bone angioendothelial sarcoma

Bone Angioendotheliomatosis: A Rare Vascular Disorder

Bone angioendotheliomatosis, also known as neoplastic angioendotheliomatosis, is a rare

Common Signs and Symptoms

Bone angioendothelioma, also known as epithelioid hemangioendothelioma (EHE), is a rare cancerous tumor that forms in cells lining your blood vessels. The signs and symptoms of EHE can vary depending on the location and severity of the tumor.

• Pain: Pain or discomfort in the affected area is one of the most common symptoms of bone angioendothelioma [1, 7].
• Swelling and Tenderness: Swelling and tenderness near the affected joint or bone can also occur [9, 10].
• Limited Joint Movement: In some cases, patients may experience limited movement in the affected joint due to pain or swelling [9].
• Bone Fractures: Pathologic fractures, where the bone breaks due to cancer, can occur in advanced stages of EHE [7].

Other Possible Symptoms

In addition to these common symptoms, other possible signs and symptoms of bone angioendothelioma may include:

• Fatigue
• Fever
• Weight loss
• Anemia (low red blood cell count)

It's essential to note that the severity and duration of these symptoms can vary greatly from person to person. If you're experiencing any unusual symptoms, it's crucial to consult with a healthcare professional for proper evaluation and diagnosis.

References:

[1] - Signs and symptoms They ... Endovascular papillary angioendothelioma, also known as "Dabska tumor", [2]

[7] by SFM Duncan · 2007 · Cited by 7 — Patients commonly present with nonspecific signs and symptoms, most commonly pain and swelling; few present with pathologic fractures [3].

[9] by R Volpe · 1982 · Cited by 75 — Eleven cases occurred in male, and seven in female patients (ratio 1.6:l). Signs and symptoms: Pain with limited joint move- ment was the ...

[10] Bone cancer most commonly affects the long bones in the arms and legs. Some types happen mostly in children, while others affect mostly adults. ... Symptoms. Signs and symptoms of bone cancer include: Bone pain. Swelling and tenderness near the affected area. Weakened bone, which can lead to a broken bone.

[11] Epithelioid hemangioendothelioma (EHE) is a rare cancerous tumor that forms in cells lining your blood vessels. Most tumors appear in your liver, lungs or bones. EHE varies in severity. Some tumors are aggressive while others grow slowly and never cause symptoms. Surgery, targeted therapy and watchful waiting are all potential treatments for EHE.

[15] Bone cancer symptoms vary from person to person. They also depend on the size and location of the cancer. If you have symptoms of bone cancer, they may include: Pain; Swelling or tenderness in or near a joint; Difficulty with normal movement; Fatigue; Fever; Weight loss; Anemia (low red blood cell count)

Diagnostic Tests for Bone Angioendotheliomatosis

Bone angioendotheliomatosis, also known as primary bone lymphoma (PBL), is a rare and challenging diagnosis to make. The diagnostic tests for this condition are crucial in confirming the presence of the disease.

• Imaging Studies: Magnetic Resonance Imaging (MRI) of the brain and spine can show multifocal areas of gray matter T2-weighted hyperintensity, which may not enhance with intravenous contrast [1]. Other imaging studies such as computed tomography (CT) scans and bone scintigraphy may also be used to evaluate the extent of disease.
• Biopsy: A biopsy of the affected bone is essential for a definitive diagnosis. The biopsy sample should be examined by a pathologist to confirm the presence of angiomatous tissue, absence of cellular atypia, and minimal or no osteoblastic response or dystrophic calcifications [5].
• Laboratory Tests: Complete blood count (CBC) and chemistry studies may be performed to evaluate the patient's overall health and detect any underlying conditions.
• Staging Workup: A staging workup should include routine magnetic resonance imaging of the CNS coupled with bone marrow biopsy, which plays a dual role in assessing the extent of disease [7].

References

[1] Schkeeper AE. Magnetic resonance imaging of the brain showed multifocal areas of gray matter T2-weighted hyperintensity.

[5] Diagnostic Exams ; chemistry studies ; marrow aspiration and biopsy ; scan ; Complete blood count (CBC) ; Laparoscopy (rarely performed).

[7] Staging workup of IVLBCL should therefore include routine magnetic resonance imaging of the CNS coupled with bone marrow biopsy, which plays the dual role of ...

Note: The above information is based on the search results provided and may not be an exhaustive list of diagnostic tests for bone angioendotheliomatosis.

The differential diagnosis for bone angioendothelioma (also known as Dabska tumor or papillary intralymphatic angioendothelioma) includes several vascular and non-vascular bone tumors. Some of the key conditions to consider in the differential diagnosis are:

• Eosinophilic granuloma: A type of Langerhans cell histiocytosis that can affect bones, particularly in children.
• Epithelioid hemangioendothelioma: A rare vascular tumor that can occur in soft tissues and bones.
• Clear cell chondrosarcoma: A type of cartilage cancer that can occur in bones, particularly in young adults.
• Osteoid osteoma: A benign bone tumor that is typically small and painful.
• Chondroblastoma: A rare, benign bone tumor that usually affects the ends of long bones.

These conditions should be considered in the differential diagnosis of bone angioendothelioma due to their similar clinical and radiological features. However, it's worth noting that the specific characteristics of each condition can help differentiate them from one another.

According to [13], broader differential diagnoses could include these conditions, which were proposed as radiological diagnoses for a case of PILA in bone.

Additionally, primary intraosseous PILAs are exceedingly rare tumors that should be considered in the differential diagnosis of vascular bone tumors, as mentioned in [15].

It's also worth noting that the clinical and histological features of angioendothelioma (Dabska tumor) of bone are discussed in [4], which may provide further insight into the differential diagnosis.

References:

[13] - Suggested broader differential diagnoses for PILA in bone. [15] - Mentioned primary intraosseous PILAs as exceedingly rare tumors that should be considered in the differential diagnosis of vascular bone tumors.