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uterine benign neoplasm

ICD-10 Codes

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Description

Characteristics of Uterine Benign Neoplasms

Uterine benign neoplasms, also known as fibroids or leiomyomas, are growths that arise from the uterine corpus or cervix. They are characterized by the absence of atypical or malignant cytological and architectural features [1]. These growths are typically not cancerous (benign) and do not become cancerous [5].

Key Features

  • Uterine fibroids are common growths that often appear during a woman's childbearing years [3].
  • They are muscular tumors that grow in the wall of the uterus (womb) [6].
  • Fibroids are almost always benign (not cancerous) and their growth is dependent on estrogen and progesterone [7].

Appearance

  • Uterine fibroids most often appear on ultrasonograms as concentric, solid, hypoechoic masses [8].
  • On cut section, they show a white, whorled appearance that is typical of leiomyomas [9].

In summary, uterine benign neoplasms are common growths that arise from the uterus and are characterized by their benign nature. They can appear in various forms and sizes, but are typically not cancerous.

References

[1] Context 1 [5] Context 5 [6] Context 6 [7] Context 7 [8] Context 8 [9] Context 9

Additional Characteristics

  • Uterine fibroids
  • muscular tumors
  • concentric, solid, hypoechoic masses
  • white, whorled appearance

Signs and Symptoms

Based on the provided context, here are the common signs and symptoms of uterine benign neoplasms, specifically fibroids:

  • Heavy menstrual bleeding [2]
  • Abnormal vaginal bleeding [3]
  • Urinating more often or experiencing urinary frequency and urgency [2][8]
  • Constipation [3]
  • Pain, pressure, or cramps in the lower abdomen [3]
  • Problems during pregnancy, including heavy bleeding and preterm labor [3]
  • Bleeding between periods [4][5]
  • Heavy bleeding during menstruation with blood clots [4]
  • Abdominal discomfort and/or fullness [5]
  • Pelvic pain [5]
  • Lower back pain [5]

It's worth noting that not all fibroids cause symptoms, and some women may experience no issues at all. However, when symptoms do occur, they can be quite bothersome.

References: [2] - Symptoms · abnormal vaginal bleeding · urinating more often · constipation · pain, pressure or cramps in the lower abdomen · problems during pregnancy, including ... [3] - Symptoms · abnormal vaginal bleeding · urinating more often · constipation · pain, pressure or cramps in the lower abdomen · problems during pregnancy, including ... [4] - Symptoms · Bleeding between periods · Heavy bleeding during your period, sometimes with blood clots · Periods that may last longer than normal · Needing to urinate ... [5] - Fibroids Symptoms · Heavy or prolonged periods · Bleeding between periods · Abdominal discomfort and/or fullness · Pelvic pain · Lower back pain · Bladder symptoms, ...

Additional Symptoms

Diagnostic Tests

Diagnostic Tests for Uterine Benign Neoplasms

Uterine benign neoplasms, also known as fibroids or leiomyomas, are non-cancerous growths that develop in the uterus. Diagnosing these growths can be done through various tests and procedures.

  • Ultrasound: This test uses sound waves to create images of the uterus and detect fibroids. It can confirm the presence of fibroids and measure their size [1].
  • Endometrial Biopsy: While primarily used for diagnosing endometrial cancer, this biopsy can also be used to rule out other conditions in premenopausal women [2].
  • MRI: Magnetic Resonance Imaging can help differentiate between a leiomyoma and a uterine sarcoma, although no pathognomonic features exist [3].
  • Hysteroscopy: This procedure involves inserting a scope into the uterus to visually examine the interior. It may be used in conjunction with other tests to diagnose fibroids or other conditions [5].

Imaging Tests

In addition to these procedures, imaging tests such as:

  • Pelvic Ultrasound: Can help detect and measure fibroids
  • MRI: Can provide detailed images of the uterus and surrounding tissues
  • CT Scans: May be used in some cases to rule out other conditions

are also used to diagnose uterine benign neoplasms.

Genomic Testing

Advanced genomic testing is available for diagnosing uterine cancer, which may involve examining a tumor for DNA alterations [8].

It's essential to consult with a healthcare provider to determine the best course of action and diagnostic tests for individual cases.

References: [1] - Ultrasound test uses sound waves to get a picture of your uterus. [2] - An endometrial biopsy is the most commonly used test for endometrial cancer. [3] - No pathognomonic ultrasound, magnetic resonance imaging or computed tomography features are able to differentiate between a leiomyoma and a uterine sarcoma. [5] - Tests used to diagnose or rule out uterine fibroids include: pelvic exam; transvaginal or pelvic ultrasound; MRI; biopsy of the lining of the uterus (called the endometrium). [8] - Advanced genomic testing is the most common lab test for uterine cancer.

Additional Diagnostic Tests

  • Ultrasound
  • MRI
  • Endometrial Biopsy
  • CT Scans
  • Genomic Testing
  • Pelvic Ultrasound
  • Hysteroscopy

Treatment

Medication Options for Uterine Fibroids

Uterine fibroids can be treated with various medications, which aim to alleviate symptoms such as heavy menstrual bleeding and pelvic pressure. Here are some medication options:

  • Hormone therapy: Medicines that target hormones controlling the menstrual cycle can help treat uterine fibroids. These medications can shrink the tumor and reduce symptoms like heavy bleeding and pelvic pressure [1].
  • Progestogens: In some cases, progestogens may be effective in treating uterine fibroids, but their use has been associated with histopathological changes that may be detrimental to the patient's health [3].

Other Treatment Options

While medication can help manage symptoms, other treatment options are also available:

  • Surgery: Surgical procedures like myomectomy (removing only the fibroids) and hysterectomy (removing the uterus) can be effective in treating uterine fibroids. Myomectomy is suitable for women who want to preserve their fertility [8].
  • Radiofrequency ablation (RFA): This minimally invasive procedure uses microwave energy to treat uterine fibroids, offering a safe and effective treatment option [2].

Additional Considerations

When considering medication or other treatments for uterine fibroids, it's essential to discuss the following with your healthcare provider:

  • Symptom management: Medications can help alleviate symptoms like heavy bleeding and pelvic pressure.
  • Tumor size and location: The size and location of the fibroid(s) will influence the choice of treatment.
  • Fertility preservation: Women who want to preserve their fertility may opt for myomectomy or other minimally invasive procedures.

References:

[1] Context result 1: Medicines for uterine fibroids target hormones that control the menstrual cycle. They treat symptoms such as heavy menstrual bleeding and pelvic pressure.

[2] Context result 2: Radiofrequency ablation (RFA): This is a safe and effective treatment that uses microwave (RF) energy to treat uterine fibroids.

[3] Context result 3: Treating uterine fibroids with progestogens may be effective in some cases, but such treatment has been associated with histopathological changes that may be detrimental to the patient's health.

[8] Context result 8: Myomectomy is a surgical procedure removing only the fibroids. It is suitable for treating fibroids in women who want to preserve the uterus for fertility.

Recommended Medications

  • Hormone therapy
  • Progestogens

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

The differential diagnosis of uterine benign neoplasms involves identifying and ruling out other possible conditions that may present with similar symptoms or characteristics.

According to the available information, the most common benign neoplastic uterine tumors are uterine fibroids or leiomyomas [2]. These growths develop monoclonally from the smooth muscle cells of the uterus and can vary in size, number, and location. Uterine fibroids are a type of benign tumor that is often difficult to distinguish from malignant uterine leiomyosarcomas using imaging techniques alone [8].

Other conditions that may be considered in the differential diagnosis of uterine benign neoplasms include:

  • Benign uterine leiomyomas (fibroids)
  • Uterine smooth muscle tumors of uncertain malignant potential
  • Rare cases of uterine lipoleiomyoma

It's worth noting that the differential diagnosis with uterine sarcoma may be difficult, and a small percentage of resected tumors diagnosed preoperatively as leiomyomas are actually found to be malignant [6].

In order to establish an accurate diagnosis, it is essential to consider all possible conditions and to use a combination of clinical evaluation, imaging studies, and histopathological examination.

References:

[2] S Ghildiyal (2024) - The most common benign neoplastic uterine tumors that grow monoclonally from the smooth muscle cells of the uterus are uterine fibroids or leiomyomas. [6] C Abdel Wahab (2020) - The differential diagnosis with uterine sarcoma may be difficult, and 0.01%–0.5% of resected tumors diagnosed preoperatively as leiomyomas are actually found to be malignant. [8] S Sun (2019) - Uterine leiomyomas, the most frequent benign myomatous tumors of the uterus, often cannot be distinguished from malignant uterine leiomyosarcomas using imaging techniques alone.

Additional Differential Diagnoses

  • Benign uterine leiomyomas (fibroids)
  • Uterine smooth muscle tumors of uncertain malignant potential
  • Rare cases of uterine lipoleiomyoma

Additional Information

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