obsolete speckled lentiginous nevus

Speckled Lentiginous Nevus: A Brief Overview

A speckled lentiginous nevus (SLN), also known as a nevus spilus, is a type of congenital melanocytic lesion that was previously considered to be a single clinical entity. However, recent studies have shown that it can be divided into two distinct disorders: naevus spilus maculosus and naevus spilus papulosus.

Historical Context

In the past, speckled lentiginous nevus was thought to represent one clinical entity, characterized by a hyperpigmented macule or patch containing scattered, dark, macular or papular foci. However, with further research, it has been found that this condition can manifest in two different forms: naevus spilus maculosus and naevus spilus papulosus.

Naevus Spilus Maculosus

This type of speckled lentiginous nevus is consistently found in phacomatosis spilorosea, a variety of pigmented noncancerous skin patches. It presents as a light-brown or tan macule with smaller, darker macules or papules.

Naevus Spilus Papulosus

This type of speckled lentiginous nevus is commonly found in phacomatosis pigmentokeratotica and is characterized by a papular form. It has been associated with melanoma in rare cases.

Evolution of Understanding

The understanding of speckled lentiginous nevus has evolved over time, with researchers now recognizing it as two distinct disorders rather than a single clinical entity. This shift in perspective has led to a more nuanced understanding of this condition and its various manifestations.

References: * Rudolf Happle. (2010). Speckled lentiginous nevi: no longer one single disorder. Arch Dermatol, 146(2), 204. * Other relevant sources within the provided context.

Speckled Lentiginous Nevus (SLN) - Obsolete Entity

The obsolete entity known as Speckled Lentiginous Nevus (SLN), also referred to as Naevus Spilus, is characterized by a distinct set of signs and symptoms. While it is no longer considered a single clinical entity, its characteristics can be summarized as follows:

• Macular Type: This type of SLN presents as a large, light-brown discoloration of the skin, often with scattered, dark macular or papular foci within its borders.
• Papulosus Type: In contrast, the papulosus type of SLN is characterized by a more pronounced papular component, with darker, more prominent papules scattered throughout the affected area.

Key Features

• The lesions are typically hyperpigmented and may be accompanied by smaller, darker macules or papules within their borders.
• They can appear as a single lesion or multiple lesions on different parts of the body.
• In some cases, SLN may be associated with other skin conditions or systemic disorders.

Important Considerations

• It is essential to note that SLN is no longer considered a distinct clinical entity, and its characteristics have been reclassified under other conditions.
• The diagnosis and management of SLN should be approached with caution, taking into account the latest medical knowledge and guidelines.

References:

[12] Speckled lentiginous naevus (synonym: naevus spilus) no longer represents one clinical entity, but rather, two different disorders can be distinguished. Naevus spilus maculosus is consistently found in phacomatosis spilorosea, whereas naevus spilus papulosus represents a hallmark of phacomatosis pigmentokeratotica.

[14] Speckled lentiginous nevus. A speckled lentiginous nevus (SLN), or nevus spilus (from the Greek word spilos, meaning spot), clinically appears as a hyperpigmented macule or patch containing scattered, dark, macular or papular foci.

[15] Speckled lentiginous naevus (synonym: naevus spilus) no longer represents one clinical entity, but rather, two different disorders can be distinguished. Naevus spilus maculosus is consistently found in phacomatosis spilorosea, whereas naevus spilus papulosus represents a hallmark of phacomatosis pig …

Diagnostic Tests for Speckled Lentiginous Nevus

Speckled lentiginous nevus (SLN), also known as nevus spilus, is a rare melanocytic lesion that requires strict histological criteria to make an accurate diagnosis. While there are no specific diagnostic tests for SLN, several methods can help distinguish it from other melanocytic lesions.

• Histopathological examination: A biopsy of the lesion is essential to confirm the diagnosis of SLN. Histopathological examination reveals varying histological patterns within the speckled areas, ranging from nevus incipiens to junctional and compound nevi (10).
• Immunohistochemistry tests: Due to similarities between adnexal tumors, diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests (2, 5, 9).
• Physical examination: A characteristic finding on physical examination is the presence of a light brown macule or patch containing smaller, more darkly pigmented macules or papules within the borders (11).

Key Points to Remember

• SLN is a rare melanocytic lesion that requires strict histological criteria for diagnosis.
• Histopathological examination and immunohistochemistry tests are essential for accurate diagnosis.
• Physical examination can help distinguish SLN from other melanocytic lesions.

References:

(2) Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours ... (5) Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours ... (9) by A Płatkowska · 2024 · Cited by 1 — Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours ... (10) The speckled areas show varying histological patterns that range from nevus incipiens to junctional and compound nevi. The background shows histological features of lentigo simplex. (11) A nevus spilus (NS) or speckled lentiginous nevus (SLN) typically presents before the age of 2 as a light brown macule or patch containing smaller, more darkly pigmented macules or papules within the borders.

Differential Diagnosis of Obsolete Speckled Lentiginous Nevus

Speckled lentiginous nevi, also known as naevus spilus, is a type of congenital melanocytic nevus that has been reclassified into two distinct disorders: naevus spilus maculosus and naevus spilus papulosus [13]. The differential diagnosis for these obsolete entities includes:

• Phacomatosis spilorosea: This condition is characterized by the presence of naevus spilus maculosus, which is consistently found in phacomatosis spilorosea [13].
• Phacomatosis pigmentovascularis: This condition is a rare genetic disorder that presents with a combination of melanocytic and vascular lesions, including speckled lentiginous nevi [14].
• Dysplastic nevus: Dysplastic nevi are a type of atypical mole that can be confused with speckled lentiginous nevi due to their similar appearance [15].
• Lentigines: Lentigines are small, benign melanocytic lesions that can be distinguished from speckled lentiginous nevi by the absence of nests and the presence of a more uniform pigmentation [15].

It is essential to note that the reclassification of speckled lentiginous nevus into two distinct disorders has led to changes in the differential diagnosis for these entities. A thorough understanding of the clinical presentation and histopathological features of naevus spilus maculosus and naevus spilus papulosus is crucial for accurate diagnosis.

References:

[13] Torres KG, Carle L, Royer M. Nevus spilus (speckled lentiginous nevus) in the oral cavity: report of a case and review of the literature. [14] Speckled lentiginous nevi: no longer one single disorder Arch Dermatol. 2010 Feb;146(2):204. doi: 10.1001/archdermatol.2009.393. [15] 42 year old man with speckled lentiginous nevus on trunk (Dermatology 2004;209:228) 45 year old man with melanoma (Int J Dermatol 2006;45:1362) ... Differential diagnosis. Dysplastic nevus; Lentigines: No nests, may be nevi if examine serial sections (Am J Dermatopathol 1985;7 Suppl:5)