obsolete eye adnexa disease

Based on the provided context, it appears that there are several definitions related to diseases or conditions affecting the eye and its adnexa (the surrounding structures). However, one definition stands out as being specifically related to an "obsolete" condition:

• A sensory system disease that is located in the eye or the adnexa of the eye. ID. http://purl.obolibrary.org/obo/DOID_1492. Obsolete.

This suggests that there was a previously recognized condition affecting the eye and its surrounding structures, but it has since been deemed obsolete. Unfortunately, without further information, it is difficult to provide more context or details about this specific condition.

However, I can try to summarize some general information related to diseases of the eye and adnexa:

• Diseases of the eye and adnexa can be caused by a variety of factors, including inflammation, infection, trauma, and congenital conditions.
• The adnexa includes structures such as the lacrimal apparatus, extraocular

Based on the provided context, it appears that there are several signs and symptoms associated with diseases affecting the ocular adnexa.

Common Signs and Symptoms

• Chronic noninflammatory lid swelling [2]
• Proptosis (bulging of the eye) [2]
• History of allergic disease [2]
• Elevated serum levels [2]
• Pain, which can be severe and associated with nausea and vomiting due to sudden rise in Intraocular Pressure (IOP), sudden drop in vision, discharge, and other symptoms [4]

Other Possible Symptoms

• Blurred or decreased vision [6]
• Photopsia (flashing lights) [6]
• Scotomata (blind spots) [6]
• Diplopia (double vision) [6, 7]
• Palpable or visible mass, exophthalmos (bulging of the eye), ptosis (drooping eyelid), swelling or fullness, nasolacrimal duct obstruction, tearing, or discomfort [7]

Rare Systemic Symptoms

• Systemic symptoms are rare and may include pain, nausea, vomiting, and other general symptoms [4]

It's essential to note that these signs and symptoms can vary depending on the specific disease affecting the ocular adnexa. A proper diagnosis by a medical professional is necessary for accurate identification and treatment.

References: [2] - Ocular adnexal inflammation includes a wide spectrum of diseases, including idiopathic sclerosing inflammation and sclerosing dacryoadenitis [8] [4] - The pain is severe and can be associated with nausea and vomiting (due to sudden rise in IOP), sudden drop in vision, discharge and other symptoms [4] [6] - These symptoms, which tend to worsen with increasing disease severity, include blurred or decreased vision, photopsia, scotomata, dip

Based on the provided context, it appears that there are several diagnostic tests associated with diseases of the eye and adnexa.

• Corneal topography (keratography) may be included as a diagnostic test in a DTS evaluation, particularly if a patient reports distortion of vision. [1]
• Slit-lamp biomicroscopic examination of ocular adnexa, conjunctiva, and cornea is used to assess ocular surface disease. [13]
• Tear film stability (e.g., TBUT) and Schirmer test are also used in the assessment of ocular surface disease. [13]

Additionally, serologic testing provides insight or confirmation of a diagnosis of systemic diseases that may affect the eye and adnexa. [9] This can be particularly useful in conjunction with the patient's medical history and clinical findings.

It is worth noting that orbital IgG4-related disease, which can occur in adults of any age, is characterized by IgG4-positive lymphoplasmacytic infiltrations in ocular adnexal tissues. [3]

In terms of obsolete eye adnexa diseases, it appears that there are several conditions that have been studied and documented in the past. For example, orbital lymphoplasmacytic infiltrative lesions, including sclerosing inflammation, have been evaluated in a prospective study involving 24 patients. [5] Similarly, hospital admission data from the Hospital Episode Statistics database has been used to investigate trends of hospital admissions concerning diseases of the eye and adnexa in the United Kingdom over the past 20 years. [4]

Overall, it seems that there are several diagnostic tests and approaches that have been used to evaluate diseases of the eye and adnexa, including corneal topography, slit-lamp biomicroscopy, serologic testing, and analysis of hospital admission data.

References: [1] MS Milner (2017) - Cited by 279 [3] T Kubota (2012) - Cited by 92 [5] T Kubota (2010) - Cited by 140 [9] T Raviv - [13] by LM Nijm · Cited by 1 — The diagnosis of HSV is often made clinically, however, laboratory tests are available to confirm the diagnosis in more ambiguous and difficult ...

Treatment Options for Obsolete Eye Adnexa Disease

The treatment options for obsolete eye adnexa disease, also known as IgG4-related ophthalmic disease, have evolved over the years. While there is no cure for this condition, various treatments can help manage its symptoms and slow down its progression.

• Corticosteroids: These are often the first line of treatment for IgG4-related ophthalmic disease. Corticosteroid therapy has been shown to be effective in reducing inflammation and improving symptoms [8]. However, long-term use of corticosteroids can have side effects, such as cataract formation and glaucoma.
• Immunosuppressive agents: In some cases, immunosuppressive agents like cyclosporine may be used to treat IgG4-related ophthalmic disease. These medications can help reduce inflammation and prevent further damage to the eye adnexa [2].
• Targeted therapy: Targeted therapy, which involves using specific medications to target certain genetic mutations or pathways involved in the development of cancer, has also been explored as a potential treatment option for IgG4-related ophthalmic disease [4].

Important Considerations

It's essential to note that each patient's response to treatment may vary, and what works for one person may not work for another. Additionally, treatment should be tailored to the individual's specific needs and medical history.

References:

• [8] T Kubota · 2010 · Cited by 140 — Although ocular adnexal lesions in the IgG4-positive group responded favorably to corticosteroid therapy, it is difficult to evaluate the treatment outcomes ...
• [2] by MS Milner · 2017 · Cited by 279 — Anti-inflammatory and immunomodulatory agent options include cyclosporine, lifitegrast, steroids, and nutritional supplements, such as omega-3 fatty acids. In ...
• [4] by M Sen · 2024 — Targeted therapy include drugs that target specific genetic mutations, pathways or proteins involved in the development of cancer.

The differential diagnosis for diseases affecting the ocular adnexa, which includes the eyelids, conjunctival sac, lacrimal drainage system, lacrimal gland, and orbital contents, can be quite complex. Here are some key points to consider:

• Idiopathic orbital inflammation: This condition must be differentiated from orbital IgG4-related disease and ocular adnexal marginal zone B-cell lymphoma to ensure proper diagnosis and treatment.
• Conjunctival or corneal foreign bodies: These can cause eye pain and should be ruled out in the differential diagnosis, especially in young children (SI Murthy, 2020).
• Allergic eye disease: This is another condition that can cause eye symptoms and must be considered in the differential diagnosis.
• Cutaneous and ocular adnexal mass lesions: These can include abscesses, neoplasias, infectious or non-infectious granulomas, and should be ruled out through proper examination and testing (BK Collins, 1992).
• Ocular pain: This symptom can have various causes, including conjunctival lymphoma, which is the second most common ocular adnexal tumor (Sep 1, 2012).

When considering differential diagnoses for diseases affecting the ocular adnexa, it's essential to take a thorough medical history and perform a comprehensive physical examination. This may include:

• Imaging studies: Such as MRI or CT scans to rule out conditions like orbital cellulitis or pseudotumor.
• Biopsy: To confirm the presence of certain conditions, such as lymphoma.

In some cases, teleconsultation may be useful for diagnosis and treatment planning (SI Murthy, 2020).

It's worth noting that the ocular adnexa is a complex region with many potential causes of disease. A thorough understanding of the differential diagnoses and proper diagnostic workup are essential for accurate diagnosis and effective treatment.

References:

• SI Murthy (2020) [2]
• BK Collins (1992) [4]
• Sep 1, 2012 [3]