obsolete leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb

Obsolete Leukemic Reticuloendotheliosis of Lymph Nodes of Axilla and Upper Limb

Leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb was a term used to describe a rare type of chronic leukemia that affects the lymph nodes in the axilla and upper limb. This condition is now considered obsolete, but it was previously recognized as an independent clinical and pathologic entity.

Characteristics

According to medical literature [3], leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb was characterized by:

• Leukemic infiltration of the lymph nodes in the axilla and upper limb
• Enlargement of the para-aortic lymph nodes up to 3 cm in size (Case 2)
• Presence of abnormal mononuclear cells suggestive of leukemia in biopsy samples

Incidence

The incidence of leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb was approximately 2% of all leukemias seen at a hospital each year [3].

ICD-9 Code

This condition was previously classified under the ICD-9 code 202.44, which is now considered obsolete.

Synonyms

Some synonyms for this condition include:

• Leukemic reticuloendotheliosis of lymph nodes of axilla
• Leukemic reticuloendotheliosis of lymph nodes of head and face
• Leukemic reticuloendotheliosis of lymph nodes of inguinal region and lower limb

References

[3] - A classic report published in 1958 described 26 patients with leukemic reticuloendotheliosis and established the concept that it is an independent clinical and pathologic entity. [13] - This source provides information on obsolete leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb, including synonyms.

Based on the search results, here are the signs and symptoms of leukemic reticuloendotheliosis affecting the lymph nodes in the axilla and upper limb:

• Swollen lymph nodes: The lymph nodes in the neck, underarm (axilla), groin, or stomach may become swollen, which can be a sign of leukemic reticuloendotheliosis [10][11][14].
• Enlarged lymph nodes in the axilla: In some cases, the lymph nodes in the axilla may become enlarged, firm, and non-tender, as seen in one of the case studies [3].
• Painless lymph nodes: The swollen lymph nodes can be painless, which is a characteristic feature of leukemic reticuloendotheliosis [14].
• Lymphadenopathy: Lymphadenopathy, or the enlargement of lymph nodes, is a common symptom of leukemic reticuloendotheliosis, affecting various regions including the axilla and upper limb [13].

It's worth noting that these symptoms can be similar to those of other conditions, and a definitive diagnosis can only be made through histopathological examination.

Based on the search results, it appears that leukemic reticuloendotheliosis is a rare type of chronic leukemia. While there are no specific diagnostic tests mentioned for this condition in the provided context, I can provide some general information on diagnostic tests that may be relevant.

• Biopsy: A biopsy of the affected lymph nodes may be performed to examine the cells and tissues under a microscope. This can help confirm the diagnosis of leukemic reticuloendotheliosis.
• Cytochemical demonstration: The cytochemical demonstration of tartrate-resistant acid phosphatase isoenzyme in the reticuloendothelial cells (as mentioned in search result 5) may be used to diagnose leukemic reticuloendotheliosis. This test can help identify the presence of abnormal cells.
• Flow cytometric analysis: Flow cytometry can be used to analyze the peripheral blood and detect small clonal B-cell populations, which may indicate an overlooked diagnosis of CLL (as mentioned in search result 9).
• Fine needle punctures: Fine needle punctures of the lymph nodes, liver, hypertrophied spleen, bone marrow, thoracic or abdominal effusions can be used for immediate cytological analyses (as mentioned in search result 10).

Please note that these diagnostic tests may not be specific to leukemic reticuloendotheliosis and may be used for other conditions as well. It's also worth mentioning that the provided context does not mention any specific diagnostic tests for this condition, but rather provides general information on related topics.

References: * [5] - Cytochemical demonstration of tartrate-resistant acid phosphatase isoenzyme in the reticuloendothelial cells. * [9] - Flow cytometric analysis to detect small clonal B-cell populations. * [10] - Fine needle punctures for immediate cytological analyses.

Based on the search results, it appears that there are limited information available on the drug treatment for leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb. However, I can provide some general information on cancer treatment.

Cancer Treatment Overview

Cancer treatment typically involves a combination of therapies, including surgery, chemotherapy, radiation therapy, and targeted therapy. The choice of treatment depends on the type and stage of cancer, as well as the patient's overall health.

• Chemotherapy: This is a systemic treatment that uses medications to kill cancer cells throughout the body. Chemotherapy can be administered orally or intravenously.
• Targeted Therapy: This type of therapy uses medications that specifically target cancer cells, reducing harm to healthy cells.
• Radiation Therapy: This treatment uses high-energy rays to kill cancer cells.

Leukemic Reticuloendotheliosis Treatment

Unfortunately, I couldn't find any specific information on the drug treatment for leukemic reticuloendotheliosis of lymph nodes of axilla and upper limb. However, based on the search results, it appears that this condition is a rare type of cancer.

• According to [1], leukemic reticuloendotheliosis is a rare neoplastic process.
• [2] mentions that cancer cells in lymph nodes have broken away from the original tumor and traveled via the lymph vessels to a lymph node.
• However, I couldn't find any information on specific drug treatments for this condition.

Current Treatment Options

Given the rarity of leukemic reticuloendotheliosis, it's likely that treatment options are limited. In general, cancer treatment involves a combination of therapies, including surgery, chemotherapy, radiation therapy, and targeted therapy.

If you're looking for more information on cancer treatment or specific treatments for leukemic reticuloendotheliosis, I recommend consulting with a medical professional or a reputable health organization.

References:

[1] MedlinePlus: Leukemia [2] Cancer.Net: Lymphoma

Differential Diagnosis of Leukemic Reticuloendotheliosis

Leukemic reticuloendotheliosis, also known as Histiocytic Medullary Reticulosis, is a rare type of chronic leukemia that affects the lymph nodes. The differential diagnosis for leukemic reticuloendotheliosis involves considering various conditions that can cause enlargement or abnormalities in the lymph nodes.

Common Causes of Axillary Lymphadenopathy

• Infections: such as cellulitis, abscesses, or lymphangitis [12]
• Trauma: including injuries to the upper extremities [12]
• Tumors: both benign and malignant, including breast cancer, lymphoma, and leukemia [11]

Other Differential Diagnoses

• Lymphadenitis: an inflammation of the lymph nodes, which can be caused by infections or other conditions [7]
• Leukemia: including acute and chronic forms, such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) [13]
• Lymphoma: a type of cancer that affects the immune system, including Hodgkin's lymphoma and non-Hodgkin's lymphoma [13]

Key Points to Consider

• The axilla contains both lymph nodes and non-lymphatic tissue, making it a complex region for differential diagnosis [11]
• A wide range of conditions can cause axillary lymphadenopathy, including infections, trauma, tumors, and other diseases [12]
• Leukemic reticuloendotheliosis is a rare type of chronic leukemia that affects the lymph nodes, and its differential diagnosis involves considering various conditions that can cause similar symptoms [13]

References

[7] - It is helpful for purposes of the differential diagnosis to consider infective lymphadenitis in several categories (see Table 97-1): (1) regional ...

[11] - a wide range of differential diagnoses because the axilla contains both lymph nodes and non-lymphatic tissue such as accessory breast tissue, skin, fat, muscles, nerves, blood vessels, and is surrounded by bone.

[12] - Lymphadenopathy refers to lymph nodes that are abnormal in size (e.g., greater than 1 cm) or consistency. ... Infections or injuries of the upper extremities are a common cause of axillary ...

[13] - IN 1958 we published a classic report 1 in which we described 26 patients with leukemic reticuloendotheliosis (LRE) and established the concept that it is an independent clinical and pathologic entity. Since then, more than 180 articles have been published concerning this rare type of chronic leukemia. Its incidence is approximately 2% of all the leukemias seen at our hospital each year.