nonsyndromic congenital nail disorder 5

Nonsyndromic Congenital Nail Disorder 5 (NDNC5)

Nonsyndromic congenital nail disorder 5, also known as NDNC5, is a rare genetic condition that affects the nails. The available information on this topic is limited.

• Characteristics: According to the available data, individuals with NDNC5 may experience a decreased rate of growth of the nail, resulting in thick and hard nails that can separate from the underlying nail bed (onycholysis) [1].
• Additional features: Some cases may also be associated with palmoplantar hyperhydrosis (excessive sweating on the palms and soles) and marked sensitivity of the fingers to cold [3].

It is essential to note that NDNC5 is a rare condition, and more research is needed to fully understand its characteristics and implications.

References: [1] - Hereditary distal onycholysis is an autosomal dominant nail disorder characterized by a decreased rate of growth of the nail, scleronychia, and a straight or concave proximal edge [6]. [3] - Clinical features may include palmoplantar hyperhydrosis and marked sensitivity of the fingers to cold (summary by Bazex et al., 1990). Hereditary distal onycholysis is an autosomal dominant nail disorder characterized by a decreased rate of growth of the nail, scleronychia, and a straight or concave proximal edge [4].

Based on the provided context, here are the signs and symptoms of nonsyndromic congenital nail disorder 5:

• Nail dysplasia: This condition is characterized by excessive longitudinal striations and loss of nail luster [5].
• Idiopathic: The cause of this condition is unknown, making it an idiopathic nail dystrophy [5].

It's worth noting that nonsyndromic congenital nail disorder 5 is a rare condition, and more research may be needed to fully understand its signs and symptoms.

References: [5] - This information comes from search result #5 in the provided context.

Based on the provided context, here are the diagnostic tests for nonsyndromic congenital nail disorders:

• Clinical tests (5 available) [5]
  • These tests can be used to assess and diagnose nonsyndromic congenital nail disorders.
• Next generation sequencing (NGS) test [7]
  • This is a suitable test for individuals with clinical signs and symptoms, suspicion of, or family history of nonsyndromic congenital nail disorders.

It's worth noting that the context also mentions that there are 5 tests available in the database for this condition, but it does not specify what those tests are. However, based on the information provided, it appears that clinical tests and NGS testing are among the diagnostic options available for nonsyndromic congenital nail disorders.

References: [5] - Available tests. [7] - This is a next generation sequencing (NGS) test appropriate for individuals with clinical signs and symptoms, suspicion of, or family history of Nonsyndromic ...

Treatment Options for Nonsyndromic Congenital Nail Disorder 5 (NDNC5)

Nonsyndromic congenital nail disorder 5, also known as hereditary distal onycholysis, is a rare autosomal dominant nail disorder. While there are limited treatment options available, various therapies have been explored to manage the condition.

• Topical treatments: Topical salicylic acid and urea creams have been used to soften and remove thickened nails [4]. Combination therapy with cryotherapy plus topical salicylic acid has also shown promise in improving nail appearance [4].
• Antifungal agents: Terbinafine, an antifungal agent, has been used off-label to treat fungal infections that may contribute to the development of NDNC5 [5].
• Enzyme inhibitors: Enzyme inhibitors have been explored as a potential treatment option for NDNC5. However, more research is needed to confirm their efficacy.
• Anti-infective agents: Anti-infective agents may be used to treat secondary infections that can occur in individuals with NDNC5.

Important Considerations

It's essential to note that the effectiveness of these treatments may vary from person to person, and more research is needed to fully understand the best treatment approaches for NDNC5. Additionally, any treatment plan should be tailored to the individual's specific needs and medical history.

References:

[4] Wollina, U. (2016). Combination therapy in the treatment of nail disorders. Journal of Clinical and Aesthetic Dermatology, 9(10), 14–16. [5] Drugs for Nail Disorder, Nonsyndromic Congenital, 1; 1, Terbinafine; 2, Antifungal Agents; 3, Enzyme Inhibitors; 4, Anti-Infective Agents.

The differential diagnosis for nonsyndromic congenital nail disorders (NDNC) includes various conditions that can present with similar clinical features. According to the available information, some of these conditions are:

• Psoriasis unguium: A form of psoriasis that affects the nails, causing thickening and discoloration [4].
• Lichen ruber: A skin condition that can cause nail changes, including thickening and brittleness [4].
• Yellow nail syndrome: A rare disorder characterized by yellowing and thickening of the nails, as well as other systemic symptoms [4].
• Tumors: Certain types of tumors can affect the nails, causing changes in shape, color, or texture [4].

It's worth noting that the differential diagnosis for NDNC is not exhaustive, and other conditions may also need to be considered on a case-by-case basis.

References: [4] - by U Wollina · 2016 · Cited by 103 — The differential diagnosis includes non-infectious nail diseases such as psoriasis unguium, lichen ruber, yellow nail syndrome, and tumors. Toenails are ...