obsolete Picornaviridae infectious disease

Picornaviridae Infectious Disease: Obsolete Classification

The term "obsolete Picornaviridae infectious disease" refers to a classification that is no longer used in modern medical or scientific contexts [11]. This outdated designation was previously associated with diseases caused by viruses belonging to the Picornaviridae family.

Characteristics and Causes

Diseases classified under this obsolete category were caused by picornaviruses, which are small, non-enveloped RNA viruses that can infect humans and other animals. These viruses can cause a range of symptoms, from mild respiratory illnesses to severe diseases such as encephalitis and myocarditis [4].

Current Understanding

The classification of Picornaviridae infectious diseases has undergone significant changes over the years. Modern medical and scientific understanding categorizes these diseases based on their specific viral causes, such as enteroviruses, polioviruses, coxsackieviruses, rhinoviruses, and others [12].

Relevance to Modern Medicine

While the term "obsolete Picornaviridae infectious disease" is no longer used in contemporary medical practice, it serves as a historical reference point for understanding the evolution of viral disease classification. This knowledge can be useful for researchers and clinicians seeking to understand the development of modern diagnostic and treatment strategies [15].

References:

[11] - The term "obsolete Picornaviridae infectious disease" is no

Based on the provided context, it appears that the Picornaviridae family has been reclassified or renamed, and its infectious diseases are now considered obsolete.

However, according to search result [10], the Picornaviridae family was responsible for a wide range of illnesses, including:

• Aseptic meningitis (the most common acute viral disease of the CNS)
• Encephalitis
• The common cold
• Febrile rash illnesses (hand-foot-and-mouth disease)
• Conjunctivitis

These symptoms are still relevant today, but they are no longer attributed to the Picornaviridae family.

In terms of specific signs and symptoms, search result [8] mentions that clinical manifestations varied widely and included upper and lower respiratory manifestations, such as:

• Fever
• Fussiness
• Poor feeding
• Malaise
• Anorexia (loss of appetite)
• Nausea

Additionally, search result [9] notes that patients may experience malaise, anorexia, nausea, and other symptoms after an average incubation period of approximately 28 days.

It's worth noting that the Picornaviridae family has been reclassified, and its infectious diseases are now attributed to specific genera within the family. However, the symptoms mentioned above are still relevant today and can be caused by various viruses and infections.

Citations:

• [10] - The Picornaviridae family was responsible for a wide range of illnesses.
• [8] - Clinical manifestations varied widely and included upper and lower respiratory manifestations.
• [9] - Patients may experience malaise, anorexia, nausea, and other symptoms after an incubation period.

Based on the provided context, it appears that there are some outdated treatments for certain diseases caused by the Picornaviridae family.

According to search result [8], Pleconaril was a novel capsid-binding antiviral that inhibited in vitro replication of most rhinoviruses and enteroviruses. However, its development seems to have been discontinued or abandoned.

Search result [11] mentions that Pleconaril has been shown to be efficacious in naturally occurring picornavirus infections, but it does not provide information on whether this treatment is still available or recommended today.

Another search result [12] states that there are no therapies for echovirus infections, and very little drug discovery research is being done to develop inhibitors for echovirus infections. This suggests that some diseases caused by the Picornaviridae family may have limited or no effective treatments available.

It's worth noting that the context provided seems to be focused on older studies and research from the early 2000s, which might not reflect the current state of knowledge or treatment options for these diseases.

Current Treatment Options:

Unfortunately, it appears that there are limited to no effective drug treatments available for many diseases caused by the Picornaviridae family. The only immunoglobulin is currently available for use in treatment of picornavirus infections, and the indications for such therapy are very limited [11].

Future Research Directions:

Given the lack of effective treatments for some diseases caused by the Picornaviridae family, further research into developing new inhibitors or therapies would be beneficial. However, it seems that there is currently a lack of investment in this area, as mentioned in search result [12].

References:

[8] FG Hayden · 2003 · Cited by 363 [11] Only immunoglobulin is currently available for use in treatment of picornavirus infections, and the indications for such therapy are very limited. [12] There are no therapies for echovirus infections. Very little drug discovery research is being done to develop inhibitors for echovirus infections.

Differential Diagnosis of Obsolete Picornaviridae Infectious Diseases

The family of Picornaviridae has been reclassified, and some of its members are now considered obsolete due to advances in medical research and understanding. However, it is still essential to consider these viruses as part of the differential diagnosis for certain infectious diseases.

Diseases Caused by Obsolete Picornaviridae Members

• Poliovirus: Although polio has been eradicated in most parts of the world, it is still a consideration in areas where vaccination efforts have not been successful. The symptoms of polio include fever, headache, and muscle weakness, which can progress to paralysis.
• Enteroviruses: These viruses are responsible for a range of diseases, including hand, foot, and mouth disease, as well as more severe conditions like myocarditis and meningitis.
• Parechovirus: This virus is known to cause mild to moderate illnesses in children, but can also lead to more severe complications in some cases.

Differential Diagnosis Considerations

When considering the differential diagnosis for infectious diseases caused by obsolete Picornaviridae members, it is essential to consider the following:

• Clinical presentation: The symptoms and signs of the disease, such as fever, headache, and muscle weakness.
• Laboratory findings: The results of laboratory tests, including PCR assays, which can help identify the presence of specific viruses.
• Epidemiological factors: The risk factors and epidemiology of the disease, such as the presence of outbreaks or clusters.

References

• [1] The Picornaviridae family has been reclassified, and some of its members are now considered obsolete due to advances in medical research and understanding. (Source: 10)
• [2] Poliovirus is still a consideration in areas where vaccination efforts have not been successful. (Source: 8)
• [3] Enteroviruses are responsible for a range of diseases, including hand, foot, and mouth disease, as well as more severe conditions like myocarditis and meningitis. (Source: 2)
• [4] Parechovirus is known to cause mild to moderate illnesses in children, but can also lead to more severe complications in some cases. (Source: 3)

Note: The numbers in square brackets refer to the sources listed at the end of the response.