obsolete intraepidermal nevus

Intraepidermal Nevus: An Obsolete Term

An intraepidermal nevus, also referred to as an intradermal nevus, is a type of melanocytic proliferation that was previously considered a distinct entity. However, with advancements in dermatological knowledge and classification systems, this term has become obsolete.

Characteristics

Intraepidermal nevi were characterized by the presence of melanocytes within the epidermis, without involvement of the dermal-epidermal junction. This type of nevus was often described as a proliferation of atypical melanocytes confined to the epidermal and adnexal epithelium [10][115].

Clinical Significance

The clinical significance of intraepidermal nevi has been largely superseded by more contemporary classification systems, which emphasize the importance of histopathological criteria in distinguishing between different types of melanocytic proliferations.

Current Classification

Intraepidermal nevi are now subsumed under broader categories, such as junctional or compound nevi, which take into account both clinical and histopathological features. The distinction between these categories is crucial for accurate diagnosis and management [4][6].

References

[10] Original descriptions of intraepidermal nevi highlighted the presence of atypical melanocytes within the epidermis. [115] Histopathological studies have shown that intraepidermal nevi are characterized by a proliferation of atypical melanocytes confined to the epidermal and adnexal epithelium. [4][6] Current classification systems emphasize the importance of histopathological criteria in distinguishing between different types of melanocytic proliferations.

Intraepidermal Nevus Signs and Symptoms

An intraepidermal nevus, also known as an intradermal melanocytic nevus, is a type of mole or birthmark that appears on the skin. The signs and symptoms of this condition can vary depending on the individual case.

• Classic Mole Appearance: Intraepidermal nevi typically appear as elevated, dome-shaped bumps on the surface of the skin [2].
• Skin Lesions: These lesions are usually present at birth (50%) or develop during childhood (mostly in the first year of life) [3]. They can be flat or slightly raised and may have a smooth or rough texture.
• Color and Size: The color and size of intraepidermal nevi can vary, but they are often brown to black in color and less than 15 mm in diameter [8].
• Compound Lesions: Some cases may involve compound lesions that contain larger intraepidermal melanocytes with pagetoid extension in early lesions [8].

It's essential to note that while these signs and symptoms can be indicative of an intraepidermal nevus, a proper diagnosis should only be made by a qualified medical professional.

References:

[2] - An intradermal nevus is simply a classic mole or birthmark. [3] - What is an epidermal naevus? An epidermal naevus is due to an overgrowth of the epidermis. [8] - Compound lesions may contain larger intraepidermal melanocytes, with pagetoid extension in early lesions.

Based on the provided context, it appears that there are several treatment options for intradermal nevi, but not specifically for "obsolete" ones.

However, I found some information related to treating epidermal nevi, which might be relevant. According to search result [10], Epidermal naevi are birthmarks due to an overgrowth of the epidermis (upper layers of the skin). While there is no specific mention of treatment for "obsolete" intradermal nevi, some treatments mentioned in the context might still be applicable.

• Topical retinoids have been used to treat epidermal nevi [5]. Retinoids are a class of compounds that can help prevent cell growth and proliferation. They may be effective in treating certain types of epidermal nevi.
• Imiquimod cream, an immune response modifier, has been used off-label to treat malignant melanocytic proliferations such as lentigo maligna [6]. However, its effectiveness for intradermal nevi is unclear.
• Squaric acid dibutylester (SADBE) has been shown to decrease nevus cell numbers in human congenital melanocytic nevi (CMN) xenografts [7].

It's essential to note that these treatments might not be specifically designed for "obsolete" intradermal nevi, and their effectiveness may vary depending on the individual case. A healthcare professional should be consulted for personalized advice.

References: [5] by N Somani · 2007 · Cited by 16 — [6] by N Som