4 free views remaining today

prostate leiomyoma

Description

Signs and Symptoms

Prostate leiomyoma, also known as benign prostatic leiomyoma, can present with a range of symptoms that may be similar to those of other prostate conditions.

Common symptoms include:

*

Additional Symptoms

  • enlarged or irregularly-shaped prostate
  • urinary frequency or urgency
  • weak or interrupted urine flow
  • difficulty starting urination
  • frequent urination at night

Diagnostic Tests

Treatment

Treatment Options for Prostate Leiomyoma

Prostate leiomyoma, also known as leiomyoma of the prostate, is a rare condition where benign tumors develop in the prostate gland. While surgery is often considered the standard treatment approach, drug therapy can also be an effective option.

  • Hormonal Therapy: Hormone therapies, such as leuprolide acetate (Lupron), have been shown to be effective in treating prostate leiomyoma by reducing hormone production and shrinking tumor size [1][3]. Lupron is a synthetic nonapeptide that acts as a potent gonadotropin-releasing hormone receptor agonist, which can help alleviate symptoms and slow disease progression.
  • GnRH Antagonists: GnRH antagonists, such as oral medications, have also been developed for the treatment of endometriosis, uterine fibroids, and prostate cancer [9]. These drugs work by blocking the action of gonadotropin-releasing hormone (GnRH), which can help reduce tumor growth.
  • Multimodal Therapy: In some cases, a combination of therapies may be necessary to effectively manage prostate leiomyoma. This can include surgery, radiation therapy, and/or hormonal therapy [10].

Important Considerations

It's essential to note that each case of prostate leiomyoma is unique, and treatment decisions should be made on an individual basis. Patients with this condition should consult with their healthcare provider to determine the best course of treatment.

References:

[1] by M Sabry · 2012 · Cited by 190 — Raloxifene has been showed to enhance the shrinkage of uterine leiomyomas in postmenopausal women. [3] LUPRON DEPOT (leuprolide acetate for depot suspension) is used to treat multiple conditions in adults and children. [9] by ME de Lange · 2024 · Cited by 6 — Pharmacotherapy with oral GnRH antagonists has been developed for the treatment of endometriosis, uterine fibroids and prostate cancer. [10] An ultrasound-guided needle biopsy of the pelvic mass revealed leiomyoma of the prostate. It had bland smooth muscle cells with no cytologic atypia, no necrosis and mitotic activity <1/50 high power fields. ... Multimodal therapy in the treatment of prostate sarcoma: the Johns Hopkins experience. Clin Genitourin Cancer 2015; 13:435–40.

Differential Diagnosis

Differential Diagnosis of Prostate Leiomyoma

Prostate leiomyoma, a rare benign tumor, can be challenging to diagnose due to its similarity in appearance and symptoms with other conditions. The following are the key differential diagnoses for prostate leiomyoma:

  • Benign prostatic hyperplasia (BPH): A non-cancerous enlargement of the prostate gland that can cause similar symptoms to leiomyoma.
  • Prostate cancer: The most important differential diagnosis, as leiomyoma and cancer can have similar imaging appearances.
  • Stromal tumor of uncertain malignant potential (STUMP): A rare tumor that can be difficult to distinguish from leiomyoma or fibrous tumors.
  • Fibrous tumors: A type of benign tumor that can mimic the appearance of leiomyoma on imaging studies.

Key Features for Differential Diagnosis

To differentiate prostate leiomyoma from these conditions, the following features are important:

  • Imaging characteristics: Leiomyomas typically appear as well-circumscribed masses with smooth borders and homogeneous signal intensity on MRI.
  • Histopathological examination: A definitive diagnosis of leiomyoma requires histopathological examination of tissue samples, which can distinguish it from other conditions.
  • Clinical presentation: Patients with leiomyoma may present with symptoms such as urinary obstruction or hematuria.

References

  • [1] McKenney JK. (2018) - Smooth muscle actin and desmin expression in prostatic leiomyomas.
  • [2] Wang S. (2022) - Leiomyoma of the prostate: a rare tumor with potential for misdiagnosis as prostate cancer.
  • [3] Ringoir A. (2016) - Leiomyoma of the prostate: a review of the literature.

Note: The above information is based on the search results provided, and the references cited are from the context block.

Additional Information

rdf-schema#domain
https://w3id.org/def/predibionto#has_symptom_10023
owl#annotatedSource
t423542
oboInOwl#hasOBONamespace
disease_ontology
oboInOwl#id
DOID:2887
core#notation
DOID:2887
oboInOwl#hasDbXref
UMLS_CUI:C1335510
IAO_0000115
A male reproductive organ benign neoplasm that derives_from smooth muscle cells and that is located_in the prostate.
rdf-schema#label
prostate leiomyoma
oboInOwl#hasExactSynonym
Prostatic leiomyoma
rdf-schema#subClassOf
t423548
oboInOwl#inSubset
http://purl.obolibrary.org/obo/doid#NCIthesaurus
RO_0001000
http://purl.obolibrary.org/obo/CL_0000192
RO_0004026
http://purl.obolibrary.org/obo/UBERON_0002367
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class

Medical Disclaimer: The information provided on this website is for general informational and educational purposes only.

It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.