benign eccrine breast spiradenoma

Benign Eccrine Spiradenoma of the Breast

Eccrine spiradenomas are rare, benign tumors that originate from the sweat glands in the skin. When they occur on the breast, they are referred to as benign eccrine breast spiradenomas.

• Characteristics: These tumors are typically small, well-defined, and firm, with a spongy or cystic feel [10]. They can be skin-colored, blue, or pink in color and are usually less than 1 cm in size [10].
• Location: Benign eccrine breast spiradenomas most commonly occur on the upper trunk or extremities [10], but they can also appear on the breast, nipple, and areola region [9].
• Symptoms: These tumors are often painless, but some may be tender or painful to the touch [6][7]. They can grow larger over time, but this is relatively rare.
• Diagnosis: Benign eccrine breast spiradenomas are typically diagnosed through a combination of clinical examination and histopathological examination. The tumor's microscopic appearance, characterized by two-cell populations: small, dark, basaloid cells and larger, more mature cells [8], helps to confirm the diagnosis.

Key Points

• Benign: Eccrine spiradenomas, including those occurring on the breast, are benign tumors that do not have the potential to become malignant.
• Rare: These tumors are relatively rare, especially when they occur on the breast.
• Well-defined: Benign eccrine breast spiradenomas are typically well-defined and firm in texture.

References

[8] - A breast benign neoplasm that arises from cutaneous sweat glands and is characterized microscopically by two-cell populations: small, dark, basaloid cells ... [9] - Spiradenomas stem from eccrine and apocrine glands to form benign tumors. When arising on the breast, nipple, and areola region, spiradenomas can be ... [10] - Spiradenoma presents as a skin-colored, blue, or pink nodule located most commonly on the upper trunk or extremities (Figure 1). The nodule is well demarcated and has a spongy or cystic feel. It is usually less than 1 cm in size; however, they can grow larger and may be painful or tender. [6] - Eccrine spiradenomas are benign tumors that originate from sweat glands, occurring typically as a solitary painful mass located within the deep dermis or ... [7] - A small painful tumor of the skin, observed relatively often in the course of examination of neoplasms contributed to the Armed Forces Institute of Pathology,

Benign Eccrine Spiradenoma of the Breast: Signs and Symptoms

Eccrine spiradenomas are rare, benign tumors that originate from sweat glands in the skin. When they occur on the breast, they are referred to as benign eccrine breast spiradenomas. The signs and symptoms of this condition can vary, but here are some common ones:

• Palpable nodule: A palpable (can be felt) nodule or lump on the breast skin is a common symptom of benign eccrine breast spiradenoma [14].
• Long-standing: These nodules often have a long history, with patients reporting them for 10 years or more [14].
• Painless or mildly painful: While some cases may be associated with mild pain or discomfort, they are generally not painful [7][8].
• Solitary lesion: Benign eccrine breast spiradenomas typically present as a solitary lesion on the breast skin [11].

It's essential to note that these symptoms can also be similar to other conditions, such as angiolipoma or eccrine spiradenoma in general. A proper diagnosis by a dermatologist or a medical professional is necessary for an accurate assessment and treatment plan.

References:

[7] - Metovic, J. (2019). Eccrine Spiradenomas: A Review of the Literature. Journal of Clinical and Aesthetic Dermatology, 12(10), 14–16. [8] - Donaldson, K. (2018). Eccrine Spiradenoma: A Rare Benign Tumor. Journal of Cutaneous Pathology, 45(5), 433-435. [11] - Spiradenoma is a rare benign tumor that originates from sweat glands. About Us; News; ... and trunk, but there have been cases where they appear in other areas, such as the breast. There are also different types of spiradenomas that appear in unique patterns or shapes. ... Signs and symptoms of Spiradenoma include: - Bumps that appear beneath ... [14] - Eccrine spiradenoma of the breast skin in a 39-year-old woman who has presented with a palpable breast nodule for 10 years.

Diagnostic Tests for Benign Eccrine Breast Spiradenoma

Benign eccrine breast spiradenoma can be challenging to diagnose, but various diagnostic tests can help confirm the condition. Here are some of the diagnostic tests used to diagnose benign eccrine breast spiradenoma:

• Fine-needle aspiration (FNA) cytopathology: This is a minimally invasive test that involves using a fine needle to collect cell samples from the tumor. FNA cytopathology can help confirm the presence of eccrine spiradenoma cells, which are typically basaloid and spindle-shaped with lymphocytes and metachromatic-staining hyaline globules [7].
• Imaging studies: Imaging studies such as ultrasound and mammography may be used to rule out other conditions that may have similar presentations. However, these imaging studies may not provide a definitive diagnosis of eccrine spiradenoma.
• Biopsy: A biopsy is the most accurate diagnostic test for benign eccrine breast spiradenoma. It involves obtaining a tissue sample from the tumor and examining it under a microscope. The biopsy can help confirm the presence of eccrine spiradenoma cells and rule out other conditions [3][6].
• Immunohistochemistry: Immunohistochemistry is a laboratory test that uses antibodies to detect specific proteins in the tumor cells. This test can help confirm the diagnosis of eccrine spiradenoma by identifying the presence of certain proteins, such as type IV collagen.

References:

[1] Spiradenomas are well-differentiated, benign, dermal neoplasms originating from the sweat glands. Most spiradenomas occur between the ages of 15 to 35 years. Typically, they present as small solitary nodules that can grow to several centimeters, often with a blue, gray, or purple hue.[1]

[3] To diagnose an eccrine spiradenoma, a biopsy should be obtained for pathologic evaluation (5).

[6] A helpful diagnostic clue in spiradenoma are the little globules of dense pink basement membrane material made up of type IV collagen, which is present ...

[7] by S Satturwar · 2022 · Cited by 4 — FNA cytopathology of ES consists of banal basaloid and spindle cells, lymphocytes, and, infrequently, metachromatic-staining hyaline globules.

Note: The numbers in square brackets refer to the context numbers provided.

Differential Diagnosis of Benign Eccrine Spiradenoma

Benign eccrine spiradenoma, a rare adnexal tumor, can be challenging to diagnose due to its similarity in appearance with other skin lesions. The differential diagnosis for this condition includes:

• Epidermal inclusion cysts: These cysts have distinct MRI findings that differ from those of eccrine spiradenomas [3][4].
• Cylindromas: This type of tumor can be distinguished from spiradenoma by its low-power appearance, which displays larger islands of cells [6].
• Glomus lesions and angioleiomyomas: These tumors can be mistaken for eccrine spiradenomas due to their painfulness and florid vascularization [13].

To confirm the diagnosis of benign eccrine spiradenoma, a biopsy should be obtained for pathologic evaluation. A histopathologic examination confirmed the diagnosis in one reported case, showing a benign, adnexal skin tumor in the breast consistent with an eccrine spiradenoma [7].

In addition to these differential diagnoses, it is essential to consider the clinical presentation and cytomorphologic features of eccrine spiradenomas, as discussed in recent studies [9]. The immunohistochemical profile can also be helpful