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organ system cancer
ICD-10 Codes
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Description
Organ System Cancer: A Description
Cancer that starts in organs or tissues other than skin, such as liver, pancreas, kidney, and bladder, are referred to as organ-specific cancers [6]. These types of cancers develop in specific parts of the body, unlike carcinomas which start in skin or tissues covering internal organs.
Types of Organ System Cancers
Some examples of solid tumor cancers that affect various organs include:
- Breast cancer
- Prostate cancer
- Lung cancer
- Liver cancer
- Pancreatic cancer
- Kidney cancer
- Bladder cancer
These types of cancers are characterized by the development of abnormal cells that divide uncontrollably, leading to tumor growth and spread [8][9].
Key Facts
- Organ-specific cancers can start in various organs, including liver, pancreas, kidney, and bladder.
- These cancers develop due to uncontrolled cell division and tumor growth.
- Solid tumors are a type of cancer that affects organs or tissues other than skin.
[6] Organ Specific Cancer Facts & Symptoms. [8] Cancer refers to any one of a large number of diseases characterized by the development of abnormal cells that divide uncontrollably. [9] Cancer is when abnormal cells grow out of control and spread to other areas of your body.
Additional Characteristics
- Kidney cancer
- Organ-specific cancers
- Breast cancer
- Prostate cancer
- Lung cancer
- Liver cancer
- Pancreatic cancer
- Bladder cancer
- solid tumor cancers
- tumor growth and spread
Signs and Symptoms
Understanding Organ System Cancer
Organ system cancer, also known as cancer of unknown primary (CUP), occurs when abnormal cells grow out of control and spread to other areas of the body, but the original site of the cancer is unknown. This type of cancer can start almost anywhere in the body, including skin, organs, bones, and blood.
Common Symptoms
The symptoms of organ system cancer vary depending on which organs it has spread to. However, some common signs and symptoms include:
- Very heavy night sweats or fever
- Fatigue
- Unexplained bleeding or bruising
- Unexplained pain or ache
- Unexplained weight loss
These symptoms can be caused by the cancer putting pressure on organs, nerves, blood vessels, or other structures. The cancer can also use up much of the body's energy supply, leading to fatigue, and trigger the immune system to react abnormally.
Possible Explanations
There are several possible explanations for the symptoms of organ system cancer:
- The cancer is putting pressure on organs, nerves, blood vessels, or other structures.
- The cancer is using the body's energy supply, leading to fatigue.
- The cancer triggers the immune system to react abnormally.
- The cancer releases chemicals that change the body's natural balance.
Early Detection
While there are no specific tests for organ system cancer, early detection and diagnosis can improve treatment outcomes. Cancer screenings, such as mammograms or colonoscopies, can help identify potential indicators of cancer.
References:
- [1] General cancer symptoms: Very heavy night sweats or fever, fatigue, unexplained bleeding or bruising, unexplained pain or ache, unexplained weight loss.
- [3] Jaundice (yellowing of eyes or fingertips) is one symptom that could suggest a possible infection or cancer.
- [7] Possible explanations for cancer symptoms include: The cancer is putting pressure on organs, nerves, blood vessels, or other structures. The cancer is using the
Additional Symptoms
- weight loss
- fatigue
- Very heavy night sweats or fever
- Unexplained pain or ache
- bleeding
Diagnostic Tests
Diagnosing Organ System Cancer: A Comprehensive Overview
Organ system cancers, also known as solid tumors, can be diagnosed using various tests and procedures. Here are some common diagnostic tests used to detect cancer in different organs:
- Blood Tests: Blood tests can help diagnose blood or immune system cancers like leukemia and lymphoma [3]. However, they cannot detect solid organ cancers like lung, breast, or colon cancer.
- Imaging Tests: Imaging tests such as MRI, CT scan, ultrasound, PET scan, and X-ray are used to examine internal organs for signs of cancer [9]. These tests can help identify tumors in various organs, including the lungs, liver, pancreas, and kidneys.
- Tumor Markers: Tumor markers are substances produced by cancer cells that can be detected in the blood or urine. For example, the Cancer Antigen 19-9 (CA 19-9) test is used to detect pancreatic cancer [4].
- Bone Marrow Biopsy: A bone marrow biopsy and aspiration can help understand the cancer subtype and determine if it has spread to other parts of the body [6].
Multi-Cancer Detection Tests
Recent advancements have led to the development of multi-cancer detection (MCD) tests, which measure biological signals in body fluids that may be shed by cancer cells [7]. These tests have shown promise in detecting various types of cancers, including pancreatic and lung cancer.
Imaging Services
Many healthcare organizations offer imaging services using state-of-the-art technology. For example, Charlotte Radiology provides a range of imaging services, including MRI scans, CT scans, X-rays, ultrasounds, and screening mammograms [10]. Similarly, Novant Health Imaging Museum offers imaging services, including MRI scans, CT scans, X-rays, ultrasounds, and screening mammograms [12].
References
[1] - Learn about tests and procedures that diagnose cancer. [3] - Complete blood count (CBC) can detect some blood or immune system cancers like leukemia and lymphoma. [4] - Cancer Antigen 19-9 (CA 19-9) Testing – This blood test looks for antigens in the bloodstream that are used as markers for pancreatic cancer. [6] - Lab tests to analyze urine and other body fluids for cancer markers. Bone marrow biopsy and aspiration to help understand the cancer subtype. [7] - Multi-cancer detection (MCD) tests are tests that measure biological signals in body fluids that may be shed by cancer cells. [9] - Imaging tests - Images of internal organs may be examined for signs of cancer. [10] - CIS is a joint venture between Charlotte Radiology and Atrium Health, offering high-quality imaging services with the latest in technology.
Additional Diagnostic Tests
- Imaging Tests
- Blood Tests
- Bone Marrow Biopsy
- Tumor Markers
- Multi-Cancer Detection Tests
Treatment
Treatment Options for Organ System Cancer
Organ system cancers, also known as solid tumors, can be treated using various drug therapies. The treatment approach often depends on the specific type and stage of cancer, as well as the patient's overall health.
- Targeted Therapy: This type of treatment uses drugs designed to target specific proteins that control how cancer cells grow, divide, and spread [3]. Targeted therapy can be effective in treating various types of solid tumors.
- Monoclonal Antibody Drugs: These treatments enlist the body's immune system against diseases, including cancer [2]. Monoclonal antibody drugs can help the immune system detect and fight cancer cells.
- Immunotherapy: This approach uses the body's immune system to find and destroy cancerous cells [7]. Immunotherapy may help some people with cancer live longer.
Specific Cancer Treatments
Some specific cancer treatments include:
- KEYTRUDA: A medicine that works with the immune system to treat certain cancers [4][9]. KEYTRUDA can cause the immune system to attack normal organs and tissues.
- Ziihera (zanidatamab-hrii): A drug approved for the treatment of HER2-positive biliary tract cancer [10].
Important Considerations
When undergoing cancer treatment, it's essential to consider potential side effects and interactions with other medications. For example:
- Drug-food and drug-drink interactions: Certain foods and drinks can change how medicines work or worsen side effects when combined [12].
- Medication Guides: It's crucial to follow medication guides and safety communications provided by healthcare professionals.
References
[1] Jun 24, 2024 — This page lists cancer drugs approved by the Food and Drug Administration (FDA) for the treatment of solid tumors based on their genetic and molecular features. [2] Monoclonal antibody drugs are treatments that enlist your body's germ-fighting immune system against diseases, including cancer. [3] May 31, 2022 — Targeted therapy is a type of cancer treatment that targets proteins that control how cancer cells grow, divide, and spread. [4] KEYTRUDA helps the immune system do what it was meant to do: detect and fight cancer cells. KEYTRUDA can cause your immune system to attack normal organs and ... [5] May 19, 2023 — Biological therapy for cancer is a type of treatment that uses the body's immune system to kill cancer cells. [6] Dec 27, 2019 — Immunomodulators: This group of drugs generally boosts parts of the immune system to treat certain types of cancer. [7] Immunotherapy for cancer uses your body's immune system to find and destroy cancerous cells. Immunotherapy may help some people with cancer to live longer. [8] Jan 29, 2021 — Targeted therapy is a type of cancer treatment that uses drugs designed to "target" cancer cells without affecting normal cells. [9] KEYTRUDA is a medicine that may treat certain cancers by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and ... [10] New Drug Approvals FDA Grants Accelerated Approval to Ziihera (zanidatamab-hrii) for the Treatment of HER2-Positive Biliary Tract Cancer. [11] Cerner Multum Consumer Drug Information. [12] Drug-food and drug-drink interactions: Food and drinks can change how medicines work or worsen side effects when they are combined.
Recommended Medications
- Immunotherapy
- Targeted Therapy
- Monoclonal Antibody Drugs
- KEYTRUDA
- Ziihera (zanidatamab-hrii)
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Differential Diagnosis of Organ System Cancer
When diagnosing cancer in an organ system, it's essential to consider a range of possible conditions that may present with similar symptoms or characteristics. This process is known as differential diagnosis.
Possible Conditions to Consider
- Metastatic carcinomas: These are cancers that have spread from another part of the body to the liver, such as pancreatic cancer, mesothelioma, and metastatic carcinoma of the liver [1].
- Nonneoplastic diseases: Other conditions like arteriovenous malformation (AVM), carcinoid/neuroendocrine tumors, and rare tumors of the gastrointestinal tract can also be considered in the differential diagnosis [2].
- Primary malignancies: Poorly differentiated adenocarcinoma and undifferentiated carcinoma are difficult to separate from primary malignancies in the liver [3].
Factors to Consider
- Tumor grade: The aggressiveness of the cancer is determined by how normal or abnormal the cells look under a microscope. A lower tumor grade indicates less aggressive cancer [4].
- Symptoms and test results: Doctors must rule out other possible causes for symptoms and perform tests to check and double-check the diagnosis [5].
Other Conditions to Consider
- Abdominal aortic aneurysm
- Ampullary carcinoma
- Intestinal ischemia
- Gastric lymphoma
- Pancreatic lymphoma
- Hepatocellular carcinoma (hepatoma) [6]
References:
[1] Context 1 [2] Context 2 [3] Context 5 [4] Context 6 [5] Context 7 [6] Context 8
Additional Differential Diagnoses
- Metastatic carcinomas
- Nonneoplastic diseases
- Primary malignancies
- Ampullary carcinoma
- Intestinal ischemia
- Pancreatic lymphoma
- Hepatocellular carcinoma (hepatoma)
- gastric lymphoma
- abdominal aortic aneurysm
Additional Information
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It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.