obsolete metabolic skin disease

Metabolic Skin Disease: An Obsolete Term

The term "obsolete metabolic skin disease" refers to a condition that was previously recognized as a distinct medical entity, but is no longer considered a valid diagnosis in modern medicine.

According to the available information [14], this term was used to describe a group of diseases characterized by abnormalities in metabolism that affect the skin. However, with advancements in medical knowledge and classification systems, this term has been replaced by more specific and accurate diagnoses.

The exact symptoms and characteristics of obsolete metabolic skin disease are not well-defined in the provided context. However, it is mentioned as a subclass of skin disease [14], suggesting that it was previously considered a distinct category within dermatology.

It's essential to note that medical terminology and classification systems evolve over time, and what was once considered a valid diagnosis may no longer be recognized or used in contemporary practice.

References:

[14] Context result 14: "metabolic disease with skin involvement; obsolete metabolic skin disease"

Based on the provided context, it appears that there are several metabolic skin diseases that have been identified in the past. Here are some signs and symptoms associated with these conditions:

• Multiple sulfatase deficiency: This rare hereditary metabolic disorder is characterized by impairment of all known sulfatase enzymes. Major symptoms include [5].
• Ichthyosis: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Vascular lesions: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Papular and nodular skin lesions: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Abnormal pigmentation: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Photosensitivity: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Skin laxity: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].
• Hair shaft: Cutaneous signs and symptoms may facilitate the diagnosis or can help in identifying complications or side effects of overtreatment of inherited metabolic diseases. The principal manifestations can be grouped into vascular lesions, ichthyosis, papular and nodular skin lesions, abnormal pigmentation, photosensitivity, skin laxity, hair shaft [15].

Please note that these conditions are considered obsolete, and the information provided is based on historical data. If you have any specific questions or concerns about a particular condition, I'll do my best to provide more information.

Obsolete Metabolic Skin Diseases: Diagnostic Tests

Metabolic skin diseases are conditions that affect the skin and are often linked to underlying metabolic disorders. While some diagnostic tests for these conditions may still be relevant today, others have been largely replaced by more modern and accurate methods.

• Tzanck testing: This test was once used to diagnose viral diseases such as herpes simplex and herpes zoster (1). However, it has largely been replaced by more specific and sensitive tests.
• Skin biopsy: A skin biopsy involves taking a sample of skin tissue for examination under a microscope. While still a useful diagnostic tool, some metabolic skin diseases may have overlapping symptoms with other conditions, making diagnosis more challenging (10).
• Patch testing: Patch testing is used to diagnose contact dermatitis and other allergic reactions. However, it may not be as relevant for diagnosing

Treatment Options for Obsolete Metabolic Skin Diseases

The context suggests that there are certain metabolic skin diseases that were once prevalent but have since become obsolete. However, the search results provide information on the treatment options for these conditions.

• Prednisolone: This corticosteroid was commonly used to treat various skin disorders, including atopic dermatitis and psoriasis vulgaris (1).

Differential Diagnosis of Obsolete Metabolic Skin Diseases

The differential diagnosis of obsolete metabolic skin diseases involves considering various conditions that present with similar symptoms, such as fibrosis, ichthyosis, and photosensitivity. According to [1], the differential diagnosis includes other diseases that present with fibrosis, such as scleromyxedema, systemic sclerosis, eosinophilia-myalgia syndrome, toxic oil syndrome, and others.

In addition, further differential diagnoses include phototoxic reactions, vesiculobullous form of polymorphous light eruption, and actinic prurigo [3]. The differential diagnosis also includes vasculitis, cholesterol embolization syndrome, warfarin-induced skin necrosis, nephrogenic fibrosing dermopathy, and porphyria cutanea tarda (MIM:176100) [4, 5].

It is essential to exclude other conditions that may present with similar symptoms, such as lichenoid drug eruptions, lichen planus pemphigoides, graft-vs. host disease, granuloma annulare, and inborn errors of metabolism [6, 9]. Inborn errors of metabolism should always be considered in the differential diagnosis, especially in infants with metabolic disorders [9].

Key Points:

• Differential diagnosis includes other diseases that present with fibrosis, such as scleromyxedema, systemic sclerosis, eosinophilia-myalgia syndrome, toxic oil syndrome, and others.
• Further differential diagnoses include phototoxic reactions, vesiculobullous form of polymorphous light eruption, and actinic prurigo.
• The differential diagnosis also includes vasculitis, cholesterol embolization syndrome, warfarin-induced skin necrosis, nephrogenic fibrosing dermopathy, and porphyria cutanea tarda (MIM:176100).
• Inborn errors of metabolism should always be considered in the differential diagnosis, especially in infants with metabolic disorders.

References:

[1] JM Leal · 2021 · Cited by 19 — The differential diagnosis is with other diseases that present with fibrosis (scleromyxedema, systemic sclerosis, eosinophilia-myalgia syndrome ...

[3] by P Lehmann · 2011 · Cited by 110 — Further differential diagnoses include phototoxic reactions, vesiculobullous form of polymorphous light eruption, and actinic prurigo.

[4] Mar 29, 2022 — The differential diagnosis includes vasculitis, cholesterol embolization syndrome, warfarin-induced skin necrosis, nephrogenic fibrosing ...

[5] Differential Diagnosis. Porphyria cutanea tarda (MIM:176100) is a condition that should be considered in the differential diagnosis.

[6] by P Lehmann · 2011 · Cited by 110 — The differential diagnosis also includes lichenoid drug eruptions, lichen planus pemphigoides, graft-vs. host disease, granuloma annulare, and inborn errors of metabolism.

[9] Inborn errors of metabolism should always be considered in the differential diagnosis, especially in infants with metabolic disorders.