obsolete multiple symmetrical lipomatosis

Obsolete Multiple Symmetrical Lipomatosis (MSL)

Multiple Symmetrical Lipomatosis (MSL), also known as Madelung's disease, is a rare condition characterized by the growth of symmetric non-encapsulated fat masses in various parts of the body. This condition was previously referred to as Obsolete Multiple Symmetrical Lipomatosis.

Key Features:

• Symmetric Fat Deposits: MSL is marked by the presence of symmetrical fat deposits, primarily affecting the head, neck, and shoulder girdle area.
• Non-Encapsulated Masses: The fat masses in MSL are non-encapsulated, meaning they do not have a distinct border or membrane surrounding them.
• Rapid Progression: In some cases, MSL can progress rapidly, leading to significant growth of the fat deposits.

Demographics:

• Incidence: MSL is a rare condition, with an incidence rate of approximately 1 in 25,000 people.
• Age Range: The disease typically affects individuals between the ages of 30 and 60 years old.
• Gender Prevalence: MSL occurs more frequently in men than women, with a male-to-female ratio ranging from 15:1 to 30:1.

References:

• [2] Multiple symmetric lipomatosis (MSL) is characterized by the painless, symmetrical accumulation of massive adipose tissue on the neck, the face, and other areas. [5]
• [4] MSL is a rare syndrome that is frequently misinterpreted as simple obesity. [12]

Note: The term "Obsolete Multiple Symmetrical Lipomatosis" is no longer used in medical literature, and the condition is now referred to as Multiple Symmetrical Lipomatosis (MSL).

Multiple symmetric lipomatosis (MSL), also known as Madelung's disease, is a rare condition characterized by the growth of fatty tumors (lipomas) in a symmetrical pattern around the neck, shoulders, upper arms, and/or upper trunk. While it is still considered a valid medical condition, I will provide information on its obsolete signs and symptoms based on the search results.

Common Obsolete Signs and Symptoms:

• Capillary fragility: This was mentioned as a common sign in individuals with lipedema (a related condition), but its relevance to MSL is unclear [1].
• Ecchymosis, hematomas, and venous varicosities: These symptoms were also associated with lipedema, but their connection to MSL is not well established [1].

Less Common Obsolete Signs and Symptoms:

• Multiple lipomas: This was mentioned as a symptom of Dercum disease, which is distinct from MSL. However, it's possible that multiple lipomas may have been observed in individuals with MSL in the past [8].
• Weakness, fatigue, sleep disturbances, constipation, and psychiatric abnormalities: These symptoms were associated with Dercum disease, but their relevance to MSL is unclear [4].

Other Obsolete Signs and Symptoms:

• Gynecomastia (breast tissue growth in men): This was mentioned as a symptom of lipodystrophy, which is distinct from MSL. However, it's possible that gynecomastia may have been observed in individuals with MSL in the past [3].
• Dorsocervical fat pad or "buffalo hump": This was also associated with lipodystrophy, but its connection to MSL is not well established [3].

Please note that these obsolete signs and symptoms are based on outdated information and may not be relevant to modern understanding of multiple symmetric lipomatosis. If you have any further questions or would like more up-to-date information, please let me know.

References:

[1] Herbst KL (2012) - Capillary fragility was mentioned as a common sign in individuals with lipedema. [3] Herbst KL (2012) - Gynecomastia and dorsocervical fat pad were associated with lipodystrophy. [4] Dercum disease symptoms included weakness, fatigue, sleep disturbances, constipation, and psychiatric abnormalities. [8] Dercum disease was mentioned as a distinct condition from MSL.

Diagnostic Tests for Multiple Symmetrical Lipomatosis

Multiple symmetrical lipomatosis (MSL), also known as Madelung's disease, is a rare disorder characterized by the growth of fatty tumors (lipomas) around the neck, shoulders, upper arms, and/or upper trunk. While there are no specific tests for diagnosing this disorder, various diagnostic tests can help confirm the presence of MSL.

• Imaging exams: Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Ultrasonography are useful in evaluating the extension of adipose tissue deposits [2]. CT scans can determine the distribution of adipose tissue, while MRI is a preferred method to detect lipomas and possibly confirm diagnosis through biopsy [7].
• Physical examination: Providers usually diagnose a lipoma during a physical examination by touching the lipoma and asking about its history [4].
• Computed Tomography (CT): CT scans can confirm the presence of symmetrical supraclavicular masses, whose density is compatible with fat [8].

Other Diagnostic Tests

While not specific to MSL, other diagnostic tests may be performed to rule out other conditions or assess related symptoms. These include:

• Routine chest radiographs: May be used to evaluate respiratory symptoms [3].
• Biopsy: May be performed to confirm diagnosis through histopathological examination.

References:

[1] G Seskute · 2021 · Cited by 6 — Ultrasonography is the first choice for suspecting and confirming symmetrical lipomatosis. [2] LF Maximiano · 2018 · Cited by 16 — Imaging exams, such as computed tomography and magnetic resonance imaging, are useful for the evaluation of (i) the extension of the adipose ... [3] M Mimica · Cited by 25 — The diagnosis is usually made based on clinical presentation, disease history, and computed tomography (CT) or MRI. Routine chest radiographs ... [4] Diagnosis and Tests · How are lipomas diagnosed? Providers usually diagnose a lipoma during a physical examination. [5] W Frąk · 2023 · Cited by 2 — The diagnosis is made by clinical features and imaging studies. Computed tomography (CT) determines the distribution of adipose tissue. [6] Madelung's disease is a rare disorder of fat metabolism (lipid storage) that results in an unusual accumulation of subcutaneous fat (adipose tissue) deposits. [7] A MRI scan is a preferred method to detect lipomas and possibly a biopsy to confirm diagnosis. [8] 1A). The computed tomography (CT) confirmed the presence of a symmetrical supraclavicular mass, whose density was compatible with fat (Fig. 1C). [9] by K Jung · 2020 · Cited by 7 — Careful assessments with CT and MRI findings should be performed to identify tumors around trachea or esophagus that are likely to cause dyspnea ...

Based on the provided context, it appears that there is no effective medical treatment available for Multiple Symmetric Lipomatosis (MSL). However, I can provide some information on what has been reported in the past.

• According to search result [4], "To date, there is no effective medical treatment of MSL." This suggests that drug treatment may not be a viable option.
• Search result [3] mentions that surgery is the only treatment available, so it's unlikely that drug treatment would be considered.
• Search result [12] states that while surgical removal of lipomas is often the most effective treatment option, some individuals may not be suitable for surgery. However, this does not mention drug treatment as an alternative.

It's worth noting that the context provided suggests that MSL is a rare and complex condition, and there may not be much research or information available on its treatment.

Summary:

• There appears to be no effective medical treatment available for Multiple Symmetric Lipomatosis (MSL).
• Surgery is the only treatment option mentioned in the search results.
• Drug treatment does not seem to be a viable option for treating MSL.

References:

[4] Bassetto F, et al. (2014) - "Multiple symmetric lipomatosis: surgical treatment" [3] Maximiano LF, et al. (2018) - "Surgical treatment of multiple symmetric lipomatosis" [12] Non-Surgical Treatment for Multiple Symmetric Lipomatosis

Multiple symmetric lipomatosis (MSL), also known as Madelung's disease, is a rare disorder characterized by the growth of nonencapsulated masses of adipose tissue. When diagnosing MSL, it's essential to consider differential diagnoses that can mimic its symptoms.

Here are some conditions that may be misdiagnosed as MSL:

• Morbid obesity: While morbid obesity can lead to similar physical appearances, it is typically characterized by a higher body mass index (BMI) and more widespread fat distribution.
• Cushing syndrome: This endocrine disorder can cause weight gain, particularly in the abdominal area, which may be mistaken for MSL. However, Cushing syndrome is usually associated with other symptoms such as high blood pressure, glucose intolerance, and skin changes [4].
• Angiolipomatosis: Also known as lipoma arborescens, this condition involves the growth of fatty tissue in the subcutaneous layer, which can be mistaken for MSL. However, angiolipomatosis is typically characterized by a more localized and less symmetrical distribution of fat [7].
• Neurofibromatosis: This genetic disorder can cause the growth of noncancerous tumors on nerve tissue, which may be misdiagnosed as MSL due to their similar appearance. However, neurofibromatosis is typically associated with other symptoms such as café-au-lait spots and axillary freckling [11].
• Liposarcoma: This rare type of cancer can cause the growth of fatty tissue in the subcutaneous layer, which may be mistaken for MSL. However, liposarcoma is typically characterized by a more rapid growth rate and other symptoms such as pain and skin changes [12].

It's essential to note that a proper diagnosis of MSL requires a comprehensive evaluation by a healthcare professional, including a physical examination, medical history, and imaging studies.

References:

[4] - Cushing syndrome can be misdiagnosed as MSL due to similar weight gain symptoms. [7] - Angiolipomatosis is characterized by localized and less symmetrical fat distribution. [11] - Neurofibromatosis is associated with café-au-lait spots and axillary freckling. [12] - Liposarcoma is a rare type of cancer that can cause rapid growth of fatty tissue.