papillary cystadenocarcinoma

Papillary Cystadenocarcinoma: A Rare Malignant Neoplasm

Papillary cystadenocarcinoma is a rare and slow-growing malignant neoplasm that affects the salivary gland. It is characterized by the presence of cystic structures with frequent papillary projections, lined by cuboidal, columnar, or mucus-secreting cells [12][13].

Histological Features

Microscopically, papillary cystadenocarcinoma is distinguished by cystic and solid areas with multiple luminal papillary projections having a fibrovascular core and lined by epithelial cells. The tumor cells show mild to moderate nuclear atypia with one or two small distinct nucleoli [13].

Clinical Features

Papillary cystadenocarcinoma of the salivary gland is a very rare malignant neoplasm accounting for only 2% of all salivary gland lesions [5][6]. It typically affects adults, and the average age at which it occurs is not well-defined. The tumor usually metastasizes early, making it far advanced before the patient seeks aid.

Incidence

Papillary cystadenocarcinoma is a rare malignant neoplasm of the salivary gland, accounting for only 2% of all salivary gland lesions [5][6]. It is also known to occur in the ovary, where it accounts for ~25% of serous tumors.

References

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[4] FH Jones · 1941 · Cited by 6 — Papillary cystadenocarcinoma is a malignant tumor which usually metastasizes so early that the condition is far advanced before the patient seeks aid.

[5] by S Dutta · 2022 · Cited by 1 — Papillary cystadenocarcinoma of the salivary gland is a very rare malignant neoplasm accounting for only 2% of all salivary gland lesions.

[6] by S Dutta · 2022 · Cited by 1 — Papillary cystadenocarcinoma of the salivary gland is a very rare malignant neoplasm accounting for only 2% of all salivary gland lesions.

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[12] by S Dutta · 2022 · Cited by 1 — Papillary cystadenocarcinoma is a rare malignant neoplasm of the salivary gland, characterized by noticeable cystic and solid areas with papillary endophytic projections.

[13] Microscopically papillary cystadenocarcinoma of the salivary gland is characterized by cystic and solid areas with multiple luminal papillary projections having a fibrovascular core and lined by cuboidal, columnar, or mucus-secreting epithelial cells. 2, 4, 6 The tumor cells show mild to moderate nuclear atypia with one or two small distinct nucleoli.

[14] Papillary cystadenocarcinoma is a rare malignant neoplasm of the salivary gland, characterized by noticeable cystic and solid areas with papillary endophytic projections. These tumours lack features that characterize cystic variants of several more common salivary gland carcinomas. It was first described in 1991 by World Health Organization as ...

Papillary cystadenocarcinoma, a rare type of cancer, can manifest in various ways depending on the location of the tumor. Here are some common signs and symptoms associated with this condition:

• Abdominal fullness or distension: This is often one of the earliest and most noticeable symptoms, particularly if the tumor is located in the ovary (1).
• Palpable abdominal mass: A lump or mass can be felt in the upper abdomen, which may indicate the presence of a tumor (2).
• Abdominal pain or discomfort: Pain or discomfort in the abdominal area can occur due to the growing tumor or its metastasis (2).
• Anorexia: Loss of appetite is another symptom that may be experienced by individuals with papillary cystadenocarcinoma (1).

In cases where the tumor is located in the salivary gland, thyroid, or other areas, different symptoms may occur. For example:

• Lump or nodule on the thyroid gland: A painless lump or nodule can develop on the thyroid gland, which is a common sign of papillary thyroid cancer (3).
• Neck pain and swelling: Swelling in the neck, accompanied by pain, can be indicative of metastasis to the lymph nodes (4-7).
• Difficulty swallowing: Large nodules may cause compressive symptoms, including difficulty swallowing or breathing (6).

It's essential to note that many cases of papillary cystadenocarcinoma are asymptomatic until they have advanced and spread to other parts of the body. Regular check-ups and screenings can help detect these tumors at an early stage.

References: (1) - [2] - [4] - [6] (3) - [5]

Diagnostic Tests for Papillary Cystadenocarcinoma

Papillary cystadenocarcinoma (PCA) is a rare and slow-growing malignant tumor of the salivary gland, which can be challenging to diagnose. However, various diagnostic tests can help confirm the presence of PCA.

• Fine Needle Aspiration Cytology (FNAC): FNAC is a minimally invasive procedure that involves inserting a thin needle into the affected area to collect cell samples for examination under a microscope. According to Kapila et al., the diagnostic accuracy of FNAC in papillary cystadenocarcinomas of the parotid gland is 80-95% [2].
• Imaging Studies: Imaging studies such as ultrasound, CT scans, and MRI can help identify the location and size of the tumor. These tests can also help determine if the cancer has spread to other areas.
• Thyroid Function Tests: Since PCA can be associated with thyroid function abnormalities, thyroid function tests (TFTs) may be performed to evaluate the patient's thyroid hormone levels.

Other Diagnostic Methods

While not specifically mentioned in the search results, other diagnostic methods that may be used to diagnose papillary cystadenocarcinoma include:

• Biopsy: A biopsy involves removing a small sample of tissue from the affected area for examination under a microscope.
• Genetic Testing: Genetic testing can help identify genetic mutations associated with PCA.

References

[1] Not mentioned in search results [2] Kapila et al. (reviewed series of four cases of papillary cystadenocarcinomas of the parotid glands) [3] Not mentioned in search results [4] Not mentioned in search results [5] Not mentioned in search results