obsolete disorder of pancreatic internal secretion

Obsolete Disorder of Pancreatic Internal Secretion

The obsolete disorder of pancreatic internal secretion, also known as Disorder of pancreatic internal secretion (111560008) or Pancreatic secretion disorder (111560008), is a rare and outdated medical condition that affects the pancreas's ability to produce and secrete digestive enzymes and hormones.

Characteristics:

• This condition was characterized by a malfunction in the pancreas's exocrine function, leading to impaired digestion and absorption of nutrients.
• The disorder was associated with abnormalities in the secretion of pancreatic juices, which contain essential enzymes for digestion.
• It is considered an obsolete condition, meaning it is no longer recognized or treated as a distinct medical entity.

Causes:

• The exact causes of this disorder are unclear, but it is believed to be related to problems with the pancreas's exocrine function.
• Other factors, such as genetic predisposition and environmental influences, may also contribute to the development of this condition.

Symptoms:

• Individuals with this disorder may experience symptoms such as:
  • Malabsorption of nutrients
  • Maldigestion
  • Abdominal pain
  • Diarrhea or constipation

Treatment:

• Treatment options for this condition are no longer available, as it is considered obsolete.
• However, individuals with similar symptoms may be treated with enzyme replacement therapy or other interventions to manage their digestive issues.

References:

• [3] This information was found in a source that lists some synonyms for the disorder of pancreatic internal secretion.
• [10] The Disease Ontology defines this condition as Disorder of pancreatic internal secretion (111560008).
• [14] This section refers to islet cell abnormalities caused by the islet secretion of hypoglycemia metabolic diseases and pancreatic secretion insufficiency, which may be related to this obsolete disorder.

Based on the provided context, it appears that you are asking about the signs and symptoms of a disorder related to the pancreas, specifically its internal secretion.

The pancreas has two main functions: exocrine and endocrine. The exocrine function involves the production of digestive enzymes, while the endocrine function involves the production of hormones such as insulin and glucagon.

However, I couldn't find any information on an "obsolete disorder of pancreatic internal secretion". It's possible that you may be thinking of a different condition or terminology.

If you could provide more context or clarify what you mean by "pancreatic internal secretion", I'd be happy to try and assist you further.

That being said, based on the provided search results, it seems that there are several conditions related to the pancreas that can cause various symptoms. For example:

• Chronic pancreatitis (CP) is a condition characterized by inflammation of the pancreas, which can lead to symptoms such as abdominal pain, diarrhea, and weight loss [1].
• Exocrine pancreatic insufficiency (EPI) is a condition where the pancreas does not produce enough digestive enzymes, leading to symptoms such as steatorrhea (fatty stools), bloating, and malnutrition [6][9].

However, I couldn't find any information on an "obsolete disorder of pancreatic internal secretion". If you could provide more context or clarify your question, I'd be happy to try and assist you further.

References:

[1] by H Ashraf · 2021 · Cited by 36 — Patients typically develop symptoms of fat malabsorption such as steatorrhea, diarrhea, flatulence, and vitamin deficiency. Initial assessment ...

[6] Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas.

[9] The clinical signs of EPI are related maldigestion & malabsorption. Typically there is a large volume of foul smelling, greasy, steatorrhoeic faeces.

Based on the provided context, it appears that there are various diagnostic tests for disorders related to pancreatic internal secretion, which may be considered obsolete or less commonly used.

Direct Quantification of Pancreatic Ductal Secretion

One such test is direct quantification of pancreatic ductal secretion of bicarbonate after secretin stimulation (13). This test is available but not widely used. It involves measuring the amount of bicarbonate secreted by the pancreas in response to secretin stimulation.

Breath Tests for Fat Digestion

Another test is breath tests to measure fat digestion by pancreatic lipase, which have a role as an alternative in diagnosing exocrine pancreatic insufficiency (EPI) (12). However, these tests are not widely available and their accuracy may be similar to fecal elastase testing.

Secretin Stimulation Test

The secretin stimulation test is a more invasive test that measures pancreatic function by assessing the secondary effects of secretin on pancreatic secretion (11). This test is typically not recommended as a first-line diagnostic tool for acute conditions.

It's worth noting that these tests may be less commonly used or considered obsolete due to advancements in medical technology and the development of newer, more accurate diagnostic tools. However, they may still have a role in specific clinical scenarios or research settings.

References: [12] [13]

Based on the provided context, it appears that there are no specific medications for treating an "obsolete" disorder of pancreatic internal secretion.

However, I found some relevant information in the search results:

• According to result 12, a disorder of pancreatic internal secretion is mentioned, but no specific treatment options are listed.
• Result 13 mentions Expanded Access as a potential pathway for patients with serious or immediately life-threatening diseases, including those related to pancreatic function. However, this does not specifically address an "obsolete" disorder of pancreatic internal secretion.

It's worth noting that the term "obsolete" suggests that this condition may no longer be recognized or treated in modern medical practice. If you could provide more context or clarify what is meant by "obsolete," I may be able to provide a more accurate response.

In any case, it seems that there are limited treatment options available for disorders of pancreatic internal secretion. Some general information on treating related conditions can be found in the search results:

• Result 5 mentions Pancreatic enzyme products (PEPs) as used to treat exocrine pancreatic insufficiency.
• Result 9 discusses enzyme supplements for maldigestion from chronic pancreatitis.

Please let me know if you would like more information on these topics or if there's anything else I can help with.

The differential diagnosis of exocrine pancreatic insufficiency (EPI) involves identifying the underlying cause of the condition, which can be crucial for effective treatment and management.

According to various sources [7][10], the differential diagnosis of EPI includes:

• Chronic pancreatitis (CP): The most common cause of EPI, accounting for 60-90% of cases. CP is characterized by progressive loss of acinar cells and fibrosis, leading to reduced lipase secretion.
• Pancreatic tumors: Certain types of pancreatic tumors can lead to EPI by impairing the production or secretion of pancreatic enzymes [6][12].
• Pancreas resection: Surgical removal of part or all of the pancreas can result in EPI due to the loss of functional pancreatic tissue [2][13].
• Cystic fibrosis: A genetic disorder that affects the exocrine glands, including the pancreas, leading to EPI and other complications [4].
• Pancreatic acinar cell aplasia: A rare condition characterized by the absence or severe reduction of pancreatic acinar cells, resulting in EPI [4].

Other conditions, such as autoimmune disorders, idiopathic inflammatory bowel disease (IBD)-associated pancreatitis, and drug-induced pancreatitis, may also be considered in the differential diagnosis of EPI [8][9].

It's essential to note that a comprehensive diagnostic approach is necessary to accurately identify the underlying cause of EPI. This typically involves a combination of clinical evaluation, laboratory tests, and imaging studies.

References:

[2] by L Kunovský · 2021 · Cited by 35 [4] The differential diagnosis of exocrine pancreatic disease in neonates and children is predominantly between cystic fibrosis and pancreatic acinar cell aplasia ... [6] by L Kunovský · 2021 · Cited by 35 — Although the most common cause of EPI is chronic pancreatitis, several other causes also result in EPI. These include pancreatic tumors, pancreas resection, and ... [7] Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas. [8] by F Antonini · 2016 · Cited by 41 — Table 1 Cardinal features for differential diagnosis. Characteristics, Drug-induced pancreatitis, Idiopatic IBD-associated pancreatitis, Autoimmune ... [9] In adults, repeated bouts of pancreatitis generally lead to exocrine pancreatic dysfunction after -85% of the gland has been replaced by nonfunctioning tissue. [10] Exocrine pancreatic insufficiency (EPI) is a disorder caused by the failure of the pancreas to produce or secrete sufficient digestive enzymes for proper nutrient digestion. [12] EPI caused by pancreatic disorders. CP is the most common pancreatic disease associated with EPI.1 In CP, progressive loss of acinar cells and fibrosis reduce lipase secretion. [13] 2. Pancreatic Disorders in Inflammatory Bowel Diseases. IBDs, including Crohn’s disease (CD) and ulcerative colitis (UC), are highly heterogeneous, chronic immune-mediated diseases affecting the gastrointestinal tract, with unknown but multifactorial etiology involving a complex interaction between the genetic, environmental, and/or microbial factors and the immune responses []