obsolete lymphoma by site

Obsolete Lymphomas by Site

Lymphomas are a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). Over time, some classifications of lymphomas have become outdated or replaced with more accurate terminology. Here's an overview of obsolete lymphomas by site:

• Hodgkin's lymphoma: This category includes several subtypes that are no longer used in modern classification systems.
  • Nodular sclerosis: Involving lymph nodes of multiple sites [4]
  • Mixed cellularity: Involving spleen [6]
  • Lymphocyte-rich: A rare subtype [11]
• Non-Hodgkin lymphoma: This category also includes several subtypes that are no longer used.
  • Nodular/follicular Histiocytic Diffuse Lymphocytic poorly differentiated: An antiquated term for a mixture of small and large lymphocytes [2]
  • Angiocentric immunoproliferative lesion and angiocentric lymphoma: These terms have been replaced due to the vagueness in distinguishing between these cancers and leukemias [7]

It's essential to note that modern classification systems, such as the World Health Organization (WHO) classification, have replaced these outdated terms with more accurate and specific diagnoses.

References

• [2] An antiquated term for a mixture of small and large lymphocytes.
• [4] Involving lymph nodes of multiple sites.
• [6] Involving spleen.
• [7] The terms angiocentric immunoproliferative lesion and angiocentric lymphoma have become obsolete.

Common Signs and Symptoms of Lymphoma

Lymphoma, a type of cancer that affects the immune system, can manifest in various ways depending on its location in the body. Here are some common signs and symptoms associated with lymphoma by site:

• Head and Neck: Lymphoma in this region can cause cranial nerve palsies, facial pain, hearing loss, vertigo, proptosis (bulging eyes), or visual disturbances [8].
• Chest and Abdomen: Symptoms often include cough, shortness of breath (dyspnea) and chest tightness. Other areas of the body such as the skin, central nervous system, kidneys and bones can also be affected [9].
• Skin: Lymphoma can cause itching, redness, or swelling on the skin [7].
• Central Nervous System: Symptoms may include anemia, bleeding, increased susceptibility to infections, loss of appetite, fatigue, respiratory distress, or itching [7].
• Kidneys and Bones: Pain in these areas can be a symptom of lymphoma [9].

General Symptoms

In addition to site-specific symptoms, lymphoma can also cause general symptoms such as:

• Night sweats
• Persistent fevers
• Unexplained weight loss
• Fatigue
• Itchy skin
• Painless swelling of lymph nodes in the neck, groin or underarm

It's essential to note that these symptoms can be similar to those of other conditions, and a healthcare professional should be consulted for proper diagnosis and treatment.

References:

[7] Signs and symptoms · Anemia, bleeding, increased susceptibility to infections · Loss of appetite or anorexia · Fatigue · Respiratory distress or dyspnea · Itching [8] Mar 5, 2024 — Lymphoma involving the base of the skull or CNS can cause cranial nerve palsies, facial pain, hearing loss, vertigo, proptosis, or visual ... [9] Symptoms often include cough, shortness of breath (dyspnea) and chest tightness. Other areas of the body such as the skin, central nervous system, kidneys and ...

Diagnostic Tests for Obsolete Lymphomas

Lymphomas are a type of cancer that affects the immune system, and there are several types of lymphomas that have been classified as obsolete due to advances in medical knowledge. Diagnostic tests play a crucial role in identifying these cancers and determining their stage.

• Biopsy: A biopsy is the most accurate diagnostic test for lymphoma. It involves removing a sample of tissue from the affected area, which is then examined

Based on the provided context, here are some treatment options for obsolete lymphomas by site:

• Non-Hodgkin Lymphoma (NHL) PEN (prednisolone etoposide mitozantrone): This combination was discontinued [7].
• Primary CNS Lymphoma: Treatment options include chemotherapy, radiation, and targeted therapy [3].

It's worth noting that the treatment landscape for lymphomas is constantly evolving, and new therapies are being developed. However, these specific combinations have been discontinued or are no longer considered standard treatments.

References:

[7] Non-Hodgkin lymphoma PEN (prednisolone etoposide mitozantrone) DISCONTINUED · Non-Hodgkin lymphoma POMP maintenance therapy DISCONTINUED. Primary CNS lymphoma. [3] B-cell non-Hodgkin lymphoma treatment options include chemotherapy, radiation, targeted therapy, plasmapheresis, surveillance, ...

Differential Diagnosis of Lymphoma by Site

Lymphoma can present differently depending on the site of involvement. Here are some possible differential diagnoses for lymphoma based on the affected site:

• Peripheral cervical and inguinal lymph nodes: The more frequently affected sites, although central lymph nodes, including abdominal and thoracic, can also be involved [1]. In these cases, the differential diagnosis may include conditions such as metastatic disease, pyelonephritis, renal abscess, and IgG4-related renal disease [8].
• Central lymph nodes (abdominal and thoracic): These sites are less frequently affected but can still present with lymphoma. The differential diagnosis in these cases may include conditions such as RCCs, metastatic disease, pyelonephritis, renal abscess, and IgG4-related renal disease [7].
• Blood, bone marrow, spleen, and/or other tissues: Lymphoma can also involve the blood, bone marrow, spleen, and/or other tissues. In these cases, the differential diagnosis may include conditions such as leukemia or myeloproliferative neoplasms [5].

Key Points to Consider

• Biopsy is essential to establish a diagnosis of lymphoma [4].
• Obtain an excisional biopsy (or, if that is not possible, a core