You have 1 free disease view remaining today. Register for more view, it is 100% free →
obsolete acrosyringeal nevus
Description
Obsolete Acrosyringeal Nevus: A Rare Skin Condition
Acrosyringeal nevus, also known as eccrine syringofibroadenoma, is a rare benign tumor that affects the skin. It is characterized by the presence of proliferating ductular structures resembling the acral portion of the eccrine duct.
Key Features:
- Typically presents as solitary or multiple, coalescing, firm, pink or skin-coloured verrucous nodules of variable sizes
- Usually involves distal extremities
- Can be found on the sole of the foot, hand, or other areas of the body
Synonyms: Acrosyringeal nevus is also known by other names, including: * Acrosyringeal concentration of keratinocyte necrosis * Eccrine syringofibroadenomatous hyperplasia * Eccrine syringofibroadenoma * Acrosyringeal nevus (disorder)
References:
- Mascaro's first description in 1963 [11]
- Only around 50 cases have been reported globally [11]
- A histologic variant showing nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of eccrine syringoma has been described [12]
Note: The information provided is based on the search results and context, which may not be exhaustive or up-to-date. If you need more information or clarification, please let me know.
References: [11] Mascaro's first description in 1963 [12] A histologic variant showing nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of eccrine syringoma
Additional Characteristics
- Acrosyringeal nevus, also known as eccrine syringofibroadenoma, is a rare benign tumor that affects the skin.
- It presents as solitary or multiple, coalescing, firm, pink or skin-coloured verrucous nodules of variable sizes.
- Typically involves distal extremities and can be found on the sole of the foot, hand, or other areas of the body.
- There are only around 50 cases reported globally, with Mascaro's first description in 1963 being one of them.
- A histologic variant showing nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of eccrine syringoma has been described.
Signs and Symptoms
Common Signs and Symptoms of Acrosyringeal Nevus
Acrosyringeal nevus, also known as syringofibroadenoma, is a rare skin condition characterized by the presence of benign tumors on the skin. The signs and symptoms of this condition can vary depending on the individual, but here are some common ones:
- Bleeding on slight injury: This is a common sign of acrosyringeal nevus, where even minor injuries can cause bleeding (1).
- Crusting and scabbing: As growth progresses, crusting and scabbing may occur at the site of the tumor (5).
- Pain and discomfort: Some individuals may experience pain or discomfort in the affected area.
- Skin lesions: Acrosyringeal nevus is characterized by the presence of skin lesions, which can be benign or malignant.
Other Possible Signs and Symptoms
While not as common, other possible signs and symptoms of acrosyringeal nevus include:
- Redness and inflammation: The affected area may become red and inflamed.
- Itching and pruritus: Some individuals may experience itching or pruritus (itching) in the affected area.
Important Note
It's essential to note that these signs and symptoms can vary depending on the individual and the severity of the condition. If you suspect you have acrosyringeal nevus, it's crucial to consult a dermatologist for proper diagnosis and treatment.
References:
[1] by E NEVI — Bleeding on slight injury is a common sign. As growth progresses, crusting ... Dermatol Surg 2002;28:1168. [5] by E NEVI — Crusting and scabbing may occur at the site of the tumor (5).
Additional Symptoms
- Pain and discomfort
- Skin lesions
- Bleeding on slight injury
- Crusting and scabbing
- inflammation
- itching
Diagnostic Tests
Treatment
Based on the provided context, it appears that there are limited information available on the drug treatment of acrosyringeal nevus.
However, I found some relevant information in search results:
- There is no mention of any specific drug treatment for acrosyringeal nevus in the top 15 search results.
- However, in result #3, it mentions that a patient was prescribed etanercept 50 mg subcutaneously twice weekly for 6 weeks, which reduced the pruritus by 98%. This suggests that etanercept may be used to treat symptoms associated with acrosyringeal nevus, but it is not clear if it is specifically used to treat the condition.
- In result #8, it mentions treatment options for basal cell carcinoma, which includes minoxidil, androgen receptor antagonists (spironolactone, cyproterone acetate, flutamide), and the 5a-reductase inhibitor finasteride. However, there is no direct mention of these treatments being used for acrosyringeal nevus.
- In result #9, it mentions that topical therapy appears to be effective in treating basal cell carcinoma, but it does not provide any specific information on drug treatment for acrosyringeal nevus.
Based on the available information, it seems that there is limited evidence on the use of drug treatment specifically for acrosyringeal nevus. However, some treatments mentioned above may be used to manage symptoms associated with the condition.
Possible Treatment Options:
- Etanercept (result #3) - may be used to treat symptoms such as pruritus
- Minoxidil, androgen receptor antagonists (spironolactone, cyproterone acetate, flutamide), and finasteride (result #8) - may be used to manage symptoms associated with basal cell carcinoma, but their effectiveness in treating acrosyringeal nevus is unclear
- Topical therapy (result #9) - may be effective in treating basal cell carcinoma, but its use for acrosyringeal nevus is not established
Note: The above information is based on the provided context and search results. It is essential to consult a medical professional for accurate and personalized advice on treatment options.
Differential Diagnosis
Differential Diagnosis of Acrosyringeal Nevus
Acrosyringeal nevus, also known as eccrine syringofibroadenoma (ESFA), is a rare benign adnexal tumor. When diagnosing this condition, it's essential to consider the differential diagnosis, which includes other conditions that may present similarly.
Differential Diagnosis:
- Acrosyringeal nevus: This is the primary condition being discussed.
- Fibroepithelial tumor of Pinkus: A rare skin tumor that can be distinguished from acrosyringeal nevus by its histopathological features, including local changes typical of basal cell carcinoma [13].
- Eccrine poroma: A benign adnexal tumor that can be differentiated from acrosyringeal nevus by its histopathological characteristics and clinical presentation [11].
- Syringofibroadenocarcinoma: A rare malignant skin tumor that can be distinguished from acrosyringeal nevus by its aggressive behavior and histopathological features [11].
Key Features for Differential Diagnosis:
To differentiate acrosyringeal nevus from other conditions, the following key features should be considered:
- Histopathological characteristics: Acrosyringeal nevus is characterized by nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of eccrine syringoma [11].
- Clinical presentation: The clinical presentation of acrosyringeal nevus can include a verrucoid lesion on the right calcaneus and a second nonfriable lesion on the dorsolateral aspect of the foot [15].
Conclusion:
In conclusion, when diagnosing acrosyringeal nevus, it's essential to consider the differential diagnosis, which includes other conditions that may present similarly. By considering the key features for differential diagnosis, including histopathological characteristics and clinical presentation, a accurate diagnosis can be made.
References:
[11] Eccrine syringofibroadenoma (acrosyringeal nevus) is a rare tumor of proliferating ductular structures resembling the acral portion of the eccrine duct. [13] The histopathological differential diagnosis may include acrosyringeal nevus, fibroepithelial tumor of Pinkus, eccrine poroma, and syringofibroadenocarcinoma. [15] ESFA also called an acrosyringeal nevus, is a rare benign adnexal tumor which was first described by Mascaro.
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:12864
- core#notation
- DOID:12864
- oboInOwl#hasExactSynonym
- Acrosyringeal nevus (disorder)
- rdf-schema#label
- obsolete acrosyringeal nevus
- owl#deprecated
- true
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_8234
Medical Disclaimer: The information provided on this website is for general informational and educational purposes only.
It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.