obsolete secondary malignant neoplasm of retroperitoneum and peritoneum

Obsolescence of Secondary Malignant Neoplasm of Retroperitoneum and Peritoneum

The term "secondary malignant neoplasm of retroperitoneum and peritoneum" is considered outdated in modern medical terminology. This condition refers to a type of cancer that has spread to the retroperitoneal and peritoneal regions, but it is now more accurately described using specific codes and classifications.

• C48.2: Malignant neoplasm of peritoneum, unspecified
• C78.6: Secondary malignant neoplasm of retroperitoneum and peritoneum

These codes are used in the International Classification of Diseases (ICD) system to classify and code various types of cancer, including secondary malignant neoplasms.

Current Terminology

The current terminology for this condition is more specific and detailed. It involves the use of exact synonyms and classifications to describe the type of cancer and its location. For example:

• A primary or metastatic malignant neoplasm involving the retroperitoneum (result 3)
• Malignant neoplasm of retroperitoneum and peritoneum (result 6)

These terms provide a more accurate and detailed description of the condition, allowing for better communication and understanding among healthcare professionals.

References

[1] Result 3: A primary or metastatic malignant neoplasm involving the retroperitoneum. [2] Result 6: Malignant neoplasm of retroperitoneum and peritoneum. [3] Result 8: C48.2 Malignant neoplasm of peritoneum, unspecified. [4] Result 78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum.

Common Signs and Symptoms

Secondary malignant neoplasm of the retroperitoneum and peritoneum can exhibit a range of symptoms, which may vary depending on the location and size of the tumor. Some common signs and symptoms include:

• Abdominal Mass: A palpable mass in the abdominal region is often one of the first noticeable symptoms [3].
• Weight Loss: Unintentional weight loss due to decreased appetite or difficulty eating can occur as the disease progresses [4].
• Pain: Abdominal pain, particularly in the lower quadrants, can be a symptom of secondary malignant neoplasm of the retroperitoneum and peritoneum [3].
• Bloating and Swelling: Fluid accumulation in the abdominal cavity can cause bloating and swelling, leading to discomfort and difficulty breathing [5].
• Fatigue: As the disease advances, patients may experience fatigue due to anemia or other complications [4].

Additional Symptoms

In some cases, secondary malignant neoplasm of the retroperitoneum and peritoneum can lead to additional symptoms, such as:

• Obstructive Phenomena: The tumor can cause obstruction of vital structures, leading to symptoms like constipation, urinary retention, or difficulty swallowing [13].
• Respiratory Distress: Fluid accumulation in the lungs can cause respiratory distress, requiring immediate medical attention [12].

It's essential to note that these symptoms may not be specific to secondary malignant neoplasm of the retroperitoneum and peritoneum. A proper diagnosis can only be made by a qualified healthcare professional through a combination of physical examination, imaging studies, and laboratory tests.

References:

[3] - Context result 3 [4] - Context result 4 [5] - Context result 8

Diagnostic Tests for Secondary Malignant Neoplasms of Retroperitoneum and Peritoneum

The diagnosis of secondary malignant neoplasms of the retroperitoneum and peritoneum can be challenging, but various diagnostic tests can help confirm the presence of cancer in these regions. Here are some of the diagnostic tests that may be used:

• Imaging Tests: Imaging tests such as CT scans, MRI scans, and PET/CT scans can help capture fine details of the abdominal cavity and pinpoint the location of cancer cells and potential metastases [8]. A CT scan is considered the best imaging procedure for evaluating patients with known or suspected peritoneal metastases [7].
• Ultrasound: Ultrasound tests, such as transvaginal ultrasound, can also be used to detect ascites or growths in the abdominal cavity [5].
• Blood Tests: Blood tests, such as the CA-125 test, can measure levels of a chemical in the blood that may indicate peritoneal or ovarian cancer [10]. However, it's essential to note that elevated levels do not necessarily confirm the presence of cancer.
• Ascitic Fluid Analysis: In some cases, needle drainage of ascitic fluid for analysis may be required to confirm the diagnosis [2].
• Keyhole Surgery: Keyhole surgery or laparoscopy can also be used to visualize the abdominal cavity and obtain tissue samples for further examination.

It's worth noting that a combination of these diagnostic tests may be necessary to confirm the presence of secondary malignant neoplasms in the retroperitoneum and peritoneum. A thorough evaluation by a healthcare professional is essential to determine the best course of action for each individual case.

References:

[1] Ultrasound can show differences between healthy tissues and cancerous tumors. [2] Imaging (such as CT or MRI scans), needle drainage of ascitic fluid for analysis, keyhole surgery, or a combination of these may be required to confirm the diagnosis. [3] by CM Patel · 2011 · Cited by 132 — This article reviews established and new techniques in CT, MRI and PET imaging in both primary and secondary peritoneal malignancies [4] Patients have either a CT scan or MRI of the abdomen and pelvis to confirm the presence of new or recurrent disease in the peritoneum. [5] How is peritoneal cancer diagnosed? · An X-ray of the chest or abdominal cavity · An abdominal or transvaginal ultrasound, which uses sound waves to create images [6] May 22, 2019 — Imaging tests of the abdomen and pelvis. This may show ascites or growths. Tests include CT scan, ultrasound, and MRI. [7] by JC Healy · 2001 · Cited by 40 — CT is considered the best imaging procedure for the evaluation of patients with known or suspected peritoneal metastases. [8] Diagnosis · Imaging tests like CT or MRI scans capture fine details of the abdominal cavity and help doctors pinpoint the location of cancer cells and potential metastases [9] by J Miguez González · 2023 · Cited by 17 — PET/CT is a highly accurate technique for ruling out nodal and extraperitoneal disease and detecting recurrences that may go unnoticed on CT, [10] Sep 22, 2023 — CA-125 blood test. This test measures levels of a chemical in the blood called CA-125. If levels are high, peritoneal or ovarian cancer may be present.

Based on the search results, it appears that there are various treatment options available for secondary malignant neoplasms of the retroperitoneum and peritoneum.

Chemotherapy

• Systemic chemotherapy is one of the treatment options for secondary malignant neoplasm of retroperitoneum and peritoneum. Chemotherapy drugs can be given intravenously or in combination with oral tablets to target cancer cells (5).
• Bevacizumab, a monoclonal antibody, can also be used as part of chemotherapy to treat some advanced primary peritoneal carcinoma (7).

Targeted Therapy

• Targeted therapy may be used to treat some advanced primary peritoneal carcinoma. Sometimes, targeted therapy drugs are combined with chemotherapy drugs (7).
• Alemtuzumab is a targeted therapy drug that has been studied in clinical trials for the treatment of pseudomyxoma peritonei and secondary malignant neoplasm of retroperitoneum (6).

Other Treatments

• Intestinal & Multivisceral Transplantation may be considered as an option for unresectable mucinous carcinoma peritonei (9).
• Surgery, neoadjuvant therapies, and a multidisciplinary approach are also used to treat retroperitoneal sarcoma (12).

It's worth noting that the effectiveness of these treatment options can vary depending on individual circumstances. It's essential to consult with a healthcare professional for personalized advice.

References:

[5] - Systemic chemotherapy: Chemotherapy drugs given intravenously or sometimes in combination with oral tablets circulate through the body to target cancer cells. [6] - Alemtuzumab Not Yet Recruiting Phase 2 Trials for Pseudomyxoma Peritonei / Secondary Malignant Neoplasm of Retroperitoneum / Secondary Peritoneal Neoplasm [7] - Targeted therapy may be used to treat some advanced primary peritoneal carcinoma. Sometimes a targeted therapy drug is combined with a chemotherapy drug. [9] - NCT06084780. Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE). Alemtuzumab · Sirolimus · Tacrolimus. [12] - Learn about the rare and challenging tumor retroperitoneal sarcoma, which can have different histologic subtypes and prognoses. Find out how to diagnose, stage, and treat this disease with surgery, neoadjuvant therapies, and multidisciplinary approach.

Based on the search results, it appears that differential diagnosis for secondary malignant neoplasm of retroperitoneum and peritoneum involves considering various conditions.

• Osteosarcoma: This is a type of bone cancer that can be considered in the differential diagnosis, especially if there are features such as solid mass-like enhancement on imaging studies [6].
• Osteomyelitis: This is an infection of the bone and bone marrow that can also present with similar imaging findings, but is less likely to be malignant.
• Eosinophilic granuloma: This is a type of cancer that affects the bone and can be considered in the differential diagnosis, especially if there are features such as solid mass-like enhancement on imaging studies [6].
• Retroperitoneal sarcoma: This is a rare type of cancer that originates from soft tissues in the retroperitoneum and can be considered in the differential diagnosis.
• Primary peritoneal tumors: These are rare neoplasms that arise from the malignant transformation of cells located in the mesothelial or submesothelial layers of the peritoneum [13].

It's worth noting that the best diagnostic technique for secondary malignant neoplasm of retroperitoneum and peritoneum is computed tomography (CT), which can show a fibrotic soft-tissue mass, infiltrating the retroperitoneum and enveloping the retroperitoneal organs [8].