obsolete recurrent malignant endocervical neoplasm

Recurrent Malignant Endocervical Neoplasm: An Obsolete Term

The term "recurrent malignant endocervical neoplasm" is an outdated medical description that was once used to refer to a type of cancerous growth in the endocervix, which is the inner lining of the cervix. This condition was characterized by the recurrence or persistence of malignant (cancerous) cells in the endocervix after initial treatment.

Historical Context

In the past, this term was used to describe a type of cancer that was considered to be relatively rare but had a poor prognosis. The exact incidence and prevalence of this condition are not well-documented, as it is an obsolete term that has been largely replaced by more modern and accurate descriptions of cervical cancer.

Current Understanding

Today, the concept of recurrent malignant endocervical neoplasm is no longer used in medical practice. Instead, healthcare providers use more specific and up-to-date terminology to describe similar conditions, such as:

• Recurrent cervical cancer
• Persistent cervical cancer
• Adenocarcinoma of the cervix (a type of cancer that originates from glandular cells)

These modern terms reflect a better understanding of the underlying biology and pathology of cervical cancer, as well as advances in diagnostic techniques and treatment options.

References

[8] - This term is mentioned in the context as "obsolete recurrent malignant endocervical neoplasm" without further description. [12] - Malignant and premalignant endocervical glandular lesions are relatively rare but their incidence appears to be increasing.

Common Signs and Symptoms of Recurrent Cervical Cancer

Recurrent cervical cancer, also known as recurrent endocervical neoplasm, can exhibit a range of symptoms, which may vary in severity and frequency. Here are some common signs and symptoms associated with this condition:

• Pelvic pain: Pain or discomfort in the pelvic area is a common symptom of advanced cervical cancer [4].
• Back pain: Back pain can also occur due to the spread of cancer cells to the spine or other nearby organs [14].
• Leg pain: Swelling and pain in the legs, known as edema, can be a sign of advanced disease [14].
• Heavy vaginal bleeding: Unusual vaginal bleeding, which may be heavy or prolonged, is a common symptom of cervical cancer [11].
• Loss of appetite and weight loss: As the cancer progresses, patients may experience a decrease in appetite and subsequent weight loss [4].
• Fatigue: Feeling extremely tired or weak can also occur due to the body's response to the disease [14].

Other Possible Symptoms

In addition to these common symptoms, some women with recurrent cervical cancer may experience:

• Urinary problems: Difficulty urinating or having a bowel movement can be caused by the spread of cancer cells to nearby organs [14].
• Blood in the urine: Blood in the urine can also occur due to the involvement of the urinary tract [14].

Importance of Early Detection

It's essential for women with a history of cervical dysplasia or cancer to undergo regular follow-up exams and Pap smears to detect any potential recurrences early on. If you have experienced symptoms like those mentioned above, it's crucial to consult a healthcare professional promptly.

References:

[4] - Symptoms of advanced cervical cancer may include loss of appetite, weight loss, fatigue, pelvic pain, back pain, leg pain, swollen legs, heavy vaginal bleeding [4]. [11] - Unusual vaginal bleeding, for example, after intercourse or between periods or after menopause [11]. [14] - Signs and symptoms of cervical cancer seen with more advanced disease can include: Swelling of the legs; Problems urinating or having a bowel movement; Blood in the urine [14].

Based on the provided context, it appears that you are looking for diagnostic tests related to a specific type of cervical cancer.

Diagnostic Tests

The diagnosis of cervical cancer typically involves a combination of clinical evaluation and laboratory tests. According to search result [6], diagnosis is usually made by cervical screening followed by a biopsy. Medical imaging may then be used to determine whether the cancer has spread.

Some diagnostic tests that may be used include:

• Pap smear: A Pap smear is a simple test that involves collecting cells from the cervix and examining them under a microscope for abnormal cell changes [3].
• HPV DNA testing: Human papillomavirus (HPV) DNA testing can help identify women who are infected with high-risk HPV types, which are associated with cervical cancer [2].
• Colposcopy: A colposcopy is a procedure that uses a special microscope to examine the cervix and vagina for abnormal cell changes [9].
• Biopsy: A biopsy involves taking a sample of tissue from the cervix or other areas affected by the cancer, which can then be examined under a microscope for cancer cells [6].

Other Tests

In addition to these tests, other diagnostic procedures may also be used, such as:

• Imaging studies: Imaging studies, such as ultrasound, MRI, or CT scans, may be used to determine whether the cancer has spread to other areas of the body [6].
• LBC (Liquid-Based Cytology) reports: LBC reports can provide information on abnormal cell changes and may indicate the presence of malignancy or cytologic findings suspicious for malignancy [9].

It's worth noting that the specific diagnostic tests used may vary depending on individual circumstances, such as the stage and type of cancer.

References:

[2] - Minimally abnormal screening results (HPV-positive negative for intraepithelial lesion or malignancy [NILM], HPV-positive ASC-US, HPV-positive LSIL), with low-...

[3] - Cervical cancer screening tests (e.g., the Papanicolaou (Pap) Test, HPV DNA, Thin-prep) reduce mortality from cervical cancer.

[6] - Diagnosis is typically by cervical screening followed by a biopsy. Medical imaging is then done to determine whether or not the cancer has spread.

[9] - An LBC report of malignancy or cytologic findings suspicious for malignancy was rendered in another 23%. Other serious abnormal LBC results, ...

Based on the available information, it appears that the treatment options for recurrent cervical cancer have evolved over time.

Current Treatment Options

According to recent studies [3][5], stage IVB cervical cancer is not usually considered curable. However, treatment options include chemotherapy alone or in combination with pembrolizumab if the tumor is PD-L1 positive [3]. Pembrolizumab has been shown to have efficacy in programmed death ligand 1 (PD-L1)–positive metastatic or unresectable cervical cancer that has progressed during chemotherapy [6].

Chemotherapy Options

Cisplatin-based combination chemotherapy has a response rate of 17-38% and a median overall survival of 6.1-7.1 months [2]. The combination of Platinol (cisplatin) and Gemzar (gemcitabine) appears to be an effective treatment option for recurrent cervical cancer, with one recent study demonstrating its efficacy [7][8].

Targeted Therapy

Pembrolizumab is an immunotherapy drug used to treat certain symptoms of recurrent cervical cancer and for late effects of treatment [4]. It has

Based on the provided context, it appears that you are looking for information on the differential diagnosis of a specific type of malignant endocervical neoplasm.

The differential diagnosis for this condition includes:

• Adenoid basal carcinoma: A rare neoplasm of the uterine cervix that accounts for less than 1% of cervical carcinomas [12]. It primarily affects postmenopausal women, although it has been reported in women as young as 20 years [3-7].
• HGSCs (High-Grade Serous Carcinomas) of the ovary: These can usually be distinguished based upon greater nuclear variability and high mitotic rate, and absence of squamous differentiation [14].
• Metastatic colon, endometrial, and endocervical adenocarcinomas: These should also be considered in the differential diagnosis [14].

Additionally, the context mentions that the glandular growth pattern is the most common type of malignant endocervical neoplasm, and that location is important to consider for the differential diagnosis.

It's worth noting that the success of screening for cervical cancer is largely dependent on the recognition of a well-defined preinvasive cancerous change defined as cervical intraepithelial neoplasia (CIN) [8].

References:

[3-7] Adenoid basal carcinoma accounts for less than 1% of cervical carcinomas, and primarily affects postmenopausal women, although it has been reported in women as young as 20 years.

[12] Branchial cleft cyst carcinoma is the result of malignant squamous cell degeneration of branchial remnants.

[14] Common differential diagnoses include HGSCs of the ovary, ovarian sex-cord tumors, and metastatic colon, endometrial, and endocervical adenocarcinomas.