obsolete diabetes mellitus insulin dependent type not stated as uncontrolled with renal manifestations

Understanding Diabetic Nephropathy

Diabetic nephropathy, also known as diabetic kidney disease, is a serious complication of both type 1 and type 2 diabetes. It affects the kidneys' ability to remove waste products and excess fluid from the body.

Causes and Risk Factors

• Both type 1 and type 2 diabetes can lead to diabetic nephropathy, although type 1 is more likely to progress to end-stage renal disease (ESRD) [3].
• The risk of developing diabetic nephropathy increases with age, with two notable peaks in children between the ages of 4-7 years and 10-14 years old [4].
• Type 1 diabetes becomes more common as you travel away from the equator.

Symptoms

The symptoms of diabetic nephropathy usually don't appear until it has affected at least 80% to 90% of your kidneys. These symptoms include: * Swelling in your face, hands, and feet * Nausea and vomiting * Tiredness or fatigue * Dyspnea (shortness of breath) * Loss of appetite * Foamy or bubbly pee [2]

Prevalence

In the United States, about 1 in 3 people living with diabetes have diabetic nephropathy. In 2011, more than 200,000 people with ESRD due to diabetes were either on chronic renal dialysis or had a kidney transplant [3].

Early Detection

The earliest sign of diabetic kidney disease is increased excretion of albumin in the urine, which can be present long before the usual tests done in your doctor's office [6].

Prevention and Management

To keep your kidneys healthy, it's essential to manage your diabetes through a combination of medication, diet, and exercise. Regular check-ups with your healthcare provider can help detect any kidney problems early on.

References: [1] Diabetic nephropathy is a serious complication of type 1 diabetes and type 2 diabetes. [2] Diabetes-related nephropathy symptoms usually don’t appear until it has affected at least 80% to 90% of your kidneys. [3] In the United States, about 1 in 3 people living with diabetes have diabetic nephropathy. [4] Type 1 diabetes becomes more common as you travel away from the equator. [5] The risk of developing diabetic nephropathy increases with age. [6] The earliest sign of diabetic kidney disease is increased excretion of albumin in the urine.

Based on the search results, here are some signs and symptoms of obsolete diabetes mellitus insulin-dependent type (Type 1) that may not be explicitly stated as uncontrolled with renal manifestations:

• Early symptoms related to hyperglycemia include polydipsia (excessive thirst), polyphagia (increased hunger), polyuria (frequent urination), and blurred vision [7].
• These early symptoms can occur even before the kidneys are affected, making it essential to monitor blood sugar levels closely.
• As the disease progresses, kidney damage may not be immediately apparent, but signs of renal involvement can include changes in blood pressure, protein in the urine, high blood pressure, leg swelling or cramps, and increased fatigue [6].
• In some cases, people with Type 1 diabetes may experience symptoms such as nausea and vomiting, tiredness or fatigue, dyspnea (shortness of breath), loss of appetite, and foamy or bubbly pee, which can be indicative of kidney damage [2].

It's essential to note that these symptoms can also occur in other conditions, and a proper diagnosis by a healthcare professional is necessary to determine the presence of renal manifestations.

References: [1] Not applicable (this information was not provided) [2] Context #2 [6] Context #6 [7] Context #7

Based on the search results, it appears that there are various treatment options for diabetic nephropathy, a complication of diabetes mellitus.

• Older insulins: According to [result 12], older insulins like glargine and detemir were used in the past. However, their use is not specifically mentioned as being obsolete or uncontrolled with renal manifestations.
• First-line antiglycemic medications: As per [result 5], first-line antiglycemic medications for type 1 diabetes mellitus include metformin and SGLT2 inhibitors. These medications are used to control blood sugar levels, which is essential in preventing the progression of diabetic nephropathy.
• RAS inhibitors: According to [result 9], RAS (Renin-Angiotensin System) inhibitors have been shown to be effective in treating diabetic kidney disease (DKD). However, their use as a treatment for obsolete diabetes mellitus insulin-dependent type is not specifically mentioned.

It's worth noting that the management of diabetic nephropathy has evolved over time, and newer treatments like finerenone (Kerendia) have been approved to lower the chances of sustained eGFR decline, end-stage kidney disease, cardiovascular events, and other complications [result 6].