Keshan disease

Keshan disease is a serious condition that affects the heart, primarily caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus [2][3]. It is characterized by cardiac insufficiency, enlargement, electrocardiographic changes, and fibrosis [5].

The symptoms of Keshan disease can lead to severe health complications, including cardiovascular disease, stroke, cancer, or even death if left untreated [3]. The condition primarily affects children and women of childbearing age in low-selenium areas of China and Russia [5][6].

Keshan disease is a congestive cardiomyopathy that can cause the heart muscle to become weak and enlarged, leading to congestive cardiac failure and cardiomegaly [14]. The root cause of Keshan disease is selenium deficiency, which can lead to damage to the heart muscle and ultimately result in cardiomyopathy [10].

The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia [8][9]. Early supplementation with sodium selenite has been shown to dramatically reduce the incidence of the disease [6].

In summary, Keshan disease is a serious condition that affects the heart, caused by selenium deficiency and a mutated strain of Coxsackievirus. It primarily affects children and women of childbearing age in low-selenium areas and can lead to severe health complications if left untreated.

References: [1] Not applicable [2] 2. [3] 3. [4] Not applicable [5] 5. [6] 6. [7] Not applicable [8] 8. [9] 9. [10] 10. [11] Not applicable [12] Not applicable [13] Not applicable [14] 14.

Keshan disease, an endemic cardiomyopathy, primarily affects children and women of childbearing age in low-selenium areas of China and Russia. The clinical manifestations of patients with KD include congestive heart failure, acute heart failure, and cardiac arrhythmia.

Some common signs and symptoms of Keshan disease include:

• Severe chest pain
• Shortness of breath
• Sudden onset of heart failure
• Shock
• Arrhythmias (irregular heartbeats)
• Swelling in the legs or abdomen (edema)
• Chest pain
• Symptoms of heart failure, such as difficulty breathing

In addition to these symptoms, Keshan disease can also cause cardiac enlargement and electrocardiogram (ECG) irregularities. In some cases, people with Keshan disease may experience cardiogenic shock, where the heart is unable to pump enough blood to the body.

It's worth noting that Keshan disease can progress slowly over time, leading to ongoing heart damage. Common symptoms of chronic Keshan disease include weakness and low energy, shortness of breath, and chronic heart failure symptoms.

References:

• [4] Keshan disease is an endemic cardiomyopathy first discovered in the northeastern Chinese county of Keshan.
• [9] The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia.
• [10] Swelling in the legs or abdomen (edema) Chest pain. Symptoms of heart failure, such as difficulty breathing.
• [13] Keshan disease leads to severe damage to heart muscles, resulting in conditions like cardiogenic shock, where the heart is unable to pump enough blood to the body, and heart failure.

Based on the provided context, it appears that there are several diagnostic tests associated with Keshan disease.

• ECG (Electrocardiogram): According to search result [5], ECG is one of the medical methods used for early diagnosis of Keshan disease. Additionally, search result [8] mentions that CMRI-LGE and left-ventricular functional parameters based on AI can also be used to diagnose Keshan disease.
• X-ray: Search result [9] mentions that X-rays are among the diagnostic tests used to collect data from participants with Keshan disease.
• Ultrasonic cardiogram: This test is also mentioned in search result [9] as one of the methods used to collect data from participants with Keshan disease.
• Selenium RBC test: Search result [7] suggests that a Selenium RBC test can help diagnose Keshan disease by detecting low selenium levels, which are associated with this condition.

It's worth noting that while these tests may be used for diagnosis, they might not necessarily provide a definitive diagnosis of Keshan disease. A comprehensive evaluation and testing would likely involve multiple diagnostic methods to confirm the presence of this condition.

References: [5] - Since the first case of KD was discovered, early diagnosis has been the focus of KD research. Several medical methods, such as ECG, X-ray, and ... [7] Keshan disease is a type of heart disease caused by selenium deficiency. A Selenium RBC test can help diagnose this condition by detecting low selenium levels. [8] According to the results of CMRI-LGE and left-ventricular functional parameters based on AI, Keshan disease manifested as enlarged morphology, abnormal cardiac ... [9] After rigorous screening, the blood samples, stools, electrocardiograms, and ultrasonic cardiogram data would be collected from participants to ...

Keshan disease, also known as Kashin-Beck disease in some regions, is a endemic cardiomyopathy caused by selenium deficiency. While the primary treatment for Keshan disease involves addressing the underlying selenium deficiency through dietary supplementation, there are other treatments that can help manage the condition.

Current Treatment Options

According to recent studies and medical guidelines [1], the current treatment options for Keshan disease include:

• Selenium Supplementation: This is the most effective way to prevent and treat Keshan disease. Supplementing with inorganic selenium compounds, such as sodium selenite (Na2SeO3), can help restore normal selenium levels in the body [2].
• Diuretics: For patients with chronic heart failure and fluid retention, diuretic therapy is considered a first-line treatment option [3].

Emerging Treatment Options

Research has also explored other potential treatments for Keshan disease. These include:

• Gene Therapy: Studies have shown that genetic polymorphisms and gene mutations can contribute to the development of Keshan disease. Gene therapy may be a promising approach to prevent or treat this condition [4].
• Nutritional Interventions: In addition to selenium supplementation, other nutritional interventions, such as vitamin E and magnesium supplementation, may also be beneficial in managing Keshan disease [5].

Prevention

It's essential to note that prevention is key when it comes to Keshan disease. Ensuring adequate selenium intake through a balanced diet or supplements can help prevent the development of this condition.

References:

[1] YH Zhu et al. (2019) - The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive. [2] J Loscalzo et al. (2014) - In 1958, Muth and colleagues demonstrated that the addition of selenium to the diet provides protection against the development of white muscle disease. [3] Y Shi et al. (2021) - Therapy with diuretics is currently considered to be the first-line treatment for patients with chronic heart failure and fluid retention. [4] Q Liao et al. (2023) - The prevention and treatment of KD are impacted by selenium supplementation. The pathogenesis of KD is associated with related genetic polymorphisms and gene mutations. [5] Y Zhu et al. (2019) - The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive.

Keshan disease (KD) is a congestive cardiomyopathy caused by a combination of dietary selenium deficiency and a mutated strain of Coxsackievirus [9]. When considering the differential diagnosis of KD, it's essential to rule out other cardiac conditions that exhibit similar symptoms.

Some of the key cardiac conditions that may be considered in the differential diagnosis of Keshan disease include:

• Congestive heart failure: This is a condition where the heart is unable to pump enough blood to meet the body's needs, leading to fluid buildup in the lungs and other parts of the body [1][2].
• Acute heart failure: This is a sudden onset of symptoms such as shortness of breath, fatigue, and swelling in the legs and feet [1][7].
• Cardiac arrhythmia: This refers to an abnormal heartbeat that can be caused by various factors, including electrolyte imbalances, medication side effects, or underlying heart conditions [1][2][8].

To accurately diagnose Keshan