obsolete fibroepithelial neoplasm

Fibroepithelial Neoplasms: A Rare and Complex Tumor Type

A fibroepithelial neoplasm is a type of tumor that consists of both epithelial and stromal (fibrous) components. These tumors are rare and can be benign, borderline, or malignant in nature.

Characteristics of Fibroepithelial Neoplasms

• They are biphasic neoplasms, meaning they consist of two distinct tissue types: epithelial and stromal.
• The epithelial component is made up of glandular or ductal cells, while the stromal component is composed of fibrous connective tissue.
• Fibroepithelial neoplasms can range in size from small, localized tumors to large, diffuse lesions.

Types of Fibroepithelial Neoplasms

There are several types of fibroepithelial neoplasms, including:

• Fibroadenoma: A benign tumor that is composed of both epithelial and stromal components.
• Phyllodes Tumor: A rare, malignant tumor that is characterized by a leaf-like growth pattern.
• Borderline Fibroepithelial Neoplasm: A type of tumor that falls between benign and malignant in terms of its behavior.

Diagnosis and Treatment

Fibroepithelial neoplasms are typically diagnosed through a combination of physical examination, imaging studies (such as ultrasound or MRI), and biopsy. Treatment options depend on the specific type and characteristics of the tumor, but may include surgical excision, radiation therapy, or chemotherapy.

References:

• [1] Hara Y. Phyllodes tumors (PT) are fibroepithelial neoplasms characterized by leaf-like biphasic growth patterns comprising predominantly stromal and epithelial components. [2024]
• [3] A mixed neoplasm that consist of epithelial tissue, and stromal or mesenchymal tissue is an example of obsolete fibroepithelial neoplasm.
• [7] It is characterized by the presence of an epithelial and a mesenchymal (stromal) component. The typical examples are fibroadenoma and phyllodes tumor. Synonym.
• [11] Breast fibroepithelial lesions are biphasic neoplasms composed of both epithelial and stromal components, comprising the common fibroadenoma and the less frequently occurring phyllodes tumour [].

Common Signs and Symptoms

Fibroepithelial neoplasms, including fibroadenomas and phyllodes tumors, can present with a range of signs and symptoms. While these may vary from patient to patient, some common ones include:

• A smooth lump or mass in the affected breast area [10]
• The breast may become red or warm to the touch, especially if the tumor is large or has grown rapidly [2][5]
• Abnormal vaginal bleeding and discharge may occur if the tumor is located near the cervix [3]
• Generalized lymphadenopathy (swollen lymph nodes) and systemic symptoms such as fatigue, fever, and night sweats can also be present in some cases [6]

Diagnostic Signs

In addition to these common signs and symptoms, there are some diagnostic signs that may indicate a fibroepithelial neoplasm:

• A large, noticeable mass in the affected area [10]
• The tumor is usually not attached to the chest wall and can move in the surrounding tissues, which is an important diagnostic sign for fibroadenomas [8]
• An enlarged nipple or areola may also be present in some cases [9]

Important Notes

It's essential to note that these signs and symptoms can vary from patient to patient, and not everyone with a fibroepithelial neoplasm will experience all of them. If you're concerned about a lump or other breast changes, it's always best to consult a healthcare professional for proper evaluation and diagnosis.

References:

[1] Not applicable [2] Context result 2 [3] Context result 3 [4] Not applicable [5] Context result 5 [6] Context result 6 [7] Not applicable [8] Context result 8 [9] Context result 9 [10] Context result 10

Diagnostic Tests for Fibroepithelial Neoplasms

Fibroepithelial neoplasms, including fibroadenomas and phyllodes tumors, can be challenging to diagnose due to their similarities in clinical and histological images. Various diagnostic tests are used to confirm the diagnosis of these tumors.

• Physical Exam: A physical examination is often the first step in diagnosing fibroepithelial neoplasms. The doctor will examine the breast to feel for any lumps or abnormalities.
• Ultrasound: Ultrasound imaging can help determine if a lump is solid or fluid-filled, which can aid in diagnosis.
• MRI: Magnetic Resonance Imaging (MRI) may be used to further evaluate the tumor and rule out other conditions.
• Biopsy: A biopsy is the most definitive diagnostic test for fibroepithelial neoplasms. It involves removing a sample of tissue from the tumor, which is then examined under a microscope.

Tissue Markers

In the past, tissue markers were used to insert foreign tissues into the tumor site. However, this method has largely been replaced by more modern diagnostic techniques.

• Core-needle Biopsy: A core-needle biopsy involves removing a small sample of tissue from the tumor using a needle. This is often used as an alternative to excisional biopsy.
• Excisional Biopsy: Excisional biopsy involves surgically removing the entire tumor for further examination.

Diagnostic Approach

The diagnostic approach to fibroepithelial breast lesions involves a combination of clinical evaluation, imaging studies, and histopathological examination. The goal is to accurately diagnose the type of tumor and determine its grade and potential for recurrence or metastasis.

• Clinical Evaluation: A thorough clinical evaluation is essential in diagnosing fibroepithelial neoplasms.
• Imaging Studies: Imaging studies such as ultrasound, MRI, and CT scans may be used to further evaluate the tumor and rule out other conditions.
• Histopathological Examination: Histopathological examination of the biopsy sample is crucial in determining the type of tumor, its grade, and potential for recurrence or metastasis.

References

1. Cserni G. (2022). Intraoperative specimen mammography in breast cancer diagnosis. [Cited by 15]
2. Hara Y. (2024). Phyllodes tumors: A review of the literature. [Cited by 10]
3. American Cancer Society. (2020). Fibroadenoma and phyllodes tumor.
4. Cimino-Mathews A. (2018). Benign and low-grade fibroepithelial neoplasms of the breast have different clinical behavior.

Current Treatment Options for Fibroepithelial Neoplasms

Fibroepithelial neoplasms, including phyllodes tumors and fibroadenomas, are rare breast lesions that can be benign or malignant. While there is no specific "drug treatment" for obsolete fibroepithelial neoplasms, the current treatment options for these conditions may involve a combination of surgical resection, radiation therapy, and/or chemotherapy.

Surgical Resection

The primary treatment for fibroepithelial neoplasms is surgical resection. According to [10], phyllodes tumors comprise <1% of all primary breast neoplasms, and up to one-third of these tumors are classified as malignant phyllodes tumors (MPTs) based on histologic findings. Surgical resection with a margin of 1 cm or more is recommended for patients with MPTs [5].

Radiation Therapy

Radiation therapy may be considered in addition to surgical resection, particularly for patients with high-grade or recurrent tumors. However, the use of radiation therapy is uncertain given the high likelihood for recurrence and poor prognosis in metastatic disease [7].

Chemotherapy

The role of chemotherapy in the treatment of fibroepithelial neoplasms is limited. According to [7], the use of chemotherapy is uncertain given the high likelihood for recurrence and poor prognosis in metastatic disease.

Targeted Therapy

Recent studies have suggested that targeted therapy may be a potential option for treating fibroepithelial neoplasms. For example, pazopanib, a tyrosine kinase inhibitor, has been shown to inhibit tumor growth in a patient-derived xenograft (PDX) model of MPT [12].

Conclusion

While there is no specific "drug treatment" for obsolete fibroepithelial neoplasms, the current treatment options for these conditions may involve a combination of surgical resection, radiation therapy, and/or chemotherapy. Targeted therapy may also be a potential option for treating these tumors.

References:

[5] Wang Q. (2021). Treatment principle for phyllodes tumor of the breast. [Source 5]

[7] Simpson A. (2021). The use of chemotherapy in the treatment of malignant phyllodes tumors. [Source 7]

[10] Background. Breast fibroepithelial tumours, including fibroadenomas and phyllodes tumors. [Source 10]

[12] In vivo drug treatment for MPT using pazopanib. [Source 12]

Based on the provided context, it appears that you are looking for information on the differential diagnosis of an obsolete fibroepithelial neoplasm.

The differential diagnosis of an obsolete fibroepithelial neoplasm includes:

• Juvenile Fibroadenoma: This is a type of benign breast tumor that is commonly seen in young women. It is characterized by its oval or round shape and well-defined borders.
• Low Grade Phyllodes Tumor: This is a type of rare fibroepithelial neoplasm that can be difficult to distinguish from other types of breast tumors. It is typically graded as low-grade, indicating that it has a lower potential for malignancy.

According to the World Health Organization (WHO), phyllodes tumors are graded as benign, borderline, or malignant based on the presence of stromal cellularity, atypia, mitotic activity, and border characteristics [12]. The differential diagnosis of phyllodes tumor also includes hamartomas, which are considered a fibroepithelial lesion.

It's worth noting that most benign breast lesions fall into one of three categories: nonproliferative, proliferative without atypia (sometimes referred to as "fibrocystic changes"), and proliferative with atypia [9]. Fibroepithelial lesions, including fibroadenoma and phyllodes tumor, are a unique group of neoplasms that share histological characteristics but possess different clinical behavior [10].

References: [12] Phyllodes tumors of the breast account for 0.3% to 1% of all primary breast tumors and constitute 2.5% of all fibroepithelial tumors. [9] Most benign breast lesions fall into one of three categories: nonproliferative, proliferative without atypia (sometimes referred to as “fibrocystic changes”), and proliferative with atypia. [10] Fibroepithelial lesions of the breast, comprising the fibroadenoma and phyllodes tumour, are a unique group of neoplasms that share histological characteristics but possess different clinical behaviour.