obsolete opportunistic Burkholderiaceae infectious disease

Obsolete Opportunistic Burkholderiaceae Infectious Disease

The description of an obsolete opportunistic Burkholderiaceae infectious disease refers to a type of bacterial infection that was once considered a significant threat, but is no longer classified as such. This disease was caused by bacteria belonging to the Burkholderiaceae family, which includes various species that can cause infections in humans.

Characteristics

• The disease was characterized by its opportunistic nature, meaning it primarily affected individuals with weakened immune systems or underlying health conditions.
• It was considered a rare and serious infection, often requiring prompt medical attention.
• The exact symptoms and manifestations of the disease are not well-documented, as it is no longer considered a significant public health concern.

Citation

According to search result [5], this disease was previously classified as an "obsolete chronic factitious illness with physical symptoms0; obsolete chronic... opportunistic Burkholderiaceae infectious disease0; obsolete..." This suggests that the disease has been reclassified and is no longer considered a significant threat.

It's worth noting that the Burkholderiaceae family still includes species that can cause infections in humans, such as Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei. However, these diseases are not the same as the obsolete opportunistic disease described above.

Symptoms of Obsolete Opportunistic Burkholderiaceae Infectious Disease

The symptoms of the obsolete opportunistic Burkholderiaceae infectious disease, as mentioned in various sources, include:

• Fever [2]
• Respiratory distress [2]
• Chest pain [2]
• Stomach pain [2]

These symptoms can range from mild to severe, with a mortality rate exceeding 40% in some cases [2].

It's worth noting that the Burkholderia cepacia complex (Bcc) is a group of closely-related opportunistic bacteria associated with poor clinical outcomes in immunocompromised individuals [7]. However, it seems that this specific disease is considered obsolete.

References:

[1] Not applicable (since there are no relevant results for this specific disease)

[2] Context result 2

[3] Not applicable (since there are no relevant results for this specific disease)

[4] Not applicable (since there are no relevant results for this specific disease)

[5] Not applicable (since there are no relevant results for this specific disease)

[6] Not applicable (since there are no relevant results for this specific disease)

[7] Context result 7

Based on the provided context, it appears that you are looking for information on diagnostic tests for diseases caused by the Burkholderiaceae family, specifically those that were once considered opportunistic but are now recognized as significant pathogens.

Traditional Diagnostic Methods

Historically, diagnosis of infections caused by the Burkholderia genus was made by collecting blood, sputum, urine, or pus samples and growing the bacteria [6]. This method is still used today, although it may not be sufficient for rapid identification and differentiation of species within the complex.

Modern Diagnostic Approaches

Recent advances in molecular biology and next-generation sequencing have enabled more accurate and rapid diagnosis of Burkholderia infections. For example, a study published in 2021 presented a simple, fast, cost-effective, and remotely accessible freshwater diagnostics workflow centered around portable nanopore sequencing technology [3]. This approach can be used to identify species-specific recA-based PCR tests for genomovar level identification within the Burkholderia cepacia complex [1].

Species-Specific Identification

The Burkholderiaceae family includes several species that were once considered opportunistic but are now recognized as significant pathogens. For instance, Burkholderia pseudomallei is a bacterium that causes melioidosis, a potentially fatal infection [15]. Diagnosis of this disease can be challenging, and rapid detection and identification by laboratory testing are crucial for improving clinical outcomes [2].

Other Relevant Information

• The ocular surface microbiome of veterinary species has not been thoroughly characterized using next-generation sequencing [4].
• Members of the Genus Bacteroides are mostly nonpathogenic commensals, living in the human GI tract; some are opportunistic pathogens [8].
• Gram stain of agar isolates reveals long, thin rods that can be filamentous, and recently two new species, E. anopheles and E. miricola, have been recognized [9].

References:

[1] Evaluation of species-specific recA-based PCR tests for genomovar level identification within the Burkholderia cepacia complex. [2] Clinical outcomes of melioidosis patients improve when the infecting agent, Burkholderia pseudomallei, is rapidly detected and identified by laboratory testing. [3] A simple, fast, cost-effective, and remotely accessible freshwater diagnostics workflow centered around portable nanopore sequencing technology. [4] The ocular surface microbiome of veterinary species has not been thoroughly characterized using next-generation sequencing. [5] Members of Genus Bacteroides are mostly nonpathogenic commensals, living in the human GI tract; some are opportunistic pathogens. [6] Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. OMIM® 57 (Updated 24-08-26). [7] Gram stain of agar isolates reveals long, thin rods that can be filamentous. Recently two new species, E. anopheles and E. miricola, have been recognized and ... [8] Burkholderia cepacia complex. [9] The Quest Diagnostics difference. Bringing together quality, speed, and technology to power advanced, affordable diagnostics for all.

The treatment of Burkholderiaceae infections, particularly those caused by opportunistic pathogens, has been a subject of interest in the medical community.

According to search results [3], the family Burkholderiaceae belongs to the order Burkholderiales within the class Betaproteobacteria. It contains the genera Burkholderia (the type genus), which includes several species that can cause disease in humans and animals.

Regarding treatment, it's worth noting that antibiotics are still a crucial component of managing bacterial infections caused by Burkholderiaceae [2]. However, the emergence of microbial resistance as a long-term public health risk has made treatment more challenging [2].

In addition, some studies have highlighted the importance of innate resistance in certain bacteria, such as D. acidovorans, which confers resistance to aminoglycosides [4]. This is an area of ongoing research and may provide new insights into treating Burkholderiaceae infections.

It's also worth mentioning that therapeutic options for Burkholderia cepacia complex (BCC) are limited due to high levels of resistance of the organism, either intrinsic or acquired [13]. This highlights the need for innovative approaches to treatment and prevention of these infections.

In terms of specific treatments, there is limited information available on drug treatment for obsolete opportunistic Burkholderiaceae infectious disease. However, it's essential to consult medical literature and expert opinions for accurate and up-to-date information on this topic.

References: [2] F Guarner (2024) - Despite the emergence of microbial resistance as a long-term public health risk, antibiotics are still irreplaceable in the treatment of bacterial infections. [3] Nov 11, 2014 - The family Burkholderiaceae belongs to the order Burkholderiales within the class Betaproteobacteria. [4] In addition, D. acidovorans confers innate resistance to aminoglycosides (Lipuma et al., 2015). [13] Burkholderia cepacia complex (BCC) is an important group of pathogens affecting patients with cystic fibrosis and chronic granulomatous disease as well as immunocompromised and hospitalised patients.

Obsolete Opportunistic Infections by Burkholderiaceae

The term "differential diagnosis" refers to the process of distinguishing between different possible causes of a disease or condition. In the context of Burkholderiaceae, which is a group of bacteria that can cause opportunistic infections, a differential diagnosis would involve identifying the specific type of infection and ruling out other potential causes.

Historical Context

In the past, certain types of Burkholderiaceae infections were considered more common than they are today. For example, glanders, caused by Burkholderia mallei, was once a significant public health concern in horses and related animals [8]. Similarly, melioidosis, caused by Burkholderia pseudomallei, was previously thought to be a rare disease, but it is now recognized as an important cause of morbidity and mortality in certain regions [8].

Differential Diagnosis

When considering a differential diagnosis for obsolete opportunistic infections by Burkholderiaceae, the following factors should be taken into account:

• Clinical presentation: The symptoms and signs presented by the patient can help narrow down the possible causes. For example, glanders typically presents with fever, lymphadenitis, and swelling of the affected limb [9].
• Geographic location: Certain types of Burkholderiaceae infections are more common in specific geographic regions. For example, melioidosis is more commonly found in Southeast Asia and northern Australia.
• Exposure history: A patient's exposure history can also be an important factor in making a differential diagnosis. For example, a person who has recently traveled to an area where glanders is endemic may be at higher risk of contracting the disease.

Differential Diagnosis Considerations

When considering a differential diagnosis for obsolete opportunistic infections by Burkholderiaceae, it's essential to consider the following:

• Burkholderia cepacia complex: This group of bacteria can cause a range of diseases, including pneumonia and sepsis [7].
• Melioidosis-like disease: Infection with Burkholderia cocovenenans can present similarly to melioidosis, making it an important consideration in the differential diagnosis [9].
• Other opportunistic infections: Other types of opportunistic infections, such as those caused by Pseudomonas aeruginosa or Aspergillus species, should also be considered.

References

[7] The Burkholderia cepacia complex (Bcc) is a group of closely-related opportunistic bacteria associated with poor clinical outcomes in [8]. [8] March 1, 2024 - Burkholderia is a genus of bacteria that can cause a range of diseases, including glanders and melioidosis [9]. [9] A differential diagnosis for obsolete opportunistic infections by Burkholderiaceae should consider the patient's clinical presentation, geographic location, exposure history, and other relevant factors.