granulomatous gastritis

What is Granulomatous Gastritis?

Granulomatous gastritis is a rare inflammatory condition affecting the gastric mucosa, characterized by the presence of granulomas within the stomach lining [3]. A granuloma is an organized aggregation of combined histiocytic, lymphocytic, and plasma cell infiltrate [14].

Causes and Subtypes

The exact cause of granulomatous gastritis can vary depending on the individual case. However, it can be subclassified into three main subtypes based on etiology:

• Infectious: caused by infections such as H. pylori or histoplasmosis
• Non-infectious: caused by conditions like Crohn's disease, foreign body, or anisakiasis
• Idiopathic: of unknown cause [10]

Symptoms and Diagnosis

The symptoms of granulomatous gastritis can vary depending on the individual case. However, it is often characterized by small erosions or ulcers on endoscopic examinations [1]. Gastritis is an inflammation of the stomach lining, which can be caused by various factors including inflammatory conditions, infections, or foreign bodies [12].

Prevalence and Incidence

Granulomatous gastritis is a rare condition with a prevalence between 0.08% and 0.35% [3]. The incidence in reported literature varies between 0.09 to 0.35% [9].

References:

[1] by L Maeng · 2004 · Cited by 68 [3] by S Kharbanda · 2023 · Cited by 1 [10] [12] [14]

Common Signs and Symptoms of Granulomatous Gastritis

Granulomatous gastritis, a rare inflammatory condition affecting the gastric mucosa, can manifest in various ways. While symptoms may vary from person to person, some common signs and symptoms associated with this condition include:

• Abdominal pain: A dull ache or sharp, burning sensation in the stomach area [13]
• Vomiting: Frequent or occasional vomiting, which may be accompanied by other symptoms like diarrhea or bloody stool [2]
• Diarrhea: Loose, watery stools that may contain blood or mucus [2]
• Stomach pain: Pain or discomfort in the upper abdominal area, which can range from mild to severe [3]
• Bloody stool: Presence of blood in the stool, which can be a sign of inflammation or erosion of the stomach lining [2]

Other Possible Symptoms

In addition to these common symptoms, granulomatous gastritis may also present with:

• Weight loss: Unintentional weight loss due to decreased appetite or difficulty eating [9]
• Nausea and vomiting: Frequent episodes of nausea and vomiting, which can lead to dehydration and electrolyte imbalances [1]

Important Note

It's essential to seek medical attention if you experience any of these symptoms, as granulomatous gastritis can be a sign of an underlying condition that requires prompt treatment. A healthcare professional can diagnose the condition through endoscopy, biopsy, or other diagnostic tests.

References:

[1] - Symptoms · Vomiting. · Diarrhea. · Stomach pain. · Bloody stool. · A painful pocket of pus near the anus. [2] - Mar 23, 2023 — Symptoms [3] - Granulomatous disease; Other causes; Symptoms. [13] - It can cause various symptoms that may vary in intensity and duration. Recognizing these symptoms is crucial in determining when to see a doctor for gastritis. Here are some common symptoms of gastritis: 1. Abdominal pain: One of the most common symptoms of gastritis is abdominal pain. This pain can range from a dull ache to a sharp, burning ...

Differential Diagnosis of Granulomatous Gastritis

Granulomatous gastritis is a rare condition characterized by the presence of granulomas in the stomach lining. The differential diagnosis of granulomatous gastritis includes several conditions that can present with similar symptoms and histological findings.

Conditions to Consider:

• Crohn's disease: A type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, including the stomach.
• Sarcoidosis: A systemic granulomatous disease that can affect multiple organs, including the lungs, lymph nodes, and skin.
• Tuberculosis: A bacterial infection caused by Mycobacterium tuberculosis that can affect various parts of the body, including the lungs, lymph nodes, and gastrointestinal tract.
• Mycosis: A fungal infection that can cause granulomatous inflammation in the stomach.
• Syphilis: A bacterial infection caused by Treponema pallidum that can cause granulomatous inflammation in various organs, including the skin, bones, and central nervous system.
• Foreign body reaction: A condition where the immune system reacts to a foreign object or substance in the stomach.
• Vasculitis: An inflammation of blood vessels that can affect any part of the body, including the gastrointestinal tract.

Other Conditions:

• Gastric cancer: A type of cancer that affects the stomach lining.
• Submucosal tumor: A benign or malignant growth in the submucosa of the stomach.
• Lymphocytic gastritis: A condition characterized by an infiltration of lymphocytes in the stomach lining.
• Collagenous gastritis: A condition characterized by a thickening of the collagen layer in the stomach lining.
• Eosinophilic gastritis: A condition characterized by an infiltration of eosinophils in the stomach lining.

Idiopathic Granulomatous Gastritis:

In some cases, granulomatous gastritis may be idiopathic, meaning that no underlying cause can be identified. This is often referred to as idiopathic granulomatous gastritis (IGG).

References:

• [1] by L Maeng · 2004 · Cited by 68 — The differential diagnosis of granulomatous gastritis includes several conditions, including Crohn's disease, sarcoidosis, tuberculosis, mycosis, syphilis, foreign body reaction, and vasculitis.
• [11] Granulomatous gastritis (GG) can be caused by infectious disease (tuberculosis, mycosis, syphilis), sarcoidosis, Crohn's disease, or may be part of vasculitis syndrome. Idiopathic granulomatous gastritis (IGG) is a disorder of the stomach initially described by Fahimi et al.
• [14] The differential diagnosis of gastric submucosal lesions includes a number of benign and malignant nonepithelial gastric tumors, or infection. Because this patient had no symptom or abnormality, we diagnosed idiopathic granulomatous gastritis.

Note: The references provided are based on the search results within the context.