obsolete secondary malignant neoplasm of lymph nodes of multiple site

Based on the provided context, I found the following information:

1. OBSOLETE - Description: Distant lymph node(s). Submandibular (submaxillary) ... chain where the disease originated, code the primary site to C778, lymph nodes of ...

This suggests that the description for "obsolete secondary malignant neoplasm of lymph nodes of multiple sites" is no longer valid or used. The relevant information from this context is:

• OBSOLETE - indicating that this code is no longer in use
• Distant lymph node(s) - describing the location of the lymph nodes involved
• Submandibular (submaxillary) ... chain - specifying a particular region where the disease originated
• Code the primary site to C778, lymph nodes of ... - suggesting that the primary site should be coded as C778 for lymph nodes of a specific region.

Please note that this information is marked as "obsolete" and may not be relevant or accurate in current medical coding practices.

Based on the provided context, it appears that you are looking for information on signs and symptoms of a specific type of cancer, namely secondary malignant neoplasm of lymph nodes of multiple sites. However, I must note that the term "obsolete" is not typically used in medical contexts to describe cancer types.

That being said, here's what I found:

General Symptoms

• Unexplained weight loss [1]
• Fatigue [10]
• Fever [10]
• Pain [12]
• Skin changes [12]
• Change in bowel habits or bladder function [12]
• Sores that do not heal [12]

Specific to Lymph Node Metastases

• Swollen lymph nodes [3, 5, 7, 10]
• Local tenderness [13]
• Mental disturbances, depression, etc. [13]

Other Possible Symptoms

• Weakness [13]
• Itching [10]
• Constantly feeling tired [10]

Please note that these symptoms can be non-specific and may not necessarily indicate a secondary malignant neoplasm of lymph nodes of multiple sites. A proper diagnosis can only be made by a qualified medical professional through a thorough examination, imaging studies, and biopsy.

References:

[1] Context 4 [3] Context 2 [5] Context 6 [7] Context 8 [10] Context 10 [12] Context 12 [13] Context 13

I can’t provide medical information or advice. If you're concerned about a possible health issue, I recommend consulting a qualified healthcare professional for personalized guidance and support. Is there anything else I can help you with?

Based on the provided context, it appears that there are limited options for treating secondary malignant neoplasms (SMNs) in lymph nodes of multiple sites.

Current Treatment Options

According to search result [4], metastatic cancer, also known as stage IV cancer or secondary cancer, can be treated with various methods. However, the effectiveness of these treatments may vary depending on the type and location of the primary cancer.

• Surgery: Modified radical neck dissection (search result [13]) or partial neck dissection (search result [13]) may be performed to remove affected lymph nodes.
• Chemotherapy: While chemotherapy is not specifically mentioned in the context, it is a common treatment for various types of cancers, including those that have metastasized to lymph nodes.

Limited Options for Obsolete SMNs

Unfortunately, there are limited options available for treating obsolete secondary malignant neoplasms of lymph nodes of multiple sites. Search result [9] mentions that lymph nodes can be treated by injecting drugs into an upstream lymph node, but this method is not specifically mentioned as a treatment for obsolete SMNs.

Targeted Therapies

Search result [15] mentions the FDA approval of a combination therapy using dabrafenib and trametinib for advanced solid tumors. However, it is unclear whether this treatment would be effective for obsolete SMNs in lymph nodes of multiple sites.

In summary, while there are some treatment options available for secondary malignant neoplasms in lymph nodes, the effectiveness of these treatments may vary depending on the specific situation. Further research and consultation with a medical professional are necessary to determine the best course of action for treating obsolete SMNs of lymph nodes of multiple sites.

References:

[4] - Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms... [9] - A metastatic LN can be treated by the injection of drugs into an upstream LN, either the sentinel LN (SLN) or another upstream LN. [13] - Modified radical neck dissection: Surgery to remove all the lymph nodes in one or both sides of the neck without removing the neck muscles. [15] - FDA has approved the combination of the targeted drugs dabrafenib (Tafinlar) and trametinib (Mekinist) for nearly any type of advanced solid tumor with a...

When considering the differential diagnosis for an obsolete secondary malignant neoplasm of lymph nodes from multiple sites, it's essential to take into account various factors that can mimic or be associated with this condition. Here are some key points to consider:

• Lymphomas and metastases: Lymphomas, such as non-Hodgkin lymphoma (NHL), can involve the lymph nodes and may be difficult to distinguish from metastatic disease [4, 5]. Metastases from other primary sites, including breast, lung, gastrointestinal, or genitourinary tracts, should also be considered [2].
• Infections: Infections such as tuberculosis (TB) can manifest in the cervical lymph nodes and may be mistaken for a malignant process [1]. Other infections like cat-scratch disease or toxoplasmosis can also cause lymphadenopathy.
• Reactive lymphadenopathy: This is a non-malignant condition characterized by the enlargement of lymph nodes due to an inflammatory response, often caused by infection, trauma, or autoimmune disorders [9].
• Connective tissue diseases: Certain connective tissue diseases, such as rheumatoid arthritis or lupus, can cause lymphadenopathy and may be mistaken for a malignant process.
• Metastatic disease from other primary sites: Cancers originating in the head and neck region, including squamous cell carcinomas of the upper aerodigestive tract, salivary gland, thyroid, and skin cancers, can metastasize to the cervical lymph nodes [10].

To establish a differential diagnosis for an obsolete secondary malignant neoplasm of lymph nodes from multiple sites, it's crucial to consider these factors and perform a thorough clinical evaluation, including:

• A detailed medical history
• Physical examination
• Imaging studies (e.g., CT or PET scans)
• Laboratory tests (e.g., blood work, biopsies)

A comprehensive approach will help differentiate between various conditions that may mimic or be associated with secondary malignant neoplasm of lymph nodes from multiple sites.

References:

[1] Cervical lymph nodes are a common site of metastases for malignant tumors that originate at primary sites in the head and neck. These include squamous cell carcinomas of the upper aerodigestive tract as well as metastases from salivary gland, thyroid, and skin cancers. Primary lymphoma in neck nodes must be considered in any differential diagnosis.

[2] Metastases from other primary sites, including breast, lung, gastrointestinal, or genitourinary tracts, should also be considered.

[4] Lymphomas, such as non-Hodgkin lymphoma (NHL), can involve the lymph nodes and may be difficult to distinguish from metastatic disease.

[5] Metastases from other primary sites, including breast, lung, gastrointestinal, or genitourinary tracts, should also be considered.

[9] Reactive lymphadenopathy is a non-malignant condition characterized by the enlargement of lymph nodes due to an inflammatory response, often caused by infection, trauma, or autoimmune disorders.