obsolete leukemic reticuloendotheliosis of lymph nodes of inguinal region and lower limb

Definition and Description

Leukemic reticuloendotheliosis, also known as

Based on the search results, here are the signs and symptoms of leukemic reticuloendotheliosis (LRE) that may affect the lymph nodes in the inguinal region and lower limb:

• Swollen lymph nodes: Lymph nodes in the neck, armpits, or groin can become swollen due to LRE. In some cases, these swollen lymph nodes can be found in the inguinal region (groin area) [11].
• Abdominal distension: Marked abdominal distension with a spleen tip palpable has been reported in patients with LRE [2, 4]. This may indicate involvement of the spleen and potentially affect the lymph nodes in the lower limb.
• Bruising and petechiae: Physical examination revealed multiple petechiae (tiny red spots) and bruising in the upper and lower extremities in some cases of LRE [2, 4].
• Lymphadenopathy: Swollen lymph nodes can be found in various regions, including the inguinal region, due to LRE. This is a common symptom in many types of leukemia, including LRE [11].

It's essential to note that these symptoms may not be specific to leukemic reticuloendotheliosis and can be associated with other conditions as well.

References:

[2] by AE Johnson · 2022 · Cited by 4 [4] by AE Johnson · 2023 · Cited by 4 [11] Symptoms. Leukemia symptoms vary, depending on the type of leukemia. Common leukemia signs and symptoms include: ... Swollen lymph nodes, enlarged liver or spleen; Easy bleeding or bruising; Recurrent nosebleeds; Tiny red spots in your skin ...

Based on the search results, it appears that diagnostic tests for leukemic reticuloendotheliosis (LRE) have evolved over time.

Traditional Diagnostic Tests:

• Bone marrow biopsy was a common diagnostic tool to confirm the presence of LRE and exclude other diagnoses [2].
• Blood smears were prepared and stained for various enzymes, such as alkaline phosphatase, acid phosphatase, nonspecific esterase, periodic acid Schiff, toluidine blue, and iron, to aid in diagnosis [1].

Modern Diagnostic Tests:

• Fine needle punctures of lymph nodes, liver, spleen, bone marrow, thoracic or abdominal effusions allow for immediate cytological analyses [7].
• These tests can help confirm the presence of LRE and provide information on the extent of disease spread.

Other Relevant Information:

• Leukemic reticuloendotheliosis is a rare type of chronic leukemia with an incidence of approximately 2% of all leukemias seen at some hospitals each year [15].
• The diagnosis of LRE was based on histopathology of spleen tissue and bone marrow biopsy specimens in the past [6].

It's worth noting that modern diagnostic tests have likely replaced some of these traditional methods, but the exact details are not provided in the search results.

Based on the search results, it appears that leukemic reticuloendotheliosis is a rare neoplastic disease of the hematopoietic system. However, I couldn't find any specific information on the drug treatment for this condition in the context provided.

But, I can tell you that according to [10], Leukemic reticuloendotheliosis (LRE) is a rare neoplastic disease of the hematopoietic system that is characterized clinically by a chronic course, splenomegaly in the absence of substantial lymphadenopathy, and pancytopenia.

Regarding treatment options, I found some information on [3] which mentions that combination of either of the nucleoside analogues with rituximab is suggested for those relapsing before two years. However, this information does not specifically mention drug treatment for leukemic reticuloendotheliosis of lymph nodes of inguinal region and lower limb.

It's worth noting that [8] mentions concerns over the use of triple therapy in treating certain conditions, but it does not provide specific information on the treatment of leukemic reticuloendotheliosis.

Unfortunately, I couldn't find any relevant information on the drug treatment for this specific condition. However, I can suggest searching again or asking a different question if you'd like.

Here are some possible treatment options that might be considered:

• Combination therapy with nucleoside analogues and rituximab (as suggested in [3])
• Intensive leukopheresis (as mentioned in [13])
• Other treatments may vary depending on the specific case and patient's condition

Please note that these suggestions

Based on the search results, I was able to find some relevant information on the differential diagnosis of leukemic reticuloendotheliosis of lymph nodes of inguinal region and lower limb.

Differential Diagnosis

The differential diagnosis for leukemic reticuloendotheliosis of lymph nodes of inguinal region and lower limb includes:

• Metastatic visceral neuroendocrine carcinomas [4]
• Cutaneous lymphoma [4]
• Dermatologic manifestations of other hematologic malignancies [12]

It is also helpful to consider infective lymphadenitis in several categories, including regional lymphadenitis [8].

Other Conditions

Other conditions that may be considered in the differential diagnosis include:

• Lymphadenopathy and lymphadenitis [9]
• Leukemic infiltration of lymph nodes [10]
• Lymphosarcoma or equivalent description (complete loss of normal architecture) [10]

It is worth noting that confusion in semantics and lack of pathologic criteria have hampered a wider recognition of leukemic reticuloendotheliosis as a distinct clinicopathological entity [12].

References

[4] Prakash A. Hairy cell leukemia (HCL) and Merkel cell carcinoma (MCC) are two rare malignancies with distinct cells of origin. [8] I Yonal-Hindildren. We describe an unusual case of hairy cell leukemia (HCL) in a 55-year-old male presenting with isolated skeletal disease as the initial manifestation. [9] S Sahai. Introduction. Lymphadenopathy is defined as an abnormality in size and consistency of lymph nodes, while the term lymphadenitis refers to... [10] I Yonal-Hindildren. We describe an unusual case of hairy cell leukemia (HCL) in a 55-year-old male presenting with isolated skeletal disease as the initial manifestation. [12] S Sahai. Introduction. Lymphadenopathy is defined as an abnormality in size and consistency of lymph nodes, while the term lymphadenitis refers to...