosis

Autoimmune glomerulonephritis (GN) is a type of kidney disease characterized by the immune system attacking the glomeruli, leading to inflammation and damage. The differential diagnosis for autoimmune GN involves considering various conditions that can present with similar symptoms.

Key Conditions to Consider:

• Systemic Lupus Erythematosus (SLE): SLE is a chronic autoimmune disorder that can affect multiple organs, including the kidneys. It is often associated with antinuclear antibodies (ANA) and can cause glomerulonephritis.
• Wegener Granulomatosis: This is a rare autoimmune disorder characterized by inflammation of the blood vessels, which can lead to kidney damage.
• IgA Nephropathy: Also known as Berger's disease, this condition involves IgA antibodies depositing in the kidneys and causing inflammation.
• Membranoproliferative Glomerulonephritis (MPGN): MPGN is a type of glomerulonephritis characterized by changes in the kidney's blood vessels.

Other Conditions to Consider:

• **Rapidly Progressive Glomerul