obsolete Reoviridae infectious disease

Based on the provided context, it appears that there are multiple mentions of an "obsolete" Reoviridae infectious disease.

• According to search result [3], the term ID for this disease is DOID:1334.
• Search result [4] also mentions this disease as a synonym for "disease due to Orthoreovirus", "disease due to Reoviridae (disorder)", and "disease due to Rotavirus".
• However, it's worth noting that search results [3] and [4] seem to be duplicates of each other.

Unfortunately, there is no further information provided in the context about this specific disease. The only additional details are mentions of Reoviridae infections in general, but not specifically about an obsolete infectious disease.

If you're looking for more information on this topic, I'd be happy to try and search again or provide a summary based on what's available!

Based on the provided context, it appears that there are several signs and symptoms associated with Reoviridae infectious diseases, which were once considered relevant but may be less so in modern times.

• Clinical findings:
  • Uneven or retarded growth (71% of infected flocks) [9]
  • Wet litter and/or lameness (71% of infected flocks) [9]
  • Diarrhea is the most common clinical sign in ratite chicks [8]
• General symptoms:
  • High fever, tachypnoea, stridor, and excessive drooling [7]
  • Low-grade fever, abdominal pain, watery diarrhea, nausea, and vomiting [4]
  • Profuse, non-bloody diarrhea (lasting 4-5 days) [5]
• Other symptoms:
  • Vomiting, usually short-lived, can occur before or after the onset of diarrhea [11]
  • Symptoms of an apparent respiratory infection may be present [11]

It's essential to note that these signs and symptoms are associated with Reoviridae infectious diseases, which were once considered relevant but may be less so in modern times. The context suggests that some of these diseases have been largely eradicated or their impact has decreased significantly.

References: [7], [8], [9], [11]

Reoviridae Infectious Disease Diagnostic Tests

The diagnostic tests for Reoviridae infectious diseases have evolved over time, with various methods being used to detect and diagnose these infections. Here are some of the diagnostic tests that were once used for Reoviridae infectious diseases:

• Immunohistologic test: This test was used to detect early viral antigens in cells after 24 hours (Source: [2]). However, due to the virus variability, this test became difficult and laboratory-specific.
• Molecular classification: Molecular tests were used to classify Reoviridae infectious diseases, but these tests were costly and complex (Source: [4]).
• Serum antibody measurement: Serum antibodies were measured to detect infections caused by Reoviridae viruses. However, the accuracy of this method was limited due to the variability of the virus.
• Virus particle detection: Virus particles were detected using electron microscopy, which provided a direct visualization of the virus (Source: [1]). However, this method was not widely used due to its complexity and cost.

Current Diagnostic Tests

While these diagnostic tests are no longer commonly used for Reoviridae infectious diseases, they provide valuable insights into the history of diagnostic testing for these infections. Modern diagnostic tests have evolved to include more accurate and reliable methods, such as:

• Reverse-transcription polymerase chain reaction (RT-PCR): This test is a rapid and reliable method for detecting Reoviridae viruses (Source: [9]).
• Phylogenetic analysis: Phylogenetic analysis is used to classify Reoviridae infectious diseases based on the genetic characteristics of the virus.

References

[1] by P Roingeard · 2019 · Cited by 99 [2] [4] by KR Pritchett-Corning · 2009 · Cited by 315 [9] by H Ishiko · 2002 · Cited by 218

Based on the provided context, it appears that there are various treatments for diseases caused by viruses belonging to the Reoviridae family.

• Reovirus treatment: According to search result 9, reovirus treatment was well tolerated in metastatic melanoma patients. However, I could not find any information about drug treatment of obsolete Reoviridae infectious disease.
• Antiviral drugs: Search result 10 mentions that antiviral drugs are used to treat Reoviridae infections. These include inhibitors of viral RNA polymerase, viral protein synthesis inhibitors, inhibitors of viral entry, and immunomodulators.

Some specific antiviral drugs mentioned in the context include:

• Podofilox: This is an FDA-approved drug that acts as an immunomodulatory agent to treat human papillomavirus (HPV) infections. [1]
• Sinecatechins: Another FDA-approved drug, sinecatechins are used to treat HPV infections and work by acting as antimitotic agents. [2]
• Imiquimod: This is a topical cream that acts as an immunomodulatory agent to treat HPV infections. [3]

Other treatments mentioned in the context include:

• Reolysin: This is a drug that has been used in combination with paclitaxel and carboplatin to treat metastatic/recurrent KRAS-mutated or epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer. [7]
• Inosine pranobex: This is an immunomodulatory drug that has been approved in several countries for the treatment of viral infections, including influenza and HIV. [6]

It's worth noting that the context also mentions various other treatments and drugs, but I could not find any information about drug treatment of obsolete Reoviridae infectious disease.

References:

[1] by EM Karapanagiotou · 2012 · Cited by 202 — Reovirus type-3 Dearing (RT3D) systemic administration has shown evidence of antitumor activity with a favorable toxicity profile as monotherapy or combined ...

[2] by E De Clercq · 2016 · Cited by 1528 — Instead of targeting HPV proteins, sinecatechins work by inhibiting the proliferation of cancer cells.

[3] by T. S. Dermody · 2021 — Imiquimod is a topical cream that acts as an immunomodulatory agent to treat HPV infections.

[4] by Hoorieh Soleimanjahi · 2022 — The Reoviridae family has a wide host range, consisting of vertebrates, insects, and plants.

[5] by Laban NM · 2022 — T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review.

Understanding Differential Diagnosis

A differential diagnosis is a process of identifying and ruling out other possible causes of a disease or condition, in this case, an obsolete Reoviridae infectious disease.

Relevant Information from Search Results

According to search result [3], Reovirus 81-176 was inoculated subcutaneously into day-old specific-pathogen-free leghorns and evaluated for its effects on the immune system. This suggests that Reoviruses can affect various species, including birds.

Search result [5] mentions Astrovirus infection as a differential diagnosis to be considered in patients with viral gastroenteritis. While not directly related to Reoviridae, it highlights the importance of considering other viral infections when diagnosing gastrointestinal diseases.

Differential Diagnoses for Obsolete Reoviridae Infectious Disease

Based on search results [7] and [15], differential diagnoses for an obsolete Reoviridae infectious disease may include:

• Mouse coronaviruses
• EDIM virus
• Salmonella spp.
• Clostridium piliforme

These pathogens can cause similar symptoms, such as diarrhea and gastrointestinal issues, making them potential candidates for differential diagnosis.

Prevention and Control

Search result [15] mentions that surviving mice appear to recover completely from infection, but the potential for a carrier state exists. This implies that prevention and control measures may be necessary to prevent further transmission of the disease.

Conclusion

In conclusion, when considering a differential diagnosis for an obsolete Reoviridae infectious disease, it is essential to rule out other possible causes, such as mouse coronaviruses, EDIM virus, Salmonella spp., or Clostridium piliforme. Prevention and control measures may also be necessary to prevent further transmission of the disease.

References:

[3] RD Montgomery · 1986 · Cited by 51 [5] 1 Epidemiology and clinical significance. [7] Oct 22, 2024 [15] Jan 19, 2019