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obsolete pupillary margin miotic cyst

Description

A pupillary margin miotic cyst, also known as an iris pigment epithelium (IPE) cyst, is a type of cyst that occurs at the pupillary margin of the iris. This condition is caused by the use of miotics, which are medications that constrict the pupil.

Characteristics:

  • A pupillary margin miotic cyst is a small, round or oval-shaped cyst that forms at the edge of the iris.
  • It is usually translucent or white in color and can be visible without dilation.
  • The cyst is caused by the accumulation of cells from the iris pigment epithelium.

Causes:

  • Prolonged use of miotics, such as phospholine iodide or phenylephrine eye drops, can lead to the formation of a pupillary margin miotic cyst.
  • Discontinuing the causative medication often leads to resolution of the cyst.

Symptoms:

  • The presence of a pupillary margin miotic cyst may not cause any symptoms initially.
  • However, if left untreated, it can potentially lead to visual problems or complications.

Treatment:

  • In some cases, discontinuation of the causative medication may be sufficient to resolve the cyst.
  • In other cases, treatment with medications such as phenylephrine 2.5% eye drops may be necessary.

References:

[1] (Context #14) - For drug-induced cysts, discontinuation of the causative medication often leads to resolution of the cyst. [2] (Context #14) - In cases of cysts secondary to miotic use, such as phospholine iodide, phenylephrine 2.5% eye drops may be used. [3] (Context #8) - The pupil can become rigid after long-term application of miotics and can be damaged genetically, by inflammation (iritis), ... [4] (Context #9) - Discontinuing miotics in miotic-induced pupillary block f).

Additional Characteristics

  • A small, round or oval-shaped cyst that forms at the edge of the iris.
  • The cyst is usually translucent or white in color and can be visible without dilation.
  • The cyst is caused by the accumulation of cells from the iris pigment epithelium.
  • Prolonged use of miotics can lead to the formation of a pupillary margin miotic cyst.
  • Discontinuing the causative medication often leads to resolution of the cyst.
  • Treatment with medications such as phenylephrine 2.5% eye drops may be necessary.

Signs and Symptoms

Symptoms of Pupillary Margin Miotic Cyst

While most patients with pupillary margin miotic cyst are asymptomatic, there are some possible signs and symptoms to be aware of:

  • Progressive enlargement of the cyst: As the cyst grows, it may cause symptoms such as [3].
  • Blurred vision: The presence of a cyst can cause blurry or distorted vision, although this is not always the case [8].

Other Possible Symptoms

In some cases, patients with pupillary margin miotic cyst may experience other symptoms, including:

  • Pupil contractions: Abnormal pupil constriction can be caused by damage to nerves in the brain or adjacent parts, which can lead to miosis (pupillary constriction) [5].
  • Unequal size of the pupils: An unequal size of the pupils can be a sign of ocular pathology, such as congenital or structural anomalies [6].

Rare Complications

In rare cases, pupillary margin miotic cysts can cause more severe complications, including:

  • Local corneal oedema: Cysts can cause local corneal swelling and irritation.
  • Erratic behavior: In some cases, cysts can cause erratic behavior in horses, such as shying, decreased performance, and head-shaking [12].

It's essential to note that these symptoms may not always be present or severe. If you suspect you have a pupillary margin miotic cyst, it's crucial to consult with an eye care professional for proper diagnosis and treatment.

References:

[3] Symptoms. [5] Pupil contractions are made possible by the iris sphincter pupillae, which are controlled by nerves in the brain. Any damage to these nerves or adjacent parts can cause abnormal pupil constriction. [6] Neurologists are frequently consulted because of a pupillary abnormality. An unequal size of the pupils can be a sign of ocular pathology, such as congenital or structural anomalies. [8] Symptoms: Blurred vision: The presence of a cyst can cause blurry or distorted vision, although this is not always the case. [12] by EKL Stas · 2023 · Cited by 2 — However, cysts can cause local corneal oedema and erratic behaviour like shying, decreased performance and head-shaking.

Additional Symptoms

  • Progressive enlargement of the cyst
  • Pupil contractions
  • Unequal size of the pupils
  • Local corneal oedema
  • Erratic behavior
  • blurred vision

Diagnostic Tests

Based on the provided context, it appears that you are looking for diagnostic tests related to an obsolete condition affecting the pupillary margin.

Possible Diagnostic Tests:

  • Slit-lamp examinations [5]
    • This test can help identify iris cysts, which may be associated with the condition.
  • Ultrasonography [4]
    • Bilateral ultrasonography was performed in 26/35 horses to confirm the diagnosis of fluid-filled iris cysts.
  • Ocular biometry [10]
    • This test measures the distance between various ocular structures, which may be relevant in assessing the condition.

Other Relevant Information:

  • Ciliary block glaucoma can be diagnosed by eliminating the possibility of pupillary block, and a patent iridectomy must be established before this diagnosis is made [7].
  • Optic nerve assessment is also an important examination, especially in follow-up patients on miotic therapy or those showing changes in IOP [9].

Important Considerations:

  • Cystic corpora nigra appear as large, smooth structures at the pupillary margin and may obstruct the pupil enough to cause visual impairment or blindness [3].
  • Diode laser treatment is a useful and safe option for iris cyst size reduction, with a low risk of recurrence [1][2].

Please note that these diagnostic tests are based on the provided context and might not be directly related to the obsolete condition you are looking for. However, they may still be relevant in assessing similar conditions affecting the pupillary margin.

References: [1] - Context 1 [2] - Context 2 [3] - Context 3 [4] - Context 4 [5] - Context 5 [7] - Context 7 [9] - Context 9 [10] - Context 10

Additional Diagnostic Tests

  • Ultrasonography
  • Slit-lamp examinations
  • Ocular biometry

Treatment

Based on the provided context, it appears that there are several treatment options for pupillary margin miotic cysts.

  • Phenylephrine 2.5%: This medication is used to treat iris cysts secondary to miotics (phospholine iodide) [13]. It can help resolve the cyst by discontinuing the use of phospholine iodide or the implicated medication.
  • Discontinuation of implicated medication: In some cases, simply stopping the use of the medication that caused the cyst can lead to its resolution [13].
  • No treatment required for stable cysts: If the cyst is stable and not causing symptoms or secondary complications, no treatment may be necessary. However, it's still important to follow up with a healthcare professional to monitor the situation [13].

It's worth noting that these treatment options are based on the provided context and may not be comprehensive or up-to-date.

References: [13] - Treatment entails use of topical antiamebic agents and, in more severe cases, surgical debridement. There are no clear guidelines for treatment of this disease; however, discontinuation of phospholine iodide or the implicated medication can lead to resolution of the cyst [13].

Differential Diagnosis

Based on the provided context, it appears that differential diagnosis for pupillary margin miotic cysts involves considering various conditions that may present similarly.

  • Iris pigment epithelium (IPE) cysts: These are a type of primary iris cyst that can be located at the pupillary margin. They are typically thin-walled and hollow, with regular borders on ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS OCT). [1]
  • Tumors: Malignant tumors, such as iris melanoma, should also be considered in the differential diagnosis of pupillary margin miotic cysts. The main indicator of malignancy is an increase in lesion size. [14, 26, 27]
  • Other conditions: Other rare neoplastic conditions and trauma should always be considered in the differential diagnosis of recurrent hyphaema in children. [7]

It's worth noting that discontinuation of the causative medication often leads to resolution of the cyst in cases where it is secondary to miotic use, such as phospholine. [3] However, in some cases, the problem of differential diagnosis can be complex and may require further evaluation.

References:

[1] Context 2 [14] Context 2 [26] Context 2 [27] Context 2 [7] Context 9

Additional Information

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