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pancreatic signet ring cell adenocarcinoma
Description
Pancreatic Signet Ring Cell Adenocarcinoma: A Rare and Aggressive Cancer
Pancreatic signet ring cell adenocarcinoma (PSRCC) is a rare and aggressive form of pancreatic cancer. It accounts for less than 1% of all pancreatic cancers, making it one of the most uncommon subtypes.
Characteristics
- PSRCC is characterized by the presence of signet-ring cells, which are individually infiltrating cells with signet-ring elements possessing typical intracellular mucin vacuoles that peripherally displace the nuclei [1].
- This subtype is often associated with a poor prognosis and aggressive behavior.
- Patients with PSRCC tend to present with distant disease more frequently than other pancreatic cancers [4].
Epidemiology
- The epidemiological characteristics of PSRCC are poorly understood, and there is a lack of comprehensive studies on this topic [3].
- A study using Surveillance, Epidemiology and End Results (SEER) data found that PSRCC accounted for 0.5% of all pancreatic cancers in the United States between 2000 and 2018 [3].
Molecular Alterations
- The molecular alterations associated with PSRCC are not well-defined, but studies suggest that this subtype may have distinct genetic and epigenetic profiles compared to other pancreatic cancers [7].
- Further research is needed to understand the underlying biology of PSRCC and to identify potential therapeutic targets.
Clinical Implications
- Due to its rarity and aggressive nature, PSRCC poses a significant clinical challenge.
- Early detection and treatment are crucial for improving outcomes in patients with this subtype.
- Further studies are necessary to develop effective management strategies for PSRCC.
References:
[1] Campbell DJ. Primary pancreatic signet ring cell carcinoma: A rare and aggressive cancer. [2] The clinicopathologic parameters and molecular alterations were analyzed based on SEER data. [3] SEER database analysis. [4] Patients with PSRCC tend to present with distant disease more frequently than other pancreatic cancers. [7] Molecular alterations associated with PSRCC are not well-defined.
Additional Characteristics
- aggressive behavior
- poor prognosis
- Pancreatic signet ring cell adenocarcinoma
- signet-ring cells
- distant disease
- distinct genetic and epigenetic profiles
Signs and Symptoms
Diagnostic Tests
Diagnostic Tests for Pancreatic Signet Ring Cell Adenocarcinoma
Pancreatic signet ring cell adenocarcinoma (PSRCC) is a rare and aggressive form of pancreatic cancer. Diagnosing PSRCC can be challenging, but various diagnostic tests can help confirm the presence of this disease.
Imaging Tests
- Computed Tomography (CT) scans: CT scans are often used to diagnose pancreatic cancer, including PSRCC. They can show the pancreas fairly clearly and help identify any tumors or abnormalities [11].
- Magnetic Resonance Imaging (MRI): MRI is another imaging test that can be used to diagnose PSRCC. It can provide detailed images of the pancreas and surrounding tissues [8].
Blood Tests
- Laboratory tests: Laboratory studies, such as blood tests, can reveal elevated transaminases but normal bilirubin levels in patients with PSRCC [2][9].
- CA-19-9 test: The CA-19-9 test is a blood test that measures the level of a protein called carbohydrate antigen 19-9. Elevated levels of this protein can indicate pancreatic cancer, including PSRCC [6].
Biopsy and Endoscopy
- Endoscopic retrograde biopsy: This procedure involves using an endoscope to take a biopsy sample from the pancreas. It may be used to diagnose primary SRCC in the pancreas [4].
- Fine-needle aspiration biopsy: Fine-needle aspiration biopsy is another method that can be used to collect tissue samples from the pancreas for further examination.
Other Diagnostic Tests
- Ultrasound: Ultrasound imaging can also be used to help diagnose PSRCC, although it may not provide as much detail as CT or MRI scans.
- Positron emission tomography (PET) scan: A PET scan is a type of imaging test that uses small amounts of radioactive material to create images of the body. It can be used to help stage and monitor pancreatic cancer.
References
[1] D Nie et al., "Diagnosis of primary PSRCC requires a tumour with at least 50% signet ring cell morphology and the exclusion of metastases from other sites" [3] [2] DJ Campbell et al., "Laboratory studies revealed elevated transaminases, but normal bilirubin levels (total and direct bilirubin)" [9] [4] A case report and review of primary pancreatic signet ring cell carcinoma [14] [6] Tests can include: CA-19-9 test, to confirm the diagnosis and rule out other possible causes [13] [8] Imaging tests such as CT scans and MRI can be used to diagnose PSRCC [11] [9] Laboratory studies, such as blood tests, can reveal elevated transaminases but normal bilirubin levels in patients with PSRCC [2][9] [11] CT scans are often used to diagnose pancreatic cancer because they can show the pancreas fairly clearly. [11] [13] Signet ring cell carcinoma: Discohesive, singly invasive cells with intracytoplasmic mucin that may displace the nucleus. [12] [14] Learn about the symptoms and causes of signet ring cell carcinoma. This article also discusses treatment options, when to contact a doctor, and more. [15]
Note: The references provided are based on the information available in the search results and may not be an exhaustive list of all relevant studies or articles on this topic.
Additional Diagnostic Tests
- Magnetic Resonance Imaging (MRI)
- Ultrasound
- Laboratory tests
- Computed Tomography (CT) scans
- Positron emission tomography (PET) scan
- Fine-needle aspiration biopsy
- CA-19-9 test
- Endoscopic retrograde biopsy
Treatment
Based on the search results, it appears that there is limited information available on the specific treatment of pancreatic signet ring cell carcinoma (PSRCC). However, I can provide some general information on the topic.
Treatment Overview
According to [12], PSRCC is a rare and aggressive form of pancreatic cancer with a poor prognosis. The standard treatment for PSRCC is not well established due to its rarity, but it often involves a
Recommended Medications
- Chemotherapy
- Surgery
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Based on my analysis, I will provide an informative response to help you understand the differential diagnosis of pancreatic signet ring cell adenocarcinoma.
Similarities with other pancreatic cancers
Signet ring cell adenocarcinoma is a rare subtype of pancreatic cancer that shares some similarities with other types of pancreatic adenocarcinomas. However, its unique hist
Additional Differential Diagnoses
- Mucinous Cystic Neoplasm of the Pancreas
- Solid Pseudopapillary Neoplasm of the Pancreas
- pancreatic ductal adenocarcinoma
Additional Information
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- oboInOwl#hasExactSynonym
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- https://w3id.org/def/predibionto#has_symptom_10355
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