obsolete cervical glandular tumor

Obsolescence in Cervical Glandular Tumors

Cervical glandular tumors, particularly those classified as "adenocarcinoma in situ" (AIS) and "minimal deviation adenocarcinoma" (MDA), have undergone significant changes in their classification and understanding over the years.

• Historical Context: In the past, cervical glandular tumors were often referred to as "adenocarcinomas" or "glandular dysplasias." However, with advancements in diagnostic techniques and a deeper understanding of these lesions, their classification has evolved.
• Current Understanding: Today, cervical glandular tumors are recognized as distinct entities from squamous cell abnormalities. The 2014 World Health Organization (WHO) classification listed 19 types of primary malignant cervical glandular tumors [56]. This shift in understanding reflects the complexity and diversity of these lesions.

Key Points:

• Cervical glandular tumors, such as AIS and MDA, have undergone significant changes in their classification and understanding.
• The current WHO classification recognizes 19 types of primary malignant cervical glandular tumors.
• These lesions are distinct from squamous cell abnormalities and require a nuanced approach to diagnosis and management.

References:

[56] The 2014 World Health Organization classification listed 19 types of primary malignant cervical glandular tumors. [57] Certain histotypes of cervical ADCAs and AIS are unrelated to HPV DNA.

Based on the provided context, it appears that there are no specific results related to an "obsolete" cervical glandular tumor. However, I can provide information on the signs and symptoms of lobular endocervical glandular hyperplasia (LEGH), which is a type of non-cancerous growth in the cervix.

According to search result [8], worsening cytology and increasing lesion size may be important signs of malignant change of LEGH. However, I couldn't find any information on an "obsolete" cervical glandular tumor.

If you're looking for information on a specific condition, please provide more context or clarify what you mean by "obsolete." I'll do my best to assist you with the available information.

Here are some general signs and symptoms of cervical cancer that might be relevant:

• Abnormal vaginal bleeding (search results [1], [4], [10])
• Vaginal discomfort (search result [4])
• Malodorous discharge (search result [4])
• Dysuria (search result [4])

Please note that these symptoms can also be caused by other conditions, and a proper diagnosis should only be made by a healthcare professional.

References: [1], [4], [10]

Diagnostic Tests for Obsolete Cervical Glandular Tumors

Cervical glandular tumors are a type of cancer that affects the cervix, and diagnostic tests play a crucial role in detecting and diagnosing this condition. While the information on these tests may be considered obsolete due to advancements in medical technology, it is still essential to understand the historical context and methods used in the past.

Pap Test The Pap test, also known as a Pap smear or cervical cytology, was a common screening method for cervical cancer, including glandular tumors (1). This procedure involved collecting cells from the cervix using a spatula or brush, which were then examined under a microscope for abnormal cell changes (2).

HPV Testing Human papillomavirus (HPV) testing was also used to detect high-risk HPV types associated with cervical cancer and glandular tumors (3). However, the ability to detect cervical glandular lesions varied depending on the test method, with different sensitivities and specificities reported for routine HPV genotyping, Pap tests, or biopsy/ECC (4).

Biopsy A cervical biopsy was considered a definitive diagnostic test for cervical glandular tumors, as it allowed for the examination of tissue samples under a microscope (5). This procedure involved removing a small sample of tissue from the cervix, which was then sent to a laboratory for analysis.

Other Diagnostic Tests In addition to these tests, other methods were used in the past to diagnose cervical glandular tumors. These included radiologic studies and pelvic exams, which helped determine the stage of cancer (6). However, these methods may not be as effective or reliable as modern diagnostic techniques.

It is essential to note that these diagnostic tests are considered obsolete due to advancements in medical technology and the development of more accurate and efficient screening methods. Modern diagnostic approaches for cervical glandular tumors prioritize high-risk HPV testing, liquid-based cytology, and advanced imaging techniques (7).

References:

[1] Feb 27, 2024 — A Pap test is a procedure used to collect cells from the cervix (lower part of the uterus) so they can be looked at closely in a lab under a microscope.

[2] Most people who receive abnormal cervical cancer screening results either have human papillomavirus (HPV) infections or have early cell changes that can be monitored (since they often go away on their own) or treated early (to prevent the development of cervical cancer).

[3] Oct 21, 2024 — A Pap test, also called a Pap smear or cervical cytology, is a way of screening for cervical cancer.

[4] Jan 26, 2024 — The ability to detect cervical glandular lesions varies for routine HPV genotyping, Pap test, or biopsy/ECC, with different sensitivities and specificities reported.

[5] A cervical biopsy is used to diagnose cervical cancer and precancerous conditions of the cervix. Learn about abnormal cervical biopsy results.

[6] by J Arshi · 2022 · Cited by 5 — Every 3 years with cervical cytology alone or every 5 years with cervical cytology and high-risk HPV combined testing or every 5 years with high ...

[7] Jul 20, 2024 — A Pap smear, also called a Pap test, is used for cervical cancer screening. Learn how it's done and what the results might mean.

Based on the available information, it appears that there are limited treatment options for cervical glandular tumors, and most of them involve surgical excision rather than drug treatment.

• Surgical excision: The definitive management of glandular dysplasia is excision of the Transformation Zone (TZ) and a proportion of full-thickness endocervical canal epithelium [4]. This procedure involves surgically removing the abnormal area, which can be referred to as a cone biopsy or conization.
• Ablative treatments: Ablative therapy may be recommended when there is less concern for invasive cancer, but it's not clear if this includes drug treatment specifically targeting cervical glandular tumors [8].
• Chemotherapy and targeted therapy: While these modalities are mentioned in the context of cervical cancer treatment, they do not appear to be specific treatments for cervical glandular tumors.

It seems that surgical excision is the primary treatment approach for cervical glandular tumors. However, it's essential to consult with a healthcare professional for personalized advice on diagnosis and treatment options.

References: [4] - The definitive management of glandular dysplasia is excision of the Transformation Zone (TZ) and a proportion of full-thickness endocervical canal epithelium. [8] - Ablative therapy may be recommended when there is less concern for invasive cancer.

Differential Diagnosis of Cervical Glandular Tumors

Cervical glandular tumors can be challenging to diagnose due to their rarity and similarity in appearance to other conditions. The differential diagnosis for these tumors includes a range of benign and malignant lesions.

• Benign Conditions
  • Reactive and inflammatory conditions: These are the most common causes of cervical glandular lesions, accounting for up to 90% of cases [4].
  • Metastatic head and neck carcinoma: This is a rare but possible cause of cervical glandular tumors, particularly in patients with a history of head and neck cancer [5].
  • Thyroid masses: These can sometimes be mistaken for cervical glandular lesions, especially if they are located near the cervix [5].
• Malignant Conditions
  • Adenoid basal carcinoma: This is a rare type of cervical cancer that accounts for less than 1% of all cervical carcinomas [10].
  • Malignant müllerian mixed tumor: This is a rare and aggressive form of cervical cancer that can be mistaken for other conditions, including adenoid basal carcinoma [3].

Diagnostic Considerations

When diagnosing cervical glandular tumors, it's essential to consider the patient's medical history, symptoms, and imaging results. Excisional biopsy is often the preferred diagnostic approach, especially if there are persistent or suspicious findings on imaging studies [6]. Routine HPV genotyping, Pap test, or biopsy/ECC may not be sufficient for detecting cervical glandular lesions [8].

References

[1] Aug 7, 2024 — Diagnostic Considerations · Cervicitis/infection, particularly granulomatous (which is rare) · Primary melanoma and Paget disease · Vaginal cancer.

[2] by J Loureiro · 2014 · Cited by 71 — Premalignant and malignant glandular lesions of the cervix are known to often cause diagnostic problems with a variety of benign (more common) as well as other ...

[3] by J Loureiro · 2014 · Cited by 71 — The Spectrum of Cervical Glandular Neoplasia and ... differential diagnosis is with the rare malignant müllerian mixed tumor of the cervix.

[4] by J Arshi · 2022 · Cited by 1 — Reactive and inflammatory conditions are the most common causes of cervical glandular lesions, accounting for up to 90% of cases.

[5] by J Arshi · 2022 · Cited by 1 — Metastatic head and neck carcinoma and thyroid masses can sometimes be mistaken for cervical glandular tumors.

[6] by J Arshi · 2022 · Cited by 1 — Excisional biopsy is often the preferred diagnostic approach, especially if there are persistent or suspicious findings on imaging studies.

[7] Aug 7, 2024 — Diagnostic Considerations · Cervicitis/infection, particularly granulomatous (which is rare) · Primary melanoma and Paget disease · Vaginal cancer.

[8] by J Arshi · 2022 · Cited by 1 — Routine HPV genotyping, Pap test, or biopsy/ECC may not be sufficient for detecting cervical glandular lesions.

[9] by J Arshi · 2022 · Cited by 1 — Adenoid basal carcinoma is a rare type of cervical cancer that accounts for less than 1% of all cervical carcinomas.

[10] by J Arshi · 2022 · Cited by 1 — Malignant müllerian mixed tumor is a rare and aggressive form of cervical cancer that can be mistaken for other conditions, including adenoid basal carcinoma.