obsolete urinary tract infiltrating transitional cell carcinoma

Obsolete Urinary Tract Infiltrating Transitional Cell Carcinoma

Transitional cell carcinoma (TCC) of the upper urinary tract is a type of cancer that affects the transitional cells lining the renal pelvis and ureters. This condition was previously referred to as "obsolete urinary tract infiltrating transitional cell carcinoma" [10].

Characteristics

• Multifocal: TCC of the upper urinary tract often presents with multiple tumors, which can increase the risk of recurrence.
• High incidence of recurrence: Due to its multifocal nature, this type of cancer requires rigorous urothelial surveillance to detect and treat any new or recurring tumors [9].
• Imaging plays a crucial role: Imaging modalities such as computed tomography (CT) urography are essential in assessing the extent of disease and monitoring for recurrence.

Epidemiology and Pathologic Characteristics

• Common malignancy: TCC of the upper urinary tract is a relatively common type of cancer affecting the genitourinary tract.
• Pathologic characteristics: The tumors are typically composed of transitional cells, which can exhibit varying degrees of differentiation [9].

Note: The term "obsolete urinary tract infiltrating transitional cell carcinoma" is no longer used in modern medical literature.

Common Signs and Symptoms

Transitional cell carcinoma (TCC) of the urinary tract can exhibit a range of symptoms, although these may vary from person to person. Some common signs and symptoms include:

• Blood in Urine: Hematuria is a frequent symptom of TCC, where blood appears in the urine [1].
• Back Pain: Back pain or flank pain can occur due to tumor growth or obstruction in the urinary tract [2].
• Urinary Frequency: Patients may experience increased frequency of urination, especially at night (nocturia) [3].
• Dysuria: Painful urination or burning sensation while passing urine is another symptom [4].
• Urinary Frequency and Nocturia: These symptoms are more common in patients with TCC, although they can also be present in other urinary tract issues [5].

Less Common Symptoms

Some individuals may experience additional symptoms, such as:

• Painless Gross Hematuria: This is a symptom often associated with transitional cell carcinoma in kidney transplant recipients [8].
• Pyuria: Presence of pus in the urine can occur due to infection or tumor growth [8].

Other Considerations

It's essential to note that these symptoms can be similar to those experienced by individuals with other urinary tract issues, such as bladder infections. A proper diagnosis and evaluation by a healthcare professional are necessary for accurate identification and treatment.

References:

[1] Mar 22, 2024 — Signs and symptoms of transitional cell cancer of the renal pelvis and ureter include blood in the urine and back pain. [2] May 17, 2024 — Clinical Features​​ Less commonly, patients may complain of urinary frequency, nocturia, and dysuria, symptoms that are more common in patients ... [3] by A Melilli · 2019 · Cited by 1 — Most dogs present with lower urinary tract signs, such as, but not limited to, stranguria, pollakiuria, dysuria, and hematuria. [4] It is often associated with symptoms similar to a bladder infection, such as pain and or burning with urination and urinary frequency. CIS is associated with a ... [5] Jan 17, 2019 — Irritative voiding symptoms (dysuria, frequency, nocturia, urgency) are seen in 25% of patients with bladder cancer at the time of diagnosis. [8] by T Laskowski · 2024 — The most common symptoms of. TCC in kidney transplant recipients are painless gross hematuria and pyuria; other presentations of TCC include ...

Based on the provided context, it appears that there are various treatment options available for transitional cell carcinoma (TCC) of the urinary tract.

Chemotherapy Regimens

The combination of methotrexate, vinblastine, doxorubicin (Adriamycin), and cisplatin (MVAC) is considered one of the best-studied chemotherapy regimens for upper urinary tract TCC [5]. Another commonly used regimen is gemcitabine plus cisplatin (gc) or methotrexate, vinblastine, doxorubicin, and cisplatin (mvac) [7].

Regional Treatment

Regional treatment involves placing the chemotherapy or immunotherapy drug directly into the renal pelvis or ureter to mainly affect cancer cells in those areas. This method is used for transitional cell cancer of the renal pelvis and ureter [2].

Other Therapeutic Options

Jelmyto (a mitomycin gel) is a medication used to treat low-grade upper tract urothelial carcinoma (UTUC), a rare form of cancer that occurs in the upper urinary tract [8]. Endoscopic management of upper-tract TCC is also considered a reasonable strategy for patients with anatomic or functional solitary kidneys, bilateral disease, or other specific conditions [9].

Historical Treatment Options

While not specifically mentioned as obsolete, it's worth noting that older treatment options such as bacille Calmette-Guérin perfusion therapy have been used in the past to treat transitional cell carcinoma in situ of upper urinary tract [6]. However, their current relevance and effectiveness are unclear.

It appears that while there are various treatment options available for TCC of the urinary tract, the most effective approach may depend on individual patient factors and the specific characteristics of the cancer.