obsolete vitamin E deficiency

Based on the provided context, it appears that there are some outdated methods for diagnosing vitamin E deficiency.

• The hydrogen peroxide-induced erythrocyte lysis test (mentioned in search result 3) is an obsolete method for defining vitamin E status and assessing its levels. This test has been replaced by more sensitive and specific PCR methods (search result 5).
• Another outdated diagnostic test mentioned is the peroxide hemolysis test, which was used to evaluate vitamin E deficiency in a study published in 2001 (search result 4).

It's worth noting that these tests are no longer recommended for diagnosing vitamin E deficiency due to their limited sensitivity and specificity.

Instead, modern diagnostic approaches focus on measuring vitamin E levels directly through blood tests (search results 6 and 14). These tests can accurately assess the amount of vitamin E in the body and help diagnose deficiencies or excessive intake.

In summary:

• Obsolete diagnostic tests for vitamin E deficiency include:
  • Hydrogen peroxide-induced erythrocyte lysis test
  • Peroxide hemolysis test
• Modern diagnostic approaches involve measuring vitamin E levels through blood tests.

Treatment Options for Vitamin E Deficiency

Vitamin E deficiency can be treated with various medications, which are aimed at replenishing the body's stores of this essential nutrient.

• Alpha-tocopherol: This is a synthetic form of vitamin E that is commonly used to treat vitamin E deficiency. It is available in oral and injectable forms.
  • Usual Adult Dose for Vitamin E Deficiency: Abetalipoproteinemia: approximately 100 mg/kg or 5 to 10 grams alpha-tocopherol per day [14].
• Vitamin E supplementation: This involves taking vitamin E supplements orally to help replenish the body's stores of this nutrient.
  • Vitamin E supplementation is indicated for treatment of vitamin E deficiency which can occur in cystic fibrosis, cholestasis and severe liver disease, abetalipoproteinemia or simply poor diet [15].

Important Considerations

When treating vitamin E deficiency with medications, it is essential to consider the following:

• Dosage: The dosage of alpha-tocopherol may need to be adjusted based on individual factors such as age, weight, and underlying health conditions.
  • Usual Adult Dose for Vitamin E Deficiency: Abetalipoproteinemia: approximately 100 mg/kg or 5 to 10 grams alpha-tocopherol per day [14].
• Interactions: Certain medications may interact with vitamin E supplements, which can affect their efficacy and safety.
  • Use of vitamin E with these drugs, herbs and supplements to reduce blood clotting might increase the risk of bleeding. Cytochrome P450 3A4 (CYP3A4) substrates. Use caution when taking vitamin E and other drugs affected by these enzymes, such as omeprazole (Prilosec, Zegerid). Statins and niacin [10].

References

[14] Drugs.com Mobile App. Access drug & treatment information, identify pills, check interactions and set up personal medication records.

[15] Vitamin E supplementation is indicated for treatment of vitamin E deficiency which can occur in cystic fibrosis, cholestasis and severe liver disease, abetalipoproteinemia or simply poor diet