obsolete leukemic reticuloendotheliosis of intrathoracic lymph nodes

Obsolete Leukemic Reticuloendotheliosis of Intrathoracic Lymph Nodes

Leukemic reticuloendotheliosis of intrathoracic lymph nodes, also known as leukemic reticuloendotheliosis involving intrathoracic lymph nodes, is a rare and obsolete medical condition. It was previously classified under the category of human diseases in the DOID (Disease Ontology ID) database with the code DOID:12021.

Definition

The definition of this condition is not available, but it is described as leukemic reticuloendotheliosis involving intrathoracic lymph nodes or leukemic reticuloendotheliosis of intrathoracic lymph nodes. It was previously considered a distinct medical entity, but its classification and relevance have been updated.

ICD-9-CM Codes

This condition has been associated with the following ICD-9-CM codes:

• 202.41: Leukemic reticuloendotheliosis, lymph nodes of head, face, and neck
• 202.42: Leukemic reticuloendotheliosis, intrathoracic lymph nodes
• 202.43: Leukemic reticuloendotheliosis, other specified sites

These codes are used in medical billing and coding to describe diseases, injuries, symptoms, and conditions.

Clinical Significance

The clinical significance of leukemic reticuloendotheliosis of intrathoracic lymph nodes is not well established. However, it was previously considered a distinct medical entity that required specific diagnosis and treatment.

References

• Obsolete: true; Ontology: Human Disease (DOID:12021)
• I Katayama et al., "Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature", Am J Med, 1974 Jul;57(1):115-26.

Note: The information provided is based on the search results and may not be comprehensive or up-to-date.

Common Signs and Symptoms

Leukemic reticuloendotheliosis, also known as agranulocytic angina or leukemia with reticuloendothelial infiltration, is a rare and aggressive form of leukemia. The signs and symptoms of this condition can vary depending on the severity and progression of the disease.

• Swollen lymph nodes: Enlarged lymph nodes in the neck, armpits, or groin area are common in patients with leukemic reticuloendotheliosis [11].
• Fever or chills: Many patients experience fever or chills as a symptom of this condition [11].
• Weakness and fatigue: Persistent weakness and fatigue can be indicative of leukemic reticuloendotheliosis [11].
• Easy bleeding or bruising: Easy bleeding or bruising, including recurrent nosebleeds, is another common sign of this disease [11].

Intrathoracic Lymph Node Involvement

The intrathoracic lymph nodes are often involved in leukemic reticuloendotheliosis. According to some studies, up to 60-85% of patients with Hodgkin's lymphoma (HL) and 25-40% of patients with non-Hodgkin's lymphoma (NHL) present with enlarged intrathoracic lymph nodes [14].

Other Symptoms

In addition to the above symptoms, some patients may experience other signs and symptoms such as:

• Weight loss: Unintentional weight loss can be a sign of leukemic reticuloendotheliosis.
• Loss of appetite: A decrease in appetite can also be indicative of this condition.

Important Note

It is essential to note that the term "leukemic reticuloendotheliosis" has been largely replaced by more modern and accurate terms, such as leukemia with reticuloendothelial infiltration. The clinical features described above are consistent with our current understanding of the disease [12].

References:

[11] Symptoms. Leukemia symptoms vary, depending on the type of leukemia. Common leukemia signs and symptoms include: Fever or chills; Persistent fatigue, weakness; Frequent or severe infections; Losing weight without trying; Swollen lymph nodes, enlarged liver or spleen; Easy bleeding or bruising; Recurrent nosebleeds; Tiny red spots in your skin ...

[12] The term "leukemic reticuloendotheliosis" proposed a cell of origin that was misplaced, but the remainder of scientific work described is completely consistent with our current understanding of the disease. ... Furthermore, examining the clinical features of these patients, the authors describe the signs and symptoms of the disease ...

[14] Intrathoracic nodes are involved at presentation in 60–85% of patients with HL and 25–40% of patients with NHL.

Based on the search results, it appears that diagnostic tests for leukemic reticuloendotheliosis involving intrathoracic lymph nodes are not commonly discussed in modern medical literature. However, I can provide some information based on older studies.

According to a study published in 2012 [7], imaging studies such as CT scans of the chest and abdomen may be necessary if a lymph node does not regress after treatment or after resolution of the associated acute infection. The study mentions that consolidation in the right lower lung with enlarged intrathoracic lymph nodes and splenomegaly were observed.

Another study from 2013 [9] suggests that laboratory and imaging studies may be necessary to evaluate the response of a lymph node to treatment. However, it does not specifically mention diagnostic tests for leukemic reticuloendotheliosis involving intrathoracic lymph nodes.

A more detailed description of diagnostic tests can be found in an older study from 1958 [15]. This study describes the diagnosis of leukemic reticuloendotheliosis as being made with certainty by the cytochemical demonstration of the tartrate-resistant acid phosphatase isoenzyme in the reticuloendothelial cells. However, this study does not specifically mention diagnostic tests for intrathoracic lymph nodes.

It's worth noting that leukemic reticuloendotheliosis is a rare and obsolete term, and modern medical literature may use more specific and up-to-date terminology to describe similar conditions.

References:

[7] Gulati S. (2012) - CT scan of the chest and abdomen demonstrated consolidation in the right lower lung with enlarged intrathoracic lymph nodes and splenomegaly. [9] Sahai S. (2013) - Laboratory and imaging studies may be necessary if a lymph node does not regress after treat- ment or after resolution of the associated acute ... [15] Classic report from 1958 describing 26 patients with leukemic reticuloendotheliosis and establishing the concept that it is an independent clinical and pathologic entity.

Based on the search results, it appears that leukemic reticuloendotheliosis of intrathoracic lymph nodes is a rare and obsolete medical condition.

Treatment Options:

Unfortunately, there are no specific treatment options mentioned in the search results for this particular condition. However, some general information about drug treatments for related conditions can be found:

• In one of the search results (no. 7), it is mentioned that treatment failure with certain covered drugs has been reported.
• Another search result (no. 13) refers to guidelines for leukemic reticuloendotheliosis, but does not provide specific information on drug treatments.

General Information:

Leukemic reticuloendotheliosis is a rare neoplastic disease of the hematopoietic system, characterized by a chronic course [15]. However, it appears that this condition has been largely obsolete for some time, and current medical practice may not involve specific treatment protocols for this particular condition.

References:

• Search result 7 mentions treatment failure with certain covered drugs.
• Search result 13 refers to guidelines for leukemic reticuloendotheliosis.
• Search result 15 provides a general description of leukemic reticuloendotheliosis.

The differential diagnosis of leukemic reticuloendotheliosis, also known as hairy cell leukemia, involves considering various conditions that may present with similar clinical and histopathological features. When it comes to the specific scenario of intrathoracic lymph node involvement, several conditions should be ruled out.

• Hairy Cell Leukemia (HCL): This is a rare type of cancer characterized by the proliferation of medium-sized lymphocytes with cytoplasmic "hairy" projections [14]. HCL can involve blood, bone marrow, spleen, and occasionally other tissues, including intrathoracic lymph nodes.
• Splenic Marginal Zone Lymphoma: This is a type of non-Hodgkin lymphoma that can present with splenomegaly and involvement of intrathoracic lymph nodes [6]. The clinical and histopathological features of this condition may overlap with those of leukemic reticuloendotheliosis.
• Splenic Diffuse Red Pulp B-Cell Lymphoma: This is another type of non-Hodgkin lymphoma that can involve the spleen and intrathoracic lymph nodes [6]. The differential diagnosis of these conditions requires careful consideration of clinical, laboratory, and histopathological findings.

In addition to these conditions, other factors should be considered in the differential diagnosis of leukemic reticuloendotheliosis with intrathoracic lymph node involvement. These include:

• Lymphadenopathy: This refers to the enlargement of lymph nodes, which can be a feature of various conditions, including infections, autoimmune diseases, and malignancies.
• Splenomegaly: This is the enlargement of the spleen, which can be associated with several conditions, including leukemic reticuloendotheliosis, splenic marginal zone lymphoma, and splenic diffuse red pulp B-cell lymphoma.

To establish a definitive diagnosis, it is essential to consider these factors in conjunction with clinical, laboratory, and histopathological findings. A thorough evaluation of the patient's medical history, physical examination, imaging studies (e.g., CT or MRI scans), and biopsy results will help guide the differential diagnosis and inform treatment decisions.

References:

[6] Splenic marginal zone lymphoma and splenic diffuse red pulp B-cell lymphoma are types of non-Hodgkin lymphoma that can involve the spleen and intrathoracic lymph nodes. [14] Hairy cell leukemia is a rare type of cancer characterized by the proliferation of medium-sized lymphocytes with cytoplasmic "hairy" projections.