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prostate signet ring cell adenocarcinoma

Description

Prostate signet ring cell adenocarcinoma is a rare and aggressive form of prostate cancer characterized by the presence of signet ring cells in the tumor tissue.

  • Signet Ring Cells: These are malignant cells that have a distinctive appearance, with a large amount of cytoplasm and a small nucleus, resembling a signet ring. They are typically found in the glandular epithelium of the prostate.
  • Aggressive Behavior: Prostate signet ring cell adenocarcinoma is known to be highly aggressive, with a tendency to metastasize early and recur after treatment.

According to [1], this type of cancer accounts for only a small percentage of all prostate cancers, but it has a higher mortality rate due to its aggressive nature. The exact cause of signet ring cell adenocarcinoma is not well understood, but it is believed to be related to genetic mutations and environmental factors.

Symptoms of prostate signet ring cell adenocarcinoma may include:

  • Pain: Pain in the pelvic area or lower back
  • Urinary Issues: Difficulty starting or stopping urination, frequent urination, or weak urine flow
  • Weight Loss: Unintentional weight loss

Early detection and

Signs and Symptoms

Symptoms of Prostate Signet Ring Cell Adenocarcinoma

Prostate signet ring cell adenocarcinoma is a rare and aggressive form of cancer that can be challenging to diagnose in its early stages. Since symptoms may not appear until the cancer has spread, it's essential to understand what signs to look out for.

Common Symptoms:

  • Frequent urination (as mentioned in [6] and [11])
  • Induration and thickening of the bladder wall, similar to linitis plastica seen in signet ring cell carcinoma ([4] and [8])
  • High levels of PSA, which can be used to help diagnose signet ring cell prostate cancer ([9])

Other Possible Symptoms:

  • Erectile dysfunction (as mentioned in [12])
  • Difficulty swallowing or indigestion (similar to symptoms of esophageal adenocarcinoma, as mentioned in [12])
  • Coughing or hoarseness
  • Pressure or burning sensation in the chest

Important Notes:

  • Prostate signet ring cell adenocarcinoma is a rare and aggressive form of cancer.
  • Symptoms may not appear until the cancer has spread.
  • Early detection is crucial for effective treatment.

It's essential to consult with a healthcare professional if you experience any of these symptoms or have concerns about prostate health. They can provide personalized guidance and recommend further testing or treatment as needed.

Additional Symptoms

  • Frequent urination
  • Erectile dysfunction
  • Induration and thickening of the bladder wall
  • High levels of PSA
  • Difficulty swallowing or indigestion
  • Pressure or burning sensation in the chest
  • hoarseness

Diagnostic Tests

Diagnostic Tests for Prostate Signet Ring Cell Adenocarcinoma

Prostate signet ring cell adenocarcinoma is a rare and aggressive form of prostate cancer. Diagnosing this condition requires a combination of clinical evaluation, laboratory tests, and imaging studies.

  • Serum PSA test: A serum PSA (prostate-specific antigen) test can help diagnose signet ring cell prostate cancer. However, it's essential to note that a biopsy is needed to confirm the diagnosis [8].
  • Immunohistochemical studies: Immunohistochemical detection of PPSRCC usually shows positive PSA and PAP and negative carcinoembryonic antigen (CEA) in most cases [5].
  • Extraprostatic diagnostic workups: A series of extraprostatic diagnostic workups, including fibrogastroduodenoscopy, colonoscopy computed tomography imaging, are performed to rule out other possible locations for signet ring cells [4].
  • Transrectal ultrasonography-guided prostate biopsy: A transrectal ultrasonography-guided prostate biopsy can show signet ring cell carcinoma-like lesions, suggestive of adenocarcinoma [14].

Diagnostic Challenges

Diagnosing prostate signet ring cell adenocarcinoma can be challenging due to its rarity and similarity in presentation to other conditions. The presence of a primary signet ring cell carcinoma of the prostate was best confirmed by negative findings on gastrointestinal work-up, a positive stain for PSA, and negative carcinoembryonic antigen (CEA) [6].

References

  • Gu C. Y., Wu D. L., Huang S. S. (2009). Diagnosis and treatment of signet ring cell carcinoma of the prostate. Chinese Journal of Urology, 30(7), 487–489.
  • Sakalauskaite M et al. (2024) - not available online
  • Li P et al. (2022) - not available online
  • Warner JN et al. (2010) - not available online

Additional Diagnostic Tests

  • Immunohistochemical studies
  • Serum PSA test
  • Extraprostatic diagnostic workups
  • Transrectal ultrasonography-guided prostate biopsy

Treatment

Treatment Options for Prostate Signet Ring Cell Adenocarcinoma

Prostate signet ring cell adenocarcinoma is a rare and aggressive form of prostate cancer, accounting for only 0.02% of all cases of prostate cancer [12]. The treatment options for this condition are similar to those for traditional prostate cancer, but may be more aggressive due to its high-grade nature.

Hormone Therapy

Hormone therapy (HT) is a common treatment approach for prostate signet ring cell adenocarcinoma. This involves using medications to lower testosterone levels in the body, which can help slow down the growth of cancer cells [3]. According to a study by Al Khader et al., hormone therapy

Recommended Medications

  • Hormone Therapy

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

The differential diagnosis for prostate signet ring cell adenocarcinoma (SRCC) includes several conditions that can mimic its appearance on histopathology.

  • Metastatic carcinoma: SRCC often tends to be found in the presence of other high-grade adenocarcinoma of prostate histopathology patterns, which can make it challenging to distinguish from metastatic carcinoma, especially from gastrointestinal tumors [7].
  • Infiltrating lobular carcinomas: These are another type of cancer that can have a similar appearance to SRCC on histopathology. The main differential diagnoses are primary benign or atypical basal cell hyperplasia, which can also be considered in the differential diagnosis [9].
  • Secretory carcinomas: This is a rare type of cancer that can have a similar appearance to SRCC on histopathology.
  • Atrophy: Atrophy is a differential diagnosis to prostate cancer. It can appear as an admixture of spindled and pleomorphic cells with numerous mitotic figures, which can be similar to the appearance of SRCC [13].
  • Secondary signet ring cell carcinoma: This is another type of cancer that can have a similar appearance to SRCC on histopathology.
  • Primary benign or atypical basal cell hyperplasia: This is a rare condition that can mimic the appearance of SRCC on histopathology.

It's essential to perform upper gastric endoscopy, colonoscopy, cystoscopy, and other diagnostic tests to rule out these differential diagnoses and establish a definitive diagnosis of prostate signet ring cell adenocarcinoma [2].

References:

[7] Warner et al [9] J Li [13] George P.

Additional Differential Diagnoses

  • Atrophy
  • Infiltrating lobular carcinomas
  • Secretory carcinomas
  • Secondary signet ring cell carcinoma
  • Primary benign or atypical basal cell hyperplasia
  • obsolete metastatic carcinoma

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It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.