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invasive lobular carcinoma

Description

Invasive Lobular Carcinoma (ILC) Description

Invasive lobular carcinoma, also known as ILC, is a type of breast cancer that begins in the milk-producing glands of the breast [1]. It is the second most common form of breast cancer diagnosed in the United States, representing 10% to 15% of diagnosed cases [2].

ILC grows in the lobes of the breast, where milk is produced, and spreads outside these lobules into surrounding breast tissues [3][5]. This type of cancer is different from the more common invasive ductal carcinoma, which begins in the milk ducts [4].

Characteristics of ILC

  • ILC begins as a growth of cells in the milk-producing glands of the breast [1].
  • It spreads outside the lobules into surrounding breast tissues [3][5].
  • ILC is a rare type of breast cancer, making up 10% to 15% of diagnosed cases [2].

Symptoms of Metastatic Lobular Breast Cancer

In advanced stages, metastatic lobular breast cancer can cause symptoms such as: * Unexplained and persistent bone pain, especially in the back, ribs, or thighs [4]. * Unusual changes in the nipple, such as thickening or swelling [6].

Key Facts about ILC

  • ILC forms in the glands that produce milk [7].
  • It is a type of invasive breast cancer that begins in the lobules (milk glands) of the breast and spreads into surrounding normal tissue [8][9].

References: [1] Context 1 [2] Context 2 [3] Context 3 [4] Context 4 [5] Context 5 [6] Context 6 [7] Context 7 [8] Context 8 [9] Context 9

Additional Characteristics

  • Invasive lobular carcinoma, also known as ILC, is a type of breast cancer that begins in the milk-producing glands of the breast.
  • ILC grows in the lobes of the breast, where milk is produced, and spreads outside these lobules into surrounding breast tissues.
  • ILC begins as a growth of cells in the milk-producing glands of the breast.
  • It spreads outside the lobules into surrounding breast tissues.
  • ILC forms in the glands that produce milk.
  • It is a type of invasive breast cancer that begins in the lobules (milk glands) of the breast and spreads into surrounding normal tissue.

Signs and Symptoms

Common Signs and Symptoms of Invasive Lobular Carcinoma

Invasive lobular carcinoma (ILC) can cause a range of signs and symptoms, which may vary from person to person. Here are some common ones:

  • Hardened or thickened area inside the breast or underarm: This is one of the most common symptoms of ILC, as mentioned in [2] and [4].
  • Dimpling, dent, or puckering of the skin: The skin may appear to be dimpled or puckered, similar to an orange peel, as noted in [3] and [8].
  • Swelling of all or part of the breast: ILC can cause swelling or thickening of the breast tissue, which is a symptom mentioned in [4], [6], and [7].
  • Skin irritation: Some people may experience skin irritation, redness, or scaly patches on the breast, nipple, or areola, as noted in [8].
  • Changes in the texture of the breast skin: The skin may feel different to the touch, with some areas feeling thicker or more irregular than others, as mentioned in [3] and [4].

It's essential to note that ILC can cause no signs or symptoms at all, especially in its early stages. However, if you do experience any of these symptoms, it's crucial to consult a healthcare professional for proper evaluation and diagnosis.

References: [1] - Symptoms of invasive lobular carcinoma [2] - The most common invasive lobular carcinoma symptoms are: · Hardened or thickened area inside the breast or underarm · Dimpling, dent, or puckering ... [3] Symptoms of invasive lobular carcinoma · swelling of all or part of the breast · skin irritation · skin dimpling, sometimes looking like an orange peel · changes in ... [4] ILC Symptoms · An area of thickening, swelling or fullness in the breast · A nipple that turns inward · A change in the texture of the breast skin. [5] - Lobular breast cancer (also called invasive lobular carcinoma) is breast cancer that starts in the milk-producing gland, or lobules, of your breast and has ... [6] Jun 20, 2023 — Symptoms of invasive lobular breast cancer · an area of thickening or swelling · a change in the nipple, for example it might turn inwards (become ... [7] Jun 25, 2024 — Symptoms. At first, invasive lobular carcinoma may cause no signs and symptoms. As it grows larger, invasive lobular carcinoma may cause: A ... [8] Scaly, red, swollen, or unusually warm skin on the breast, nipple, or areola; Recent asymmetry (unequal or lack of sameness) of the breasts. It is important to ...

Additional Symptoms

  • Skin irritation
  • Dimpling, dent, or puckering of the skin
  • Hardened or thickened area inside the breast or underarm
  • Swelling of all or part of the breast
  • Changes in the texture of the breast skin

Diagnostic Tests

Invasive lobular carcinoma (ILC) can be challenging to detect, but various diagnostic tests are used to confirm its presence and gather more information about the cancer.

Diagnostic Imaging Tests

  • Diagnostic imaging tests such as mammograms, ultrasounds, and MRIs are commonly used to detect ILC. However, due to the nature of ILC tumors, they can be difficult to see on a mammogram [9].
  • Contrast Enhanced Spectral Mammography (CESM) is another diagnostic tool that can be used to detect ILC. CESM detects breast-enhancing lesions like MRI, though it is less time-consuming [7].

Lab Tests and Biopsy

  • After ILC is confirmed through imaging tests and a biopsy, lab tests are performed to collect more information about the cancer.
  • A biopsy involves taking a sample of tissue from the affected area for further examination.

Other Diagnostic Methods

  • MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature [6].

The diagnosis of ILC is often made through a combination of these tests, as well as a discussion of symptoms with a healthcare professional. It's essential to note that each individual's situation may vary, and not all diagnostic methods are suitable for everyone.

References: [1] - Not applicable (context provided) [6] by RM Mann · 2008 · Cited by 358 [7] by J Gerras [9] Oct 4, 2024

Additional Diagnostic Tests

  • Biopsy
  • Mammograms
  • Ultrasounds
  • MRIs
  • Contrast Enhanced Spectral Mammography (CESM)

Treatment

Treatment Options for Invasive Lobular Carcinoma (ILC)

Invasive lobular carcinoma, a type of breast cancer, can be treated with various drug therapies in addition to surgery and other treatments.

  • Targeted therapy: Targeted therapy uses drugs that are directed at specific proteins in cancerous cells. For ILC, targeted therapy often targets HER2 proteins [7]. This treatment approach has shown promise in treating ILC.
  • Chemotherapy: Chemotherapy involves using medications to kill cancer cells. Treatments for ILC may include chemotherapy as an adjuvant therapy, which is used in addition to surgery and other treatments [3].
  • Hormonal therapy: Hormonal therapy uses medications that block the effects of hormones on cancer cells. This treatment approach may be considered for ILC patients with hormone receptor-positive tumors.
  • Immunotherapy: Immunotherapy involves using medications that stimulate the immune system to attack cancer cells. Research is ongoing to explore the potential benefits of immunotherapy in treating ILC.

Additional Treatment Options

Other treatments for invasive lobular carcinoma include:

  • Radiation therapy: Radiation therapy uses high-energy rays to kill cancer cells [2].
  • Surgery: Surgery, including lumpectomy and mastectomy, may be used to remove cancerous tissue [5].

It's essential to note that treatment options for ILC are tailored to individual patients based on factors such as tumor size, stage, and hormone receptor status. A healthcare professional can provide personalized guidance on the most effective treatment plan.

References:

[1] - Not applicable (no relevant information in search results 1) [2] - Surgery is usually the first line of treatment recommended for invasive lobular carcinoma. · Radiation therapy. This treatment focuses high-energy ... [3] Adjuvant therapy (radiation and chemotherapy): In addition to surgery, your doctor may recommend treatments such as radiation or chemotherapy. Radiation ... [5] Treatment for invasive lobular carcinoma · Surgery: Surgical options include a lumpectomy (breast conserving surgery) or a mastectomy, which involves the partial ... [7] Targeted therapy to treat invasive lobular carcinoma uses drugs that are directed (targeted) at proteins in cancerous cells, most commonly HER2 proteins, ...

Recommended Medications

  • Chemotherapy
  • Immunotherapy
  • Targeted therapy
  • Hormonal therapy

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

Differential Diagnosis of Invasive Lobular Carcinoma

Invasive lobular carcinoma (ILC) is a type of breast cancer that originates in the milk-producing glands of the breast, known as lobules. The differential diagnosis of ILC involves identifying other conditions or cancers that may present with similar symptoms and characteristics.

Key Differential Diagnoses:

  • Invasive Ductal Carcinoma (IDC): This is the most common type of breast cancer, accounting for about 70-80% of all breast cancer cases. IDC starts in the milk ducts, which carry milk from the lobules to the nipple.
  • Mixed ILC and Mucinous Carcinoma: This rare type of cancer combines features of both ILC and mucinous carcinoma, a type of cancer that produces excess mucus.
  • Metaplastic Matrix-Producing Carcinoma (MMPC): This is a rare type of breast cancer that produces cartilage or bone-like tissue in addition to cancer cells.
  • Polymorphous Mammary Adenocarcinoma: This is a rare and aggressive type of breast cancer that can mimic other types of cancer.

Other Considerations:

  • Benign Breast Lumps and Cysts: These are non-cancerous growths or fluid-filled sacs in the breast that can cause similar symptoms to ILC.
  • Infection: Infections, such as mastitis, can cause inflammation and swelling in the breast, which may be mistaken for cancer.

Key Features:

  • Monotonous Round, Small, Discohesive Cells: ILC is characterized by cells that are small, round, and lack cohesion.
  • Extracellular Mucin Production: Some cases of ILC produce excess mucus, which can be a distinguishing feature.
  • Loss of E-cadherin and β-catenin Staining: This is a specific immunohistochemical marker that can help diagnose ILC.

References:

  1. [5] by H Haltas · 2012 · Cited by 31 — It is important for pathologists to recognize invasive lobular carcinoma with extracellular mucin because of the differential diagnosis.
  2. [6] by MK Ishikawa · 2015 · Cited by 12 — The most common entity in the differential diagnosis of ILC is invasive ductal carcinoma with lobular features (IDC-L), which typically has ...
  3. [9] by N Koufopoulos · 2022 · Cited by 4 — The differential diagnosis of ILC with papillary features includes solid papillary carcinoma (SPC), encapsulated papillary carcinoma (EPC), the solid or ...

Additional Differential Diagnoses

Additional Information

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