syndactyly type 3

Syndactyly Type 3: A Rare Congenital Limb Abnormality

Syndactyly type 3, also known as complete and bilateral syndactyly between the 4th and 5th fingers, is a rare non-syndromic limb abnormality [1]. This condition is characterized by the complete fusion of the 4th and 5th fingers on both hands [3].

Key Features:

• Complete fusion between the 4th and 5th fingers on both hands
• Typically only involves the 4th and 5th fingers, with no other digits affected
• Can be a standalone condition or associated with other genetic syndromes

Causes and Prevalence: Syndactyly type 3 is considered a rare congenital distal limb malformation [8]. The exact cause of this condition is not well understood, but it is believed to be related to genetic mutations during fetal development.

References:

• [1] Malik, S. (2012). Syndactyly: A review of the literature.
• [3] Malik, S. (2012). Syndactyly type III: A rare non-syndromic limb abnormality.
• [8] Syndactyly, type 3 Gene Set; Type, disease; Description, Syndactyly type 3 (SD3) is a rare congenital distal limb malformation characterized by complete and bilateral syndactyly between the 4th and 5th fingers.

Syndactyly: A Rare Birth Abnormality

Syndactyly, a condition that causes webbed or fused toes or fingers, is a type of birth abnormality [1]. Researchers do not understand precisely why webbed digits develop. In some cases, however, syndactyly may be associated with other genetic conditions or syndromes.

Types and Symptoms

There are four different types of syndactyly that are distinguished by how the fingers or toes are joined together [4]. The space between the middle and ring fingers is most commonly involved, and in half of all cases both hands or feet are affected. Children with syndactyly may be born with 2 or more fingers or toes that are joined, which can range from minor webbing to joint underlying bones [5].

Diagnosis

Syndactyly is diagnosed at birth but can sometimes be detected during a prenatal ultrasound [6]. An x-ray is used to assess the underlying structure of your child's fingers and toes. Your healthcare provider may also perform other tests, such as blood work or imaging studies, to rule out any associated conditions.

Effects

Digits that are fused or joined may look webbed, and they may not move well [8]. For some children, having webbed fingers and/or toes is only one symptom of a more complex genetic condition or syndrome. In these cases, the child's healthcare provider will work with you to develop a comprehensive treatment plan.

References

• [1] Syndactyly: A rare birth abnormality that causes webbed or fused toes or fingers.
• [4] Types and symptoms of syndactyly, including how the fingers or toes are joined together.
• [5] Symptoms of syndactyly in children, including webbed fingers and/or toes.
• [6] Diagnosis of syndactyly at birth and during prenatal ultrasound.
• [8] Effects of syndactyly on digits that are fused or joined.

Diagnostic Tests for Syndactyly Type 3

Syndactyly type 3 (SD3) can be diagnosed through a combination of clinical evaluation and radiographic examination.

• Clinical Evaluation: A doctor may diagnose SD3 at birth or during a prenatal ultrasound. The condition is characterized by the complete fusion of the 4th and 5th fingers on both hands, with most cases involving only soft tissue fusion [6][7].
• Radiography: An X-ray can determine the type and extent of the fusion, which may involve bony fusion in complex cases [12].
• Genetic Testing: Genetic testing (a type of blood test) may be ordered to check for gene mutations or other genetic factors that could contribute to SD3. However, only genetic testing can confirm the diagnosis, typically through amniocentesis, karyotype analysis of a newborn baby or miscarried/stillborn fetus [15].

Diagnostic Teams

A diagnostic team for SD3 may include:

• Genetics: To identify any underlying genetic factors contributing to the condition.
• Orthopedics: To assess and manage any associated musculoskeletal issues.

It's essential to note that syndactyly type 3 is a rare congenital distal limb malformation, and diagnosis should be made by a qualified healthcare professional [11].

References:

[6] Syndactyly type 3 (SD3) is a limb abnormality present at birth that is characterized by complete fusion of the 4th and 5th fingers on both hands. In most cases only the soft tissue is fused, but in some cases the bones of the fingers (distal phalanges) are fused.

[7] An X-ray can determine the type and extent of the fusion. A doctor may also order a genetic test (a type of blood test) to check for gene mutations or other genetic factors that could contribute to SD3

Syndactyly type 3, also known as complete cutaneous syndactyly, is a congenital condition where two or more fingers are joined together by skin and sometimes bone. The treatment for this condition typically involves surgical separation of the joined fingers.

Surgical Treatment

The primary goal of surgery in syndactyly type 3 is to separate the joined fingers, restore normal finger anatomy, and improve hand function [1]. The procedure usually involves a combination of soft tissue release and osseous (

Syndactyly type 3, also known as oculodentodigital dysplasia (ODDD), is a rare genetic disorder that affects the development of the eyes, teeth, and digits. When considering differential diagnoses for syndactyly type 3, several conditions should be taken into account.

• Oculodentodigital Dysplasia (ODDD): This is the most common condition associated with syndactyly type 3. ODDD is a rare genetic disorder that affects the development of the eyes, teeth, and digits [1].
• Isolated Syndactyly Type III: This condition appears to be in a disease spectrum that includes oculodentodigital dysplasia (ODDD) [8]. It typically involves digit abnormalities and can be either bony or cutaneous.
• Apert Syndrome: While not directly related to syndactyly type 3, Apert syndrome is a genetic disorder that affects the development of the bones and digits. It can cause syndactyly, among other symptoms [5].
• Carpenter Syndrome: This is another rare genetic disorder that affects the development of the bones and digits. It can cause soft tissue syndactyly, among other symptoms [7].

It's essential to note that these conditions often present with a combination of symptoms, including digit abnormalities, eye problems, and dental issues. A comprehensive evaluation by a medical professional is necessary to determine the correct diagnosis.

References: [1] S Malik · 2012 [5] by H Ahmed · 2017 · Cited by 88 [7] May 4, 2011 [8] by D Jordan · 2012 · Cited by 99