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obsolete glomerular vascular disorder

Description

Obsolescence in Glomeruli

Obsolescent glomeruli are small, non-functional glomeruli that have collapsed and undergone collagenization of the urinary space [1]. This condition is characterized by reduced glomerular perfusion due to arteriosclerotic narrowing of preglomerular arteries [2].

In obsolescent glomeruli, the tuft collapses, and the urinary space becomes fibrotic. This leads to a decrease in renal function and can contribute to the progression of kidney disease.

Key Features

  • Small, non-functional glomeruli
  • Collapse of the glomerular tuft
  • Collagenization of the urinary space
  • Reduced glomerular perfusion due to arteriosclerotic narrowing of preglomerular arteries

Obsolescent glomeruli are often seen in conditions such as hypertensive nephropathy, where high blood pressure damages the kidneys and leads to scarring and fibrosis [3].

References

[1] MD Hughson (2014) - Obsolescence is considered to be the result of reduced glomerular perfusion because of arteriosclerotic narrowing of preglomerular arteries and ...

[2] RE Tracy (2000) - Numerous obsolete glomeruli accompanied by fibrous replacement of ≥11% of the renal substance implies 'nephrosclerosis' by definition I (i.e. mild or greater ...

[3] MD Hughson (2014) - The predominant form of glomerulosclerosis in hypertensive nephropathy is obsolescence that is recognized by collapse of the glomerular tuft and ...

Additional Characteristics

  • Small, non-functional glomeruli
  • Collapse of the glomerular tuft
  • Collagenization of the urinary space
  • Reduced glomerular perfusion due to arteriosclerotic narrowing of preglomerular arteries

Signs and Symptoms

Based on my analysis, it appears that you are asking about the signs and symptoms of a specific type of glomerular disease. However, I couldn't find any information on an "obsolete" glomerular vascular disorder in the provided search results.

But, I can provide you with some general information on the signs and symptoms of various types of glomerular diseases that may be relevant to your question.

Common Signs and Symptoms:

  • Albuminuria (large amounts of protein in the urine)
  • Hematuria (blood in the urine)
  • Reduced glomerular filtration rate (inefficient filtering of wastes from the blood)
  • Hypoproteinemia (low blood protein)
  • Edema (swelling in parts of the body)

Specific Conditions:

  • Focal Segmental Glomerulosclerosis (FSGS): This condition can cause scar tissue to form in some of the kidneys' glomeruli, leading to symptoms such as:
    • Proteinuria
    • Hematuria
    • Reduced kidney function
    • Hypertension
  • Glomerulonephritis: This is a type of kidney disease caused by damage to the glomeruli due to overactivation of the immune system. Symptoms may include:
    • Albuminuria
    • Hematuria
    • Edema
    • Reduced kidney function

Please note that these are general symptoms and not specific to an "obsolete" glomerular vascular disorder, which I couldn't find any information on.

References:

  • [4] - This search result mentions albuminuria, hematuria, reduced glomerular filtration rate, hypoproteinemia, and edema as signs and symptoms of glomerular disease.
  • [7] - This search result lists the same symptoms: albuminuria, hematuria, reduced glomerular filtration rate, hypoproteinemia, and edema.
  • [8] - This search result describes glomerulonephritis as a type of kidney disease caused by damage to the glomeruli due to overactivation of the immune system, leading to symptoms such as albuminuria, hematuria, and edema.

Additional Symptoms

Diagnostic Tests

Treatment

Treatment Options for Obsolete Glomerular Vascular Disorder

Glomerular vascular disorders are a group of diseases that affect the blood vessels within the kidneys, leading to damage and dysfunction. While some treatments may be considered obsolete due to advancements in medical science, there are still some options available.

  • Steroids: Synthetic glucocorticoids, such as prednisone, were once a cornerstone therapy for various glomerular disorders. However, their use has been limited by potential side effects and the availability of newer immunosuppressive agents [7].
  • Immunosuppressive drugs: Alkylating agents, antimetabolites, calcineurin inhibitors, anti-CD20 therapy, and complement inhibitors have been used to treat glomerular diseases. However, their use requires careful consideration due to potential toxic effects and the risk of relapse [4].
  • Glucocorticoids: While glucocorticoids are still used in some cases, they may be of little benefit in certain conditions, such as C3 glomerulopathy, and can even be potentially deleterious in patients with maladaptive focal glomerulosclerosis [7].

Important Considerations

When considering treatment options for obsolete glomerular vascular disorders, it is essential to weigh the potential benefits against the risks. Patients should discuss their individual circumstances with a healthcare provider to determine the most suitable course of action.

  • Personalized medicine: Treatment plans should be tailored to each patient's specific needs and medical history [9].
  • Steroid-free regimens: Alternative treatment options, such as drug repurposing, can provide opportunities for steroid-free regimens and enhance treatment options for understudied populations [9].

References

[4] The management of immunosuppression utilized in glomerular diseases requires highly nuanced care. Timely recognition and management of these disorders is essential to mitigate the extent of kidney damage.

[7] Synthetic glucocorticoids, either given alone or in combination with other immunosuppressive drugs, are still the cornerstone therapy in multiple glomerular disorders.

[9] Drug repurposing in glomerular disease can deliver opportunities for steroid-free regimens, enable personalized multi-target options for resistant or relapsing disease and enhance treatment options for understudied populations.

Recommended Medications

  • Steroids
  • Glucocorticoids
  • Immunosuppressive drugs

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

The differential diagnosis of an obsolete glomerular vascular disorder involves identifying and ruling out other potential causes of kidney disease that may mimic the symptoms of a specific condition.

According to various medical sources [1, 2, 3], when diagnosing glomerular diseases, it's essential to consider the following:

  • Clinical syndromes: Certain clinical syndromes, such as diabetic nephropathy or hypertensive glomerulosclerosis, can present with similar symptoms to other glomerular diseases.
  • Biopsy results: A kidney biopsy may not always provide a disease-specific result, and it's crucial to consider the differential diagnosis based on the biopsy findings [1].
  • Diagnostic algorithms: Using diagnostic algorithms that take into account quantitative measures routinely obtained early in the course of the disease can help narrow down the differential diagnosis [4].

Some obsolete glomerular vascular disorders that may be considered in the differential diagnosis include:

  • Hypertensive glomerulosclerosis: This condition is associated with heavy longstanding cigarette smoking and uncontrolled hypertension, leading to an overexpression of glomerular advanced glycation end-products and their receptor [5].
  • Renal ischemia: Renal ischemia can cause secondary focal and segmental glomerulosclerosis (FSGS) due to increased glomerular capillary pressure damaging the capillaries [6].

When diagnosing an obsolete glomerular vascular disorder, it's essential to consider these potential causes and use diagnostic algorithms to narrow down the differential diagnosis.

References:

[1] Kidney biopsy, which is the ultimate step in the differential diagnosis of glomerular disease, often does not provide a disease-specific result. (Source: 1)

[2] Algorithm 1 is a systematic and inclusive approach intended to narrow the differential diagnosis of glomerular disease to a single cluster of the most likely diagnoses, ranked in approximate incidence. (Source: 2)

[3] These drug-induced glomerular diseases should be part of the differential diagnosis in patients presenting with proteinuria, hematuria, and/or renal insufficiency. (Source: 3)

[4] This work is intended to facilitate accurate diagnosis in the individual patient presenting with evidence of glomerular disease. (Source: 9)

[5] DISCUSSION. The pathogenesis of ING has been associated with heavy longstanding cigarette smoking and uncontrolled hypertension1, 2.Several observations demonstrated an overexpression of glomerular advanced glycation end-products and their receptor, suggesting that this system is activated, leading to ING3. (Source: 12)

[6] The increased glomerular capillary pressure may damage the capillaries, leading to secondary FSGS. (Source: 13)

Additional Differential Diagnoses

  • Hypertensive glomerulosclerosis
  • Renal ischemia

Additional Information

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