larynx leiomyoma

Laryngeal Leiomyoma: A Rare Benign Tumor

A laryngeal leiomyoma is a rare type of benign tumor that arises from the smooth muscle cells in the larynx, which is the voice box. This tumor is characterized by the presence of spindle cells with cigar-shaped nuclei and interlacing fascicles.

Key Characteristics:

• Benign nature: Laryngeal leiomyomas are non-cancerous tumors.
• Smooth muscle origin: They arise from smooth muscle cells in the larynx.
• Rare occurrence: This tumor is extremely rare, with only 14 cases described in the literature so far.
• Slow growth: Laryngeal leiomyomas are slow-growing and seldom recur following complete excision.

Symptoms and Diagnosis:

The symptoms of a laryngeal leiomyoma may include difficulty swallowing or breathing. A diagnosis is typically made through a combination of physical examination, imaging studies (such as CT or MRI scans), and biopsy.

Treatment Options:

Treatment for laryngeal leiomyomas usually involves surgical excision, which can be performed endoscopically or through an open approach. In some cases, radiation therapy may also be considered.

References:

• [1] A benign smooth muscle neoplasm arising from the larynx. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles... (Search Result 3)
• [2] This neoplasm is extremely rare in the larynx as only 14 cases have been described in the literature so far. Only 4 of these could be defined as subglottic. The ... (Search Result 4)
• [3] It is a slow growing benign tumor that seldom recurs following complete excision. Rich in vascular components it is usually found in the skin of the limbs and... (Search Result 5)

Common Signs and Symptoms of Laryngeal Leiomyoma

Laryngeal leiomyoma, a type of non-cancerous tumor, can cause various symptoms depending on its location and size. Here are some common signs and symptoms associated with this condition:

• Hoarseness: A weak or breathy voice is often the first symptom of laryngeal leiomyoma [4].
• Dysphagia: Trouble swallowing food or liquids can also occur due to the tumor's location in the throat [2, 3].
• Foreign body sensation: Some people may experience a feeling of something being stuck in their throat [2, 3].
• Ear pain: Pain in the ear can be a symptom of laryngeal leiomyoma, although it is not always present [1].
• Dyspnea: Difficulty breathing or shortness of breath can occur if the tumor grows large enough to obstruct airflow [5].

It's essential to note that these symptoms can vary from person to person and may not be present in every case. If you're experiencing any unusual symptoms, it's crucial to consult a healthcare professional for proper evaluation and diagnosis.

References:

[1] SP Suresh (2012) - Final diagnosis of leiomyoma of larynx simple type was made. [2] Y Wu (2024) - Dysphagia and foreign body sensation in the throat were also typical symptoms. [3] Y Wu (2024) - The current case involved a supraglottic LM. [4] B Lawal (2014) - The clinical presentation depends on the part of larynx affected, including hoarseness. [5] M Veeresh (2013) - Leiomyoma is a benign tumor of rare incidence in the head and neck regions.

Laryngeal leiomyomas are rare benign tumors that can be challenging to diagnose. However, various diagnostic tests can help identify these tumors.

Imaging Tests

• CT scans and MRI scans with contrast enhancement can be used to help in diagnosis and surgical planning [6]. These imaging tests can show the location and size of the tumor.
• Imaging tests can also help rule out other conditions that may have similar symptoms, such as laryngeal cancer.

Endoscopy and Biopsy

• Endoscopy with biopsy is a crucial diagnostic test for laryngeal leiomyomas [8]. This procedure involves inserting a flexible endoscope or a rigid scope into the throat to visualize the tumor and take a tissue sample.
• The peroral technique or flexible endoscope can be used to conduct office-based laryngeal biopsies [4].

Other Diagnostic Tests

• Histopathological examination and immunohistochemical tests may also be performed to confirm the diagnosis of laryngeal leiomyoma [1].
• Direct laryngoscopy, laryngeal videoendoscopy, and videostroboscopy can also be used to visualize the tumor and take a biopsy [1].

It's worth noting that preoperative diagnosis of laryngeal leiomyomas is difficult, but imaging tests and endoscopy with biopsy can help confirm the diagnosis [9].

Differential Diagnosis of Laryngeal Leiomyoma

Laryngeal leiomyoma, a rare benign tumor, requires accurate diagnosis to differentiate it from other conditions that may present similar symptoms. The differential diagnoses for laryngeal leiomyoma include:

• Hemangioma: A vascular tumor that can cause similar symptoms and appearance as leiomyoma [5].
• Vascular Leiomyosarcoma: A malignant tumor that can be confused with leiomyoma due to its similar histological features [5].
• Fibromas and Lipomas: Connective tissue tumors that may present similar findings to leiomyoma, requiring a differential diagnosis [13].
• Spindle Cell Carcinoma, Fibrosarcoma, Myofibrosarcoma, Rhabdomyosarcoma, Malignant Melanoma, and Inflammatory Myofibroblastic Tumor: These conditions can be distinguished from leiomyoma through histological examination [4], [5].

Key Points to Consider

• Laryngeal leiomyoma is a rare condition, but it should be included in the differential diagnosis for laryngeal swellings [12].
• Accurate diagnosis requires histological and immunohistochemistry examination to confirm the presence of angioleiomyoma or vascular leiomyoma [6], [15].
• Differential diagnosis has important clinical significance, especially in cases where surgical resection is considered [1].

References

[1] Surgical resection is the preferred treatment for LLMs, its early diagnosis and differential diagnosis have important clinical significance. Keywords: Leiomyoma, Larynx, Smooth tumor, Endoscopic surgery, Case report.

[4] Differential diagnosis has to distinguish LMS from leiomyoma, spindle cell carcinoma, fibrosarcoma, myofibrosarcoma, rhabdomyosarcoma, malignant melanoma, and inflammatory myofibroblastic tumor [4], [5].

[5] Which of the following is most likely the correct diagnosis? Leiomyoma Leiomyosarcoma Malignant peripheral nerve sheath tumor PEComa Synovial sarcoma (monophasic)

[6] The diagnosis of angioleiomyoma is confirmed by histological and immunohistochemistry examination. ... Neuman T, Ilan O, Ben-Yaakov A. Recurrent vascular leiomyoma of the larynx: clinical and histopathologic ...

[12] In spite of the rarity of this disease in the larynx, it should be included in the differential diagnosis for laryngeal swellings.

[13] Clinically, connective tissue tumors e.g. fibromas, lipomas may present similar findings to leiomyoma; hence a differential diagnosis must be established. Histological findings play a key role in the final diagnosis of leiomyoma. ... 58 with skin of head and neck, 52 with oral cavity, 22 with larynx, 12 with orbit, 6 with the nasal cavity and ...

[15] angioleiomyoma, vascular myoma, larynx, carbon dioxide laser technology Introduction Angioleiomyoma or vascular leiomyoma is a benign subcu-taneous or deep dermal tumor of smooth muscle and vessels. Most vascular leiomyomas are found in the skin, but in the head and neck area, it can also developed in the mucosa,1,2