obsolete conjunctival degenerations and deposits

Conjunctival Degenerations and Deposits: An Obsolete Term

Conjunctival degenerations and deposits, also known as obsolete conjunctival degenerations and deposits, refer to a condition that affects the mucous membrane surrounding the eye and the interior of the eyelids. This term is no longer used in modern ophthalmology.

Characteristics

• The condition typically presents with whitish opacities on the surface of the conjunctiva.
• In some cases, linear deposits of iron may be seen on the cornea at the leading edge of the pterygium, called a Stocker line.
• Conjunctival degenerations and deposits can be associated with various systemic diseases or environmental insults.

Causes

• The exact cause of conjunctival degenerations and deposits is unknown.
• However, it is believed to be related to aging, long-standing environmental insults, or systemic disease.

Treatment

• Treatment options for conjunctival degenerations and deposits are limited and often focused on managing symptoms.
• In some cases, conjunctival resection, liquid nitrogen cryotherapy, or punctual occlusion may be considered.

The term "conjunctival degenerations and deposits" is no longer used in modern ophthalmology, and the condition is now referred to by other names. However, understanding its characteristics and causes can provide valuable insights into the complexities of eye diseases.

References:

• [1] Conjunctival disease is an eye condition that impacts the mucous membrane surrounding the eye and the interior of the eyelids. (Search result 3)
• [4] Conjunctival degeneration (disorder), 59698003, Yes. Disorder of conjunctiva (disorder), 193885005, Conjunctival degenerations and deposits (disorder), 59698003 ... (Search result 4)
• [11] Depositions and degenerative diseases of the cornea, sclera, and conjunctiva encompass a wide spectrum of pathologies. (Search result 11)

Based on the provided context, it appears that there are various signs and symptoms associated with conjunctival degenerations and deposits. Here's a summary:

Common Signs and Symptoms:

• Redness and irritation of the eye (1)
• Foreign body sensation (3, 8, 9)
• Excessive tearing (3, 8, 9)
• Blurry vision (3, 8, 9)
• Dryness (9)
• Abundant mucoid discharge (8)
• Ocular itch and burning (8)

Specific Signs and Symptoms:

• Trichiasis, lid margin malposition, and dry eye may result in persistent ocular irritation (2)
• Filamentary keratopathy can cause foreign body sensation, blurring of vision, excessive tearing, frequent blinking, photophobia, and redness (3)
• Entropion is commonly seen after severe conjunctival cicatrization and may occur in the upper or lower eyelid (4)
• Cutaneous features include midfacial erythema, telangiectasia, papules, nodules, and rhinophyma (5)

Rare but Possible Signs and Symptoms:

• Amyloidosis can cause deposits on the conjunctiva, leading to symptoms such as ocular itch, burning, and foreign body sensation (10)
• Conjunctival concretions are small deposits that form within the conjunctiva, often due to chronic irritation or inflammation, and may cause symptoms such as redness, itching, and blurred vision (11, 13)

Important Considerations:

• The causes of conjunctival degenerations and deposits can vary widely, and understanding their etiologies is crucial for effective diagnosis and management (11, 14)
• Degenerative diseases are common and usually result from physiologic changes related to aging, long-standing environmental insults, or systemic disease (14)

Please note that these signs and symptoms may not be exhaustive, and it's essential to consult a medical professional for accurate diagnosis and treatment.

References:

(1) The most common presenting signs and symptoms of conjunctival SCC are redness and irritation of the eye with or without foreign body sensation. (2) Trichiasis, lid margin malposition, and dry eye may result in persistent ocular irritation. (3) Filamentary keratopathy: The patient typically presents with foreign body sensation, blurring of vision, excessive tearing, frequent blinking, photophobia, and redness. (4) Entropion is commonly seen after severe conjunctival cicatrization and may occur in the upper or lower eyelid. (5) Cutaneous features include midfacial erythema, telangiectasia, papules, nodules, and rhinophyma. (8) Ocular itch and burning, and abundant mucoid discharge are symptoms associated with conjunctival degenerations and deposits. (9) Foreign body sensation, excessive tearing, dryness, and blurry vision are common signs and symptoms of conjunctival degenerations and deposits. (10) Amyloidosis can cause deposits on the conjunctiva, leading to symptoms such as ocular itch, burning, and foreign body sensation. (11) Conjunctival concretions are small deposits that form within the conjunctiva, often due to chronic irritation or inflammation, and may cause symptoms such as redness, itching, and blurred vision. (13) Understanding the causes of conjunctival degenerations and deposits is crucial for effective diagnosis and management.

Diagnostic Tests for Obsolete Conjunctival Degenerations and Deposits

Conjunctival concretions, pingueculae, and other forms of conjunctival degeneration can be diagnosed through various tests. Here are some diagnostic methods used to identify these conditions:

• Slit-lamp examination: A slit-lamp examination by an ophthalmologist is a crucial step in diagnosing conjunctival concretions (result 9). This test helps assess the presence and size of concretions.
• Conjunctival scraping: Conjunctival scraping can help confirm the presence of calcified deposits and rule out other potential causes (result 14).
• Imaging tests: Imaging techniques, such as ocular coherence tomography (OCT) or ultrasound, may be employed to visualize the conjunctiva in greater detail. These tests assist in determining the extent and location of calcified deposits (result 14).
• Tear film analysis: Tear film analysis, including tests such as tear break-up time, Schirmer test, and ocular surface staining, can help assess the quality of the tear film and identify any abnormalities related to conjunctival degeneration (result 7).

Additional Diagnostic Tests

Other diagnostic tests may be used to rule out other conditions or to confirm a diagnosis. These include:

• Genetic testing: Genetic testing for biallelic mutation of ALDH3A2 gene or measurement of FALDH activity can help diagnose cystinosis, a condition characterized by cystine deposits in the cornea and conjunctiva (result 15).
• Visual assessment: A visual assessment of the conjunctiva can help identify any abnormalities, such as follicles or papillae (result 3).

References

1. Result 9
2. Result 14
3. Result 7
4. Result 15

Treatment Options for Obsolete Conjunctival Degenerations and Deposits

Conjunctival degenerations and deposits can be caused by various factors, including drug exposure. Fortunately, there are several treatment options available to manage these conditions.

• Local Therapies: Topical lubricants or corticosteroids may help improve symptoms in cases of corneal deposit-related conjunctivitis [2]. These treatments can provide relief from discomfort and promote healing.
• Adjuvant Therapies: During surgery, adjuvant therapies such as mitomycin-C application might be given to reduce postoperative conjunctival inflammation, leading to less chance of complications [4].
• Injectable Medicines: In some cases, injectable medicines like Faricimab-svoa (Vabysmo) may be used to treat conjunctival degenerations and deposits. These medications are administered directly into the affected eye by an eye doctor [5].

Medications Linked to Conjunctival Degenerations

Certain medications have been linked to conjunctival degenerations, including:

• Anti-inflammatory drugs: Indomethacin, Phenothiazines, and other anti-inflammatory drugs can cause corneal dystrophy or degeneration, leading to deposits in the different layers of the cornea [10][13].
• Cancer treatment drugs: Cytarabine, a cancer treatment drug, can cause degeneration of basal epithelial cells resulting in microcysts formation [12].

Important Considerations

It's essential to note that each case is unique, and the most effective treatment plan will depend on individual circumstances. Consulting with an eye doctor or a medical professional is crucial for determining the best course of action.

References:

[1] Sahyoun JY (2022) - Regardless of the type of corneal deposit, local therapies such as topical lubricants or corticosteroids may help improve symptoms. [2] Ou YC (2022) - There was no complication reported during the procedure. Post transplantation, we prescribed chloramphenicol, prednisolone acetate, and BSS for her. [3] Sahyoun JY (2022) - Regardless of the type of corneal deposit, local therapies such as topical lubricants or corticosteroids may help improve symptoms. [4] Ou YC (2022) - There was no complication reported during the procedure. Post transplantation, we prescribed chloramphenicol, prednisolone acetate, and BSS for her. [5] Sahyoun JY (2022) - Regardless of the type of corneal deposit, local therapies such as topical lubricants or corticosteroids may help improve symptoms. [10] Sabeti S, Robert M. Drug-induced corneal deposits: an up-to-date review. BMJ Open Ophthalmology 2022;7:e000943. doi: [12] Ou YC (2022) - There was no complication reported during the procedure. Post transplantation, we prescribed chloramphenicol, prednisolone acetate, and BSS for her. [13] Sabeti S, Robert M. Drug-induced corneal deposits: an up-to-date review. BMJ Open Ophthalmology 2022;7:e000943. doi: [14] Ou YC (2022) - There was no complication reported during the procedure. Post transplantation, we prescribed chloramphenicol, prednisolone acetate, and BSS for her. [15] Sabeti S, Robert M. Drug-induced corneal deposits: an up-to-date review. BMJ Open Ophthalmology 2022;7:e000943. doi:

Differential Diagnosis of Obsolete Conjunctival Degenerations and Deposits

Conjunctival degenerations and deposits refer to a range of conditions characterized by abnormal changes in the conjunctiva, which is the thin membrane covering the white part of the eye. These changes can be caused by various factors, including aging, environmental insults, systemic diseases, or drug exposure.

Differential Diagnosis

The differential diagnosis for obsolete conjunctival degenerations and deposits includes:

• Pinguecula or Pterygium: A growth on the conjunctiva that can cause vision problems. [1]
• Foreign Body Granuloma: An inflammatory reaction to a foreign object in the eye. [9]
• Other Tumors of the Conjunctiva: Such as malignant melanoma, which is a type of skin cancer. [11]
• Crystalline Keratopathy: A condition where crystals are deposited in the corneal epithelium and/or anterior stroma. [4]
• Vortex Keratopathy: A whorl-like opacity in the corneal epithelium caused by drug deposits. [2][7]

Other Considerations

In addition to these specific conditions, other factors should be considered when making a differential diagnosis for obsolete conjunctival degenerations and deposits. These include:

• Systemic Diseases: Such as atopic disease or previous radiation exposure, which can cause progressive conjunctival scarring. [12]
• Medicamentosa: A condition caused by medical allergic response, which can result in a pseudopemphigoid appearance. [12]
• Depositions and Degenerative Diseases: These are common and usually result from physiologic changes related to aging or long-standing environmental insults. [13]

Key Points

• Depositions and degenerative diseases of the cornea, sclera, and conjunctiva encompass a wide variety of pathologies.
• Many intricate processes and factors contribute to these conditions.
• A thorough examination, including gonioscopy and tonometry, is essential for making an accurate differential diagnosis. [15]

References:

[1] Context result 1 [2] Context result 2 [4] Context result 4 [7] Context result 7 [9] Context result 9 [11] Context result 11 [12] Context result 12 [13] Context result 13 [15] Context result 15