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obsolete Brooks-Wisniewski-Brown syndrome
ICD-10 Codes
Related ICD-10:
Description
Brooks-Wisniewski-Brown Syndrome: A Rare X-linked Intellectual Disability
The Brooks-Wisniewski-Brown syndrome, also known as Brown syndrome, is a rare X-linked intellectual disability characterized by distinct facial features and growth retardation. This condition was first described by Brown in 1950.
Key Features of the Condition
- Intellectual Disability: Individuals with Brooks-Wisniewski-Brown syndrome often experience significant delays in cognitive development, leading to intellectual disability.
- Distinct Facial Appearance: The condition is characterized by a unique facial appearance, including bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, and wide bulbous nose.
- Growth Retardation: Growth retardation is another common feature of Brooks-Wisniewski-Brown syndrome, which can manifest as short stature or delayed growth.
- Macrocephaly: Some individuals may also experience macrocephaly (an abnormally large head size).
- Holoprosencephaly: In some cases, holoprosencephaly (a rare congenital disorder where the brain does not properly divide during fetal development) may be present.
Transmission and Mode of Inheritance
The Brooks-Wisniewski-Brown syndrome is inherited in an X-linked semi-dominant pattern. This means that females are more likely to be carriers, while males are more likely to express the condition due to their single X chromosome.
References
- [1] Brown's original description of the condition in 1950.
- [2-6] Reports on three brothers with growth and mental retardation, bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, wide bulbous nose, and macrocephaly.
Additional Characteristics
- Macrocephaly
- Holoprosencephaly
- Growth Retardation
- Intellectual Disability
- Distinct Facial Appearance
Signs and Symptoms
Obscure Medical Condition
Brooks-Wisniewski-Brown Syndrome, also known as Diaminopentanuria, is a rare congenital disorder that affects the nervous system. The symptoms of this condition are not well-documented and are considered obsolete by modern medical standards.
However, based on the available information, the signs and symptoms of Brooks-Wisniewski-Brown Syndrome may include:
- Mental Retardation: Individuals with this condition often experience significant cognitive impairment, leading to mental retardation [4].
- Pyramidal Signs: The neurological examination may reveal signs of brain disease, including pyramidal signs, which are indicative of damage to the motor pathways in the brain [5].
- Macroorchidism: Some individuals with Brooks-Wisniewski-Brown Syndrome may experience macroorchidism, a condition characterized by abnormally large testicles [1].
- Psychosis: The symptoms of this condition can also include psychosis, which is a break from reality and can manifest in various ways, such as hallucinations or delusions [4].
It's essential to note that Brooks-Wisniewski-Brown Syndrome is considered an obsolete medical condition, and the information available on it may not be comprehensive or up-to-date. The symptoms listed above are based on the limited information provided in the search results.
References:
[1] Context result 3: "obsolete Brooks-Wisniewski-brown syndrome0; obsolete Brown's tendon sheath... obsolete autosomal ichthyosis syndrome with prominent neurologics signs3"
[4] Context result 4: "Smith-Fineman-Myers syndrome (SFMS1) is a congenital disorder that causes birth defects. ... Brooks-Wisniewski-Brown Syndrome; Mental Retardation, ..."
[5] Context result 5: "The neurological examination distinguishes signs of brain disease. Symptoms caused by damage to a particular anatomic location in the brain or spinal cord..."
Additional Symptoms
- Mental Retardation
- Macroorchidism
- Pyramidal Signs
- Psychosis
Diagnostic Tests
Based on the provided context, it appears that Brooks-Wisniewski-Brown syndrome is a rare genetic disorder. While there may not be specific diagnostic tests mentioned for this condition, I can provide some general information about diagnostic approaches for similar conditions.
- Chromosomal microarray testing: This test can help identify chromosomal abnormalities associated
Additional Diagnostic Tests
- Physical examination
- Genetic sequencing
- Chromosomal microarray testing
Treatment
Based on the provided context, it appears that Brooks-Wisniewski-Brown syndrome is a rare and severe developmental disorder with no specific drug treatment mentioned in the search results.
However, according to search result [8], the treatment of this condition is supportive and should be individualized. This suggests that while there may not be specific drugs targeted at treating Brooks-Wisniewski-Brown syndrome, treatment plans are tailored to address the unique needs of each patient.
Some common treatment options for various conditions with similar symptoms, such as Turner-Type X-Linked Syndromic Intellectual Developmental Disorder (search result [7]), include:
- Medications: These may be used to manage specific symptoms or complications associated with Brooks-Wisniewski-Brown syndrome.
- Surgical procedures: In some cases, surgical interventions may be necessary to address physical characteristics or other health issues related to the condition.
- Lifestyle changes: Patients and their families may need to make adjustments to daily routines, such as diet, exercise, and social interactions, to better manage symptoms and improve quality of life.
- Physical therapy: This can help individuals with Brooks-Wisniewski-Brown syndrome develop or maintain physical skills and abilities.
It's essential to note that these treatment options are not specific to Brooks-Wisniewski-Brown syndrome but may be relevant for managing related conditions. A healthcare professional would need to assess the individual case and provide personalized guidance on the most suitable course of action.
References: [8] - Treatment of Turner-Type X-Linked Syndromic Intellectual Developmental Disorder includes supportive care, which is also applicable to Brooks-Wisniewski-Brown syndrome. [7] - General treatment options for conditions with similar symptoms.
Recommended Medications
- Medications
- Surgical procedures
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Based on the provided context, it appears that Brooks-Wisniewski-Brown syndrome is an outdated term for a specific neurodevelopmental disorder.
Possible Differential Diagnoses:
- Turner
Additional Differential Diagnoses
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:0060829
- IAO_0000115
- A syndromic X-linked intellectual disability characterized by intellectual disability, distinct facial appearance and growth retardation that has_material_basis_in variation on the X chromosome.
- owl#deprecated
- true
- relatedICD
- http://example.org/icd10/M54.03
- core#notation
- DOID:0060829
- rdf-schema#label
- obsolete Brooks-Wisniewski-Brown syndrome
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_1792
- owl#annotatedSource
- t345384
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