obsolete Rhabdoviridae infectious disease

Based on your query, I will provide information about an obsolete infectious disease caused by a virus belonging to the family Rhabdoviridae.

The Disease: One such disease is Vesicular Stomatitis (VSV). However, it's worth noting that VSV is still present in some parts of the world and can cause significant economic losses in the livestock industry.

• Characteristics: VSV is a viral disease that affects cattle, pigs, horses, and other mammals. It causes fever, vesicles or blisters on the skin, and lesions in the mouth and nose.
• Transmission: The virus is transmitted through direct contact with infected animals, contaminated feed or water, and fomites (inanimate objects).
• Symptoms: Infected animals may exhibit symptoms such as fever, lethargy, loss of appetite, and skin lesions. In severe cases, the disease can lead to death.
• Treatment: There is no specific treatment for VSV, but supportive care such as providing food and water, and administering antibiotics to prevent secondary infections can help manage the disease.

Other Obsolete Diseases: Another example of an obsolete infectious disease caused by a virus belonging to the family Rhabdoviridae is Rabies. However, it's worth noting that Rabies is still present in some parts of the world and can cause significant human deaths if not treated promptly.

• Characteristics: Rabies is a viral disease that affects mammals, including humans. It causes inflammation of the brain and is almost always fatal if left untreated.
• Transmission: The virus is transmitted through the saliva of infected animals, usually through bites.
• Symptoms: Infected individuals may exhibit symptoms such as fever, headache, agitation, and paralysis.
• Treatment: Prompt medical attention, including post-exposure prophylaxis (PEP) with rabies immunoglobulin and vaccination, can prevent the disease if administered promptly after exposure.

References:

1. [1] Vesicular Stomatitis Virus. (n.d.). Retrieved from https://www.cdc.gov/vsv/index.html 2.

Initial Symptoms

The initial symptoms of diseases caused by viruses in the family Rhabdoviridae, such as rabies, typically include fever, discomfort, headache, and pain or paraesthesia at the site of infection. These symptoms can progress to more severe neurological damage, including hyperactivity, aggression, and confusion.

• Fever is often one of the first signs of illness, followed by pain or paraesthesia at the wound site [2].
• The initial symptoms of rabies resemble those of other systemic viral infections, including fever, headache, malaise, and upper respiratory and gastrointestinal symptoms [6].
• Clinical signs of rabies start out like the flu, including general weakness or discomfort, fever, or headache [7].

Progression of Symptoms

As the disease progresses, more severe neurological symptoms can develop, including:

• Seizures and convulsions
• Delirium and confusion
• Painful muscle spasms in the throat
• Difficulty swallowing
• Paralysis and weakness

Based on the provided context, it appears that there are various diagnostic tests for Rhabdoviridae infectious diseases, including rabies. Here's a summary of the relevant information:

• Direct Fluorescent Antibody (DFA) test: This is the most widely used test for rabies diagnosis and is recommended by both WHO and OIE [1]. It involves testing directly on a brain impression smear.
• Other diagnostic tests: These include direct rapid immunohistochemistry test (dRIT), pan-lyssavirus reverse-transcription, and virus isolation/culture [2].
• Specimens for antemortem diagnosis: Serum, cerebrospinal fluid (CSF), saliva, and tissue from highly innervated anatomical areas are the appropriate biological specimens for antemortem diagnosis [6].
• **Confirmatory

Treatment Options for Obsolete Rhabdoviridae Infectious Diseases

The Rhabdoviridae family includes several viruses that were once prevalent but are now considered obsolete due to advances in medicine and public health measures. Some examples include:

• Rabies: A viral disease caused by Lyssavirus, a member of the Rhabdoviridae family.
• Duck plague: A viral disease caused by the Duck plague virus (DPV), also known as the Alpharhabdovirus.

Treatment Options

While these diseases are now considered obsolete in many parts of the world, treatment options were available in the past. Here are some of them:

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Based on the provided context, it appears that you are looking for information on the differential diagnosis of an outdated or obsolete infectious disease caused by the Rhabdoviridae family.

The search results suggest that rabies is a fatal, acute, progressive encephalomyelitis caused by neurotropic viruses in the family Rhabdoviridae. However, it's essential to note that the term "obsolete" might refer to an outdated or less commonly discussed disease within this family.

Considering the context provided, one possible differential diagnosis for an obsolete Rhabdoviridae infectious disease could be:

• Rabies: Although not entirely obsolete, rabies is a fatal, acute, progressive encephalomyelitis caused by neurotropic viruses in the family Rhabdoviridae. It's essential to consider this possibility when evaluating patients with symptoms such as alteration in mood, hallucinations, and bizarre behavior (1).
• Other Lyssavirus infections: The genus Lyssavirus within the family Rhabdoviridae includes several other viruses that can cause similar symptoms to rabies. These include the Lagos bat virus, the Mokola virus, and the Duvenhage virus, among others (3, 7, 9).
• Vesiculovirus infections: The genus Vesiculovirus within the family Rhabdoviridae also includes viruses that can cause similar symptoms to rabies. These include the vesicular stomatitis virus and the Chandipura virus (8).

It's crucial to note that these differential diagnoses are based on the assumption that the obsolete disease is caused by a member of the Rhabdoviridae family. Further investigation and consultation with relevant experts would be necessary to confirm or rule out these possibilities.

References:

• [1] Rabies is a fatal, acute, progressive encephalomyelitis caused by neurotropic viruses in the family Rhabdoviridae.
• [3] The causes of rabies are RNA viruses belonging to the genus lyssavirus within the family Rhabdoviridae, order Mononegavirales.
• [7] Rabies virus. The causes of rabies are RNA viruses belonging to the genus lyssavirus within the family Rhabdoviridae, order Mononegavirales.
• [8] The Rhabdoviridae are a family of more than 140 different viral species, including the vesicular stomatitis virus and the Chandipura virus.
• [9] Rabies has the highest case fatality rate of any human infectious disease.