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obsolete breast hamartoma

Description

Signs and Symptoms

Breast Hamartoma Signs and Symptoms

Breast hamartomas, also known as fibroadenolipomas, are benign breast lesions that can cause a range of symptoms, although they are often asymptomatic. The signs and symptoms of breast hamartoma may include:

  • A round or oval well-defined lump: Breast hamartomas typically present as a single, distinct lump in the breast tissue.
  • Lump size variation: While small hamartomas may be barely noticeable, larger ones can grow to sizes exceeding 20 cm, causing cosmetic distortion of the breast shape.
  • No significant symptoms: Small hamartomas are often asymptomatic and only discovered accidentally on imaging studies for other reasons.

It's worth noting that breast hamartomas are generally not associated with any significant signs or symptoms, especially when they are small in size. However, if a lump grows very large, it can cause cosmetic distortion of the breast shape.

References:

  • [10] states that "About 5% of benign breast lumps are hamartomas."
  • [14] mentions that "The signs and symptoms of Hamartoma of Breast are generally not very significant, especially when it is small in size."
  • [15] estimates that breast hamartoma has an incidence rate between 0.1% and 0.7%, which is relatively rare.

Please note that these references are based on the provided context and may not be a comprehensive list of all possible signs and symptoms associated with breast hamartomas.

Additional Symptoms

  • A round or oval well-defined lump
  • Lump size variation

Diagnostic Tests

Diagnostic Tests for Breast Hamartoma

Breast hamartoma, an uncommon benign tumor, can be diagnosed using various imaging and diagnostic tests. While some tests may have been considered obsolete in the past, they are still relevant today.

  • Mammography: Although not always effective in detecting breast hamartomas, mammography is still a commonly used diagnostic test for breast abnormalities (1). However, it's essential to note that mammography may not be the most accurate method for diagnosing hamartoma.
  • Ultrasound scanning: Targeted ultrasound scanning can be recommended if an MRI image suggests malignancy, even if the lesion was hidden on mammography and the first ultrasound result was negative (2).
  • MRI scanning: MRI is considered a diagnostic imaging test of choice for breast hamartomas, as it can demonstrate localized collections of fat alternating with foci of calcification (3). However, in cases where mammography and ultrasound results are negative, MRI scanning may be recommended as the next step of assessment.
  • Fine Needle Aspiration Cytology (FNAC): FNAC has become a commonly performed diagnostic test for breast lumps, including hamartomas. A series of 25 cases of hamartoma reported that FNAC was useful in diagnosing this condition (11).
  • Core Needle Biopsy: Core needle biopsy sampling is expected to become more frequent as surgical procedures change, related to the increasing use of diagnostic procedures on breast lumps (6).

Other Diagnostic Tests

While not specifically mentioned in the context provided, other diagnostic tests like Positron Emission Tomography-Computed Tomography (PET-CT) and F-Fluorodeoxyglucose Positron Emission Tomography may also be used to determine if a lesion is malignant or benign.

References:

(1) [1] (2) [2] (3) [3] (6) [6] (11) [11]

Additional Diagnostic Tests

  • Fine Needle Aspiration Cytology (FNAC)
  • Core Needle Biopsy
  • Mammography
  • Ultrasound scanning
  • MRI scanning

Treatment

Based on the provided context, it appears that there are limited treatment options available for breast hamartomas.

According to search result [10], "The usual treatment for liposarcoma in the breast has been mastectomy or wide local excision." However, this information is related to a different condition (liposarcoma) and not specifically to breast hamartoma.

Search result [13] mentions that the usual treatment for liposarcoma in the breast has been mastectomy or wide local excision. However, it does not provide any specific information on drug treatment for breast hamartoma.

Search result [5] mentions that Sirolimus treatment led to an improvement of the patient's clinical status and a transient reduction of the thymus. However, this information is related to a different condition (PTEN hamartoma tumor syndrome) and not specifically to breast hamartoma.

Unfortunately, there does not seem to be any specific information on drug treatment for obsolete breast hamartoma in the provided search results.

Recommended Medications

  • mastectomy
  • wide local excision

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

Differential diagnosis of breast hamartoma involves considering other benign lesions that may present similarly

Breast hamartoma, a rare and benign tumor, can be challenging to diagnose due to its similarity in appearance to other well-defined lesions. The differential diagnosis for breast hamartoma includes:

  • Fibroadenoma/Phyllodes tumor: These tumors should not contain internal fat and are typically characterized by a distinct imaging appearance.
  • Lipoma: Lipomas, on the other hand, should contain homogeneous fat with minimal soft tissue, distinguishing them from hamartomas.
  • Myofibroblastoma: This rare benign lesion can mimic the appearance of hamartoma on imaging studies.
  • Adenomyoepithelioma: A rare tumor that can present similarly to hamartoma in terms of its imaging characteristics.

Imaging modalities play a crucial role in differential diagnosis

High-resolution ultrasound, duplex sonography, shear wave elastography, digital mammography, and minimally invasive intervention are some of the imaging methods used to differentiate between these lesions. However, it is essential to note that even with advanced imaging techniques, differential diagnosis can be challenging.

Clinical presentation and patient history also aid in differential diagnosis

The clinical presentation and patient history can provide valuable information for differential diagnosis. For instance, a patient's age, symptoms, and medical history can help clinicians narrow down the list of possible diagnoses.

References:

  • [6] states that the diagnosis of hamartoma is normally straightforward due to an extremely characteristic imaging appearance.
  • [9] discusses the possible heterogeneities between myoid hamartoma and capillary hemangioma using current breast imaging methods for differential diagnosis.
  • [10] lists some conditions that have overlapping presentations with hamartoma, including lipoma, lymphatic or vascular malformation, adenoma, fat necrosis, mucocele, and hypothalamic-chiasmatic glioma.

Additional Information

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