adenofibroma

Adenofibroma: A Benign Tumor

Adenofibroma is a rare, benign surface epithelial-stromal neoplasm composed of both epithelial and stromal components [1]. It can occur in various parts of the body, including the ovaries, uterus, cervix, and endometrium.

Characteristics

• Adenofibromas are typically solid or cystic tumors with a well-defined border [3].
• They may feel rubbery or like a marble, and can be flat, like a coin [5].
• The tumor is usually painless and non-cancerous (benign) [6, 7].

Types of Adenofibroma

• Ovarian adenofibromas are rare and often resemble low-grade müllerian adenosarcomas [1].
• Uterine adenofibromas are benign neoplasms with a sessile or papillary architecture, usually seen in post-menopausal women [15].

Differential Diagnosis

• Adenofibroma must be differentiated from endometrial polyp, hyperplasia, and carcinoma [14].
• It can also be confused with other benign tumors, such as fibroadenomas [2, 4].

Microscopic Description

• Adenofibromas are characterized by a single-layered epithelial lining with occasional stratification [10, 11].
• The stroma is typically fibromatous and variably cellular, with or without luteinization [12].

Overall, adenofibroma is a rare and benign tumor that can occur in various parts of the body. Its characteristics and types are distinct from other tumors, and it requires careful differential diagnosis to rule out more serious conditions.

References:

[1] Context result 1 [2] Context result 3 [3] Context result 5 [4] Context result 7 [5] Context result 9 [6] Context result 11 [7] Context result 13 [8] Context result 15

Adenofibroma Signs and Symptoms

A fibroadenoma, also known as an adenofibroma, is a solid breast lump that often causes no pain. The symptoms are typically minimal or absent, but can include:

• A small, firm, movable, round, rubbery, and smooth lump in the breast [9]
• The lump may be tender or cause soreness a few days before your period [1]
• Fibroadenomas may grow slowly over time, with an average size of about 1 inch (2.5 centimeters) [1]

It's essential to note that adenofibromas are noncancerous and usually do not cause any symptoms other than the lump itself [6]. However, if you notice a change in your breast that's new or unusual for you, it's always best to consult with your GP.

Key Points:

• Adenofibroma is a solid breast lump
• Typically causes no pain
• May be tender or cause soreness before menstruation
• Lump may grow slowly over time
• Usually noncancerous and does not increase the risk of developing breast cancer [5]

References:

[1] Context result 1: Symptoms of adenofibroma [6] Context result 6: A fibroadenoma is not usually painful or tender to the touch. [9] Context result 9: Typically, the only symptom of a fibroadenoma is a small lump in the breast that is: Firm; Movable; Round; Rubbery; Smooth.

Diagnostic Tests for Adenofibroma

Adenofibroma, also known as fibroadenoma, is a benign (non-cancerous) tumor that can occur in the breast. To diagnose adenofibroma, several diagnostic tests are used to confirm the presence of the tumor and rule out any potential cancer.

• Imaging Studies: Imaging studies such as ultrasound or magnetic resonance imaging (MRI) scans are often used to visualize the size, shape, and location of the tumor [1]. These tests can help determine if the lump is a fibroadenoma or something else.
• Histopathological Biopsy: A histopathological biopsy is the conclusive diagnostic test for adenofibroma. This involves removing a sample of tissue from the tumor and examining it under a microscope to confirm the presence of the tumor [2].
• Preoperative Laboratory Tests: Preoperative laboratory tests, such as cancer antigen (CA) 125, CA 19-9, and alpha-fetoprotein, may be performed to rule out any potential cancer [3].

Diagnostic Process

The diagnostic process for adenofibroma typically involves a combination of imaging studies and histopathological biopsy. The following steps are usually taken:

1. Imaging Studies: Imaging studies such as ultrasound or MRI scans are used to visualize the tumor.
2. Histopathological Biopsy: A sample of tissue is removed from the tumor and examined under a microscope to confirm the presence of adenofibroma.
3. Preoperative Laboratory Tests: Preoperative laboratory tests may be performed to rule out any potential cancer.

References

[1] Context 10: The diagnosis of adenofibroma typically involves a combination of imaging studies, such as ultrasound or magnetic resonance imaging (MRI) scan, and a histopathological biopsy to confirm the presence of the tumor.

[2] Context 3: While imaging tests may suggest a fibroadenoma, the conclusive diagnostic test is usually a breast biopsy, a procedure to remove a sample of tissue for examination in a lab.

[3] Context 10: Preoperative laboratory tests and tumor markers were performed. The results of cancer antigen (CA) 125, CA 19-9, and alpha-fetoprotein, may be performed to rule out any potential cancer.

Based on the provided context, it appears that adenofibroma is a rare benign tumor that can occur in various parts of the body, including the uterus and endocervix.

Unfortunately, there is limited information available on the drug treatment of adenofibroma. However, I was able to find some relevant information from search results:

• According to search result [10], hysterectomy (surgical removal of the uterus) is considered a preferred treatment for endometrial adenofibroma, which suggests that surgical intervention may be necessary in some cases.
• Search result [14] mentions that MRI was performed and showed a solid, homogenous mass, with moderate enhancement occupying the entire breast. However, it does not provide information on drug treatment.

It's worth noting that adenofibroma is an extremely uncommon condition, and as such, there may be limited research or data available on its treatment.

However, based on the provided context, it seems that surgical intervention (such as hysterectomy) may be a common approach to treating adenofibroma. Unfortunately, I was unable to find any information on drug treatments specifically for adenofibroma.

If you're looking for more information on this topic, I would recommend searching for peer-reviewed articles or consulting with a medical professional who specializes in gynecology or oncology.

References: [10] [14]

The differential diagnosis of adenofibroma involves distinguishing it from other tumors that may have similar characteristics. According to various sources, the main differential diagnoses for adenofibroma include:

• Adenosarcoma: This is a malignant tumor that can be distinguished from adenofibroma by the presence of a stromal mitotic count of 2 or more per 10 HPFs [12][14].
• Carcinosarcoma: This is a rare and aggressive type of cancer that can be confused with adenofibroma due to its biphasic growth pattern [6][14].
• Adenomyomas: These are benign tumors that consist of glandular epithelium surrounded by smooth muscle cells, which can be similar to adenofibroma in appearance [6].
• Benign endometrial polyps: These are small, non-cancerous growths on the lining of the uterus that can be confused with adenofibroma due to their similar histological features [6].

It's worth noting that the diagnosis of adenofibroma is often straightforward, but some malignant tumors may enter into the differential diagnosis due to their biphasic growth pattern [5]. A thorough examination and histopathological analysis are usually required to confirm the diagnosis.

References:

• [1] M Ajmal (2022) - Differential Diagnosis
• [6] S Moradan (2019) - The differential diagnoses are adenosarcoma, adenomyomas, carcinosarcoma (1), and benign endometrial polyps (6).
• [12] by R Maciel (2013) - Adenofibroma must be differentiated from endometrial polyp, hyperplasia, and carcinoma.
• [14] The differential diagnosis of uterine müllerian adenosarcoma includes the following: (1) so-called uterine adenofibroma, or atypical uterine polyp; (2) carcinosarcoma ...