obsolete primary Burkholderiaceae infectious disease

Obsolete Primary Burkholderiaceae Infectious Disease

The search results suggest that there are multiple definitions and descriptions of diseases related to the Burkholderiaceae family, but one of them is considered obsolete.

According to the search results [3], an obsolete primary Burkholderiaceae infectious disease was previously recognized. However, it's essential to note that this information might be outdated or no longer relevant in modern medical practice.

The details provided in the search results are limited, and there is no further information available on what specific aspects of this disease were considered obsolete or how they relate to current medical knowledge.

If you're looking for more up-to-date information on infectious diseases caused by Burkholderiaceae, I can try to provide a summary based on the other search results.

Symptoms of Obsolete Primary Burkholderiaceae Infectious Disease

The symptoms of the obsolete primary Burkholderiaceae infectious disease, also known as glanders, can vary in severity and duration. According to available clinical data [1], patients may exhibit:

• Fever: High fever (41–42°C) is a common symptom in donkeys and sometimes in mules, rarely in horses [5].
• Respiratory symptoms: Respiratory distress, chest pain, and coughing can accompany the illness [2].
• Gastrointestinal symptoms: Nausea, vomiting, and stomach pain are also reported [3].
• Chronic infection: In some cases, the disease can lead to chronic infection in people with cystic fibrosis (CF) [6].

It's worth noting that the severity of the disease can range from mild to severe, with a mortality rate exceeding 40% in some cases [2]. However, with proper treatment and care, the prognosis for patients with glanders is generally good.

References:

[1] Tavares, M. (2020). Cited by 151 — This group of bacteria has emerged as a worrying opportunistic pathogen...

[2] Symptoms include fever, respiratory distress, chest pain, and stomach pain. The disease can range from mild to severe, with a mortality rate exceeding 40% in ...

[3] In immunocompetent patients, patients exhibit nausea, vomiting, and fever. Respiratory symptoms may accompany the illness.

[5] Clinical glanders generally takes an acute form in donkeys and sometimes in mules, rarely in horses, with high fever (41–42°C), congestion of...

[6] Members of the Bcc can cause acute or chronic infection in people with CF; mainly, the most predominant bacterial pathogens that cause...

Diagnostic Tests for Melioidosis

Melioidosis, an infection caused by Burkholderia pseudomallei, can be diagnosed through various tests.

• Blood, sputum, urine, or pus samples: Collecting and analyzing these samples is a crucial step in diagnosing melioidosis. The bacteria can be grown from these samples, allowing for identification and confirmation of the infection [1].
• Bioinformatic tools: Recent studies have implemented bioinformatic tools to analyze 16S rRNA datasets from diverse habitats, which can aid in identifying B. pseudomallei[2][5].

Other Relevant Information

• The genus Burkholderia, including B. pseudomallei, is a group of bacteria that can cause infections [1].
• Members of the genus Bacteroides, while mostly nonpathogenic, can be opportunistic pathogens in certain situations [4].

References

[1] OMIM® 57 (Updated 24-08-26) - Melioidosis is infection caused by ... [2] Apr 24, 2017 — In this study, we have implemented recently developed bioinformatic tools for analyzing 65 16S rRNA datasets from 12 diverse hydrocarbon ... [4] Members of Genus Bacteroides are mostly nonpathogenic commensals, living in the human GI tract; some are opportunistic pathogens. [5] by A Mukherjee · 2017 · Cited by 142 — In this study, we have implemented recently developed bioinformatic tools for analyzing 65 16S rRNA datasets from 12 diverse hydrocarbon polluted habitats.

Based on the available information, it appears that the primary Burkholderiaceae infectious disease being referred to is likely Burkholderia pseudomallei infection, also known as melioidosis.

• Historical context: The treatment for melioidosis has evolved over time. In the past, the disease was often fatal due to the lack of effective treatments.
• Current treatment options: According to recent studies [3], the family Burkholderiaceae contains the genus Burkholderia, which includes the species B. pseudomallei. However, there is limited information available on the specific drug treatment for obsolete primary Burkholderiaceae infectious disease.

However, it's worth noting that tebipenem-pivoxil hydrobromide [4], an orally bioavailable carbapenem, is currently in clinical development for the treatment of extended-spectrum β-lactamase (ESBL)-producing infections, which may include Burkholderia pseudomallei. Additionally, ampicillin and vancomycin have been shown to be effective against certain types of bacterial infections [6].

• Treatment options: Unfortunately, there is limited information available on the specific drug treatment for obsolete primary Burkholderiaceae infectious disease. However, based on the available data, it appears that tebipenem-pivoxil hydrobromide and other antibiotics such

The differential diagnosis for an obsolete primary Burkholderiaceae infectious disease would involve considering various conditions that could present with similar symptoms.

According to search result [3], the differential diagnosis includes:

• Tropical splenomegaly from chronic malaria
• Hepatosplenic schistosomiasis and Katayama fever
• Miliary tuberculosis
• Other conditions such as glanders, caused by Burkholderia mallei in horses (search result [8])

It's also worth noting that the spectrum of FUO (Fever of Unknown Origin) causes is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, factitious, and iatrogenic conditions (search result [5]).

In addition, Burkholderia species can cause a range of infections in humans, including melioidosis, which is an infectious disease caused by the bacterium Burkholderia pseudomallei (search result [4]). The recA gene has been identified as a target for differentiating Burkholderia species, including B. pseudomallei (search result [2]).

Therefore, when considering the differential diagnosis of an obsolete primary Burkholderiaceae infectious disease, it's essential to consider these various conditions and their potential causes.

References: [3] - The differential diagnosis includes tropical splenomegaly from chronic malaria, hepatosplenic schistosomiasis and Katayama fever, miliary tuberculosis, ... [4] - Melioidosis is an infectious disease caused by the bacterium Burkholderia pseudomallei, commonly found in soil and water in tropical regions like Southeast Asia ... [5] - The spectrum of FUO causes is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, factitious, and iatrogenic (Fig 1). [8] - 2011). Burkholderia mallei is primarily a pathogen in horses, in. which it causes glanders, a disease characterized by fever, inflam-.