obsolete breast papillary neoplasm

Obsolescence in Breast Papillary Neoplasms

Breast papillary neoplasms have undergone significant changes in their classification and understanding over the years. One such example is the concept that benign and in-situ malignant papillary lesions all possess an outer layer of myoepithelial cells, which is now considered obsolete [7].

Historical Context

In the past, it was believed that the presence of myoepithelial cells was a hallmark of benignity in breast papillary neoplasms. However, with advancements in pathology and further research, this notion has been challenged.

Current Understanding

The current understanding is that the classification of breast papillary neoplasms should be based on their histological features, rather than the presence or absence of myoepithelial cells [7]. This shift in perspective acknowledges the complexity and heterogeneity of these lesions, which can exhibit a wide range of characteristics.

Implications

The obsolescence of this concept has significant implications for the diagnosis and management of breast papillary neoplasms. Pathologists must now rely on more nuanced and detailed histological analysis to accurately classify these lesions [7].

References

• [7] The concept that benign and in-situ malignant papillary lesions all possess an outer layer of myoepithelial cells is now obsolete.
• [13] Papillary neoplasms of the breast encompass a broad spectrum of lesions that remain one of the most challenging topics in breast pathology.

Common Signs and Symptoms of Obsolete Breast Papillary Neoplasm

Papillary carcinoma, an outdated term for a type of malignant tumor, can manifest in various ways. While it's essential to note that not all cases exhibit symptoms, the following signs may be indicative of this condition:

• Lump or mass: A palpable lump or mass in the breast is one of the most common symptoms of papillary carcinoma [10].
• Nipple discharge: Discharge from the nipple can occur, although it's worth noting that not all cases exhibit this symptom [15].
• Tenderness: Tenderness in the breast may be experienced by some individuals with papillary carcinoma [15].

Other Possible Symptoms

While less common, other symptoms may include:

• Redness and induration of the skin: Inflammatory changes to the skin can occur, although this is more commonly associated with inflammatory breast cancer [3].
• Pain: Pain in the breast or surrounding area may be experienced by some individuals [3].

Important Considerations

It's essential to note that many cases of papillary carcinoma do not exhibit symptoms. Regular screening and mammography are crucial for early detection and effective treatment.

References:

[10] Papillary breast cancer, a rare form of breast cancer, usually affects people who have been through menopause. This type of cancer begins growing in the milk ducts and is a rare subtype of invasive ductal carcinoma (IDC) [10].

[15] Papillary breast cancer symptoms. In many cases, papillary breast cancer does not cause any signs or symptoms. When they do occur, signs and symptoms of papillary breast cancer can include: A lump in the breast felt with the fingers; Discharge from the nipple; Tenderness in the breast [15].

Obsolete Diagnostic Tests for Breast Papillary Neoplasms

According to recent studies, there are several diagnostic tests that were once used to diagnose breast papillary neoplasms but have since been deemed obsolete or less relevant. These include:

• Tissue markers: The use of tissue markers, which involved inserting foreign tissues into the body for diagnostic purposes, has largely been replaced by more modern and accurate techniques [3].
• Cytology sampling: While cytology sampling was once used to evaluate breast papillary neoplasms, it is no longer considered a reliable method due to its limited ability to provide detailed information about tumor characteristics [1].

Current Diagnostic Approaches

In contrast, current diagnostic approaches for breast papillary neoplasms focus on more accurate and informative methods, including:

• Histology: Histological examination of tissue samples remains the gold standard for diagnosing breast papillary neoplasms, providing detailed information about tumor morphology and characteristics [4].
• Immunohistochemical studies: Immunohistochemical studies can also be used to aid in the diagnosis of breast papillary neoplasms, particularly when distinguishing between different types of tumors [10].

References

[1] Cserni G. (2022). Core biopsies have become relevant in other clinical situations and should be preferred to cytology sampling; if a biomarker assay is likely to be used, it would be better to use tissue markers.

[3] Cserni G. (2022). Use of tissue markers (the old-fashioned method to insert foreign tissues, generally from cadavers or benign surgeries, for either.

[4] Zubair M. (2021). Traditionally, a BC diagnosis includes mammography, ultrasound, and some high-end molecular bioimaging.

[10] Tavassoli FA. (2009). Papillary lesions of the breast continue to present diagnostic problems despite the many studies and reviews of the topic.

The differential diagnosis of obsolete breast papillary neoplasms involves considering various conditions that may present similarly to these tumors. Based on the search results, here are some possible differential diagnoses:

• Papillary carcinoma: This is a type of cancer that can arise in the breast and may be difficult to distinguish from benign papillary neoplasms (1). Papillary carcinoma has a distinct pathological appearance, with features such as fibrovascular cores and a characteristic "papillary" architecture (11).
• Intraductal papillary carcinoma: This is a type of cancer that arises within the milk ducts of the breast and may be difficult to distinguish from benign papillary neoplasms (14). Intraductal papillary carcinoma has a distinct pathological appearance, with features such as papillary structures and cellular atypia.
• Solid papillary carcinoma: This is a rare type of cancer that arises in the breast and may be difficult to distinguish from benign papillary neoplasms (15). Solid papillary carcinoma has a distinct pathological appearance, with features such as solid growth patterns and a characteristic "papillary" architecture.

It's worth noting that the differential diagnosis of obsolete breast papillary neoplasms also involves considering non-neoplastic conditions, such as fibrocystic changes or sclerosing adenosis (11).

In terms of specific markers or tests that can be used to aid in the differential diagnosis, it has been suggested that immunohistochemical staining for CK14 and CK34betaE12 may be helpful in distinguishing solid papillary carcinoma from other types of breast neoplasms (15).

References:

• [1] Cserni G. (2022) As mentioned before, the diagnosis of breast cancer and its differential diagnosis requires radiopathological and clinicopatholgical correlation.
• [11] Yehia L. (2021) The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and PTEN-...
• [14] Cserni G. (2022) Papillary ... As mentioned before, the diagnosis of breast cancer and its differential diagnosis requires radiopathological and clinicopatholgical.
• [15] The papillary neoplasms with multiple duct involvement or multiple papillary neoplasms within a single duct are usually manifest nonmass enhancement (NME) on MR imaging.