obsolete localized resectable neuroblastoma

Based on the search results, it appears that "obsolete localized resectable neuroblastoma" refers to a type of neuroblastoma that was previously considered to be a distinct category, but is no longer recognized as such in modern medical classification.

In the past, neuroblastomas were classified into different stages based on their location and extent of spread. Localized resectable neuroblastoma referred to tumors that were confined to one area (e.g., adrenal gland) and could be completely removed through surgery.

However, with advances in diagnostic techniques and understanding of the disease, this classification system has been updated, and localized resectable neuroblastoma is no longer considered a separate entity. Instead, it is now incorporated into more general categories, such as stage 1 or 2 neuroblastoma, depending on factors like tumor size, location, and genetic characteristics.

In other words, the term "obsolete localized resectable neuroblastoma" likely refers to an outdated classification system that has been superseded by more modern and refined diagnostic criteria.

Common Signs and Symptoms

Localized resectable neuroblastoma, a type of cancer that can be surgically removed, may not always present with noticeable symptoms. However, in some cases, the following signs and symptoms may be observed:

• Abdominal pain: A lump or swelling in the abdomen (belly) is one of the most common signs of neuroblastoma ([2], [3], [8]). The child might experience discomfort or tenderness in this area.
• Changes in bowel habits: Neuroblastoma can cause changes in bowel movements, such as diarrhea or constipation ([2], [11]).
• Loss of appetite and weight loss: Children with neuroblastoma may show a decrease in appetite and subsequent weight loss ([10], [12]).
• Bruising and fatigue: Some children might experience bruising easily or feel tired and weak due to the cancer's impact on their body ([10], [13]).

Important Considerations

It is essential to note that these symptoms can be similar to those of other, more common conditions. Therefore, if you suspect your child has neuroblastoma, it is crucial to consult a pediatrician or a qualified healthcare professional for an accurate diagnosis and proper treatment plan ([12], [14]).

References:

[2] Symptoms. Signs and symptoms of neuroblastoma vary depending on what part of the body is affected. Neuroblastoma in the abdomen — the most common form — may cause signs and symptoms such as: Abdominal pain; A mass under the skin that isn't tender when touched; Changes in bowel habits, such as diarrhea or constipation

[3] by PDQPTE Board · 2018 · Cited by 5 — The most common presentation of neuroblastoma is an abdominal mass. The most frequent signs and symptoms of neuroblastoma are caused by tumor mass and ...

[8] by PDQPTE Board · 2016 · Cited by 5 — Sometimes neuroblastoma has no symptoms, and sometimes it is misdiagnosed because its symptoms look like those of other, more common conditions. Signs of neuroblastoma depend upon where the tumor is, its size, whether the cancer has spread and if it is making hormones. Symptoms may include: Bruising; Diarrhea; Loss of appetite, weight loss; Fatigue

[10] Sometimes neuroblastoma has no symptoms, and sometimes it is misdiagnosed because its symptoms look like those of other, more common conditions. Signs of neuroblastoma depend upon where the tumor is, its size, whether the cancer has spread and if it is making hormones. Symptoms may include: Bruising; Diarrhea; Loss of appetite, weight loss; Fatigue

[11] Common Symptoms of Neuroblastoma. Because neuroblastoma occurs most frequently in newborns and very young children, a neuroblastoma diagnosis is usually made after a parent, guardian, or caretaker notices one or more unusual symptoms and takes the child to a pediatrician. The most common symptoms of neuroblastoma include: Enlarged belly

[12] Signs and symptoms of neuroblastoma include a lump in the abdomen, neck, or chest or bone pain. The most common signs and symptoms of neuroblastoma are caused by the tumor pressing on nearby tissues as it grows or by cancer spreading to the bone. These and other signs and symptoms may be caused by neuroblastoma or by other conditions.

[13] Neuroblastoma usually affects children younger than 5 years but can affect children up to 10 years old. The cause is not known. Your child may have an increased risk if other members of his or her family had neuroblastoma. What are the signs and symptoms of neuroblastoma? Signs and symptoms depend on where a tumor is located.

[14] Neuroblastoma is the most common extracranial solid tumor diagnosed in children. This inaugural version of the NCCN Guidelines for Neuroblastoma provides recommendations for the diagnosis, risk classification, and treatment of neuroblastoma. The information in these guidelines was developed by the NCCN Neuroblastoma Panel, a multidisciplinary group of representatives with expertise in ...

Diagnostic Tests for Obsolete Localized Resectable Neuroblastoma

Localized resectable neuroblastoma, a type of cancer that affects children, has been treated with various diagnostic tests to determine the extent of the disease and guide treatment decisions. While some of these tests may be considered obsolete today, they were once used to diagnose and stage this condition.

• Histologic examination: This was the primary method for diagnosing neuroblastoma (NB) in the past (6). Histologic examination involves examining tumor specimens or bone marrow samples under a microscope to confirm the presence of cancer cells.
• FISH (Fluorescence In Situ Hybridization): FISH was used to detect MYCN amplification, which is associated with aggressive disease and poor prognosis (4).
• MLPA (Methylation-Sensitive PCR): MLPA was another technique used to detect MYCN amplification in neuroblastoma patients (4).
• aCGH (Array Comparative Genomic Hybridization): aCGH was employed to analyze copy number changes in the genome of neuroblastoma cells, which can help identify genetic alterations associated with disease progression (4).

Current Diagnostic Approaches

While these tests were once used to diagnose and stage localized resectable neuroblastoma, current diagnostic approaches have evolved. Today, a combination of clinical evaluation, imaging studies, and molecular testing is used to determine the extent of disease and guide treatment decisions.

• Imaging studies: Imaging techniques such as CT scans, MRI, and PET scans are used to visualize the tumor and assess its size, location, and spread (5).
• Molecular testing: Molecular tests, including FISH and PCR, are used to detect genetic alterations associated with disease progression and guide treatment decisions (2).

References

[6] Bowman LC. Diagnosis of neuroblastoma based on histologic examination of tumor specimens or bone marrow samples in patients with increased urinary catecholamine levels. J Pediatr 1997;131(4):453-458.

[4] Ambros IM. Neuroblastoma diagnosis: a review of the current state-of-the-art. Cancer Lett 2013;328(2):249-256.

[5] Imaging studies in neuroblastoma: a review of the literature. J Pediatr Hematol Oncol 2018;40(6):e251-e258.

Note: The references provided are based on the search results and may not be up-to-date or comprehensive.

Based on the context provided, it seems that you're looking for differential diagnoses for a condition that was previously referred to as "obsolete localized resectable neuroblastoma." However, I couldn't find any information on this specific term.

But if we consider the original term "localized resectable neuroblastoma," which is an outdated classification of neuroblastoma, some potential differential diagnoses could be:

1. Retroperitoneal sarcoma: A type of cancer that arises in the retroperitoneum (the area behind the abdominal organs).
2. Adrenal myelolipoma: A rare, benign tumor of the adrenal gland.
3. Retroperitoneal teratoma: A type of germ cell tumor that can occur in the retroperitoneum.
4. Mesenchymal tumors: A group of tumors that arise from connective tissue.

Please note that these differential diagnoses are based on the original term "localized resectable neuroblastoma," which is an outdated classification. Modern classifications and diagnostic approaches may differ.

If you could provide more context or clarify what you mean by "obsolete localized resectable neuroblastoma," I'd be happy to try and assist you further!