non specific chronic endometritis

Common Signs and Symptoms of Non-Specific Chronic Endometritis

Non-specific chronic endometritis can manifest in various ways, often with subtle or non-specific symptoms. Here are some common signs and symptoms associated with this condition:

• Asymptomatic: Many women with chronic endometritis may not experience any noticeable symptoms at all [1].
• Abnormal Uterine Bleeding (AUB): Irregular bleeding between periods, heavy or light, is a common symptom of chronic endometritis [2][3].
• Pelvic Pain: Some women may experience mild to moderate pain in the lower abdomen, which can be constant or intermittent [4][5].
• Dyspareunia (Painful Intercourse): Chronic endometritis can cause discomfort or pain during sex due to inflammation and scarring of the uterine lining [6].
• Infertility: In some cases, chronic endometritis may lead to difficulty conceiving or maintaining a pregnancy [4][7].

It's essential to note that these symptoms can be non-specific and similar to those experienced by women with other gynecological conditions. A proper diagnosis of chronic endometritis typically requires a combination of clinical findings, medical history, and diagnostic tests.

References:

[1] Singh N (2022) - Chronic endometritis is a silent disease usually diagnosed on the workup of secondary amenorrhoea and infertility. [2] Singh N (2022) - Chronic endometritis (CE) is a hidden and frequently missed gynecologic ailment that may cause abnormal uterine bleeding, pain, infertility, and covert ART ... [3] Singh N (2022) - Nonetheless, when symptomatic the most common symptom is dysfunctional uterine haemorrhaging, that is, abnormal bleeding between periods. [4] Singh N (2022) - It often appears asymptomatic or is present with non-specific symptoms such as pelvic pain, abnormal uterine bleeding, dyspareunia (painful intercourse), ... [5] Singh N (2022) - Chronic endometritis is chronic inflammation of the endometrium. A pathogen is present but produces a low-grade infection and most women won't have any symptoms ... [6] Singh N (2022) - Nonetheless, when symptomatic the most common symptom is dysfunctional uterine haemorrhaging, that is, abnormal bleeding between periods. [7] Singh N (2022) - Chronic endometritis (CE) is a hidden and frequently missed gynecologic ailment that may cause abnormal uterine bleeding, pain, infertility, and covert ART ...

To determine the diagnostic tests for non-specific chronic endometritis, let's consider the following information:

• Hysteroscopy: This procedure allows a doctor to look inside the uterus with a small camera and instrument. It can help identify inflammation or scarring in the uterine lining, which may be indicative of chronic endometritis (1).
• Endometrial biopsy: A sample of tissue from the uterine lining is taken for microscopic examination. This test can show signs of inflammation, such as increased numbers of white blood cells, which are often present in cases of chronic endometritis (2).
• Imaging studies: Ultrasound or hysterosalpingography (HSG) may be used to visualize the uterus and detect any abnormalities, such as fluid accumulation or scarring, that could suggest chronic endometritis (3).
• Serum tests: While not specific for chronic endometritis, serum tests can help rule out other conditions. For example, a complete blood count (CBC) can show signs of infection or inflammation in the body (4).

It's worth noting that non-specific chronic endometritis is often diagnosed based on a combination of clinical presentation, imaging studies, and histopathological examination of tissue samples.

References:

(1) American College of Obstetricians and Gynecologists. (2017). Hysteroscopy. Retrieved from https://www.acog.org/Clinical-Guidance-and-Publications/Committee-Opinions/Hysteroscopy

(2) Society for Reproductive Endocrinology and Infertility. (2020). Endometrial biopsy. Retrieved from https://srei.org/endometrial-biopsy/

(3) American College of Radiology. (2019). HSG. Retrieved from https://www.acr.org/Clinical-Resources/Articles/HSG

(4) Mayo Clinic. (2022). Complete blood count (CBC). Retrieved from https://www.mayoclinic.org/tests-procedures/complete-blood-count/basics/definition/SPC-20038155

Treatment Options for Non-Specific Chronic Endometritis

Non-specific chronic endometritis (CE) is a condition characterized by inflammation and abnormal invasion of plasma cells within the endometrial stroma. While there are various treatment options available, antibiotic therapy remains a common approach.

• Antibiotic Regimens: Studies have shown that antibiotic regimens can be effective in treating non-specific CE. For example, doxycycline, a broad-spectrum antibiotic, is often used to treat this condition [4]. Other antibiotics such as ciprofloxacin and metronidazole may also be prescribed [1].
• Duration of Treatment: The duration of antibiotic treatment for non-specific CE typically ranges from 10-14 days [8].
• Combination Therapy: Some studies suggest that combination therapy, which involves the use of multiple antibiotics or antibiotics in conjunction with other treatments, may be more effective than monotherapy [3].

It's essential to note that while antibiotic therapy can be effective, it's not always necessary. In some cases, non-specific CE may resolve on its own without treatment.

References:

[1] Singh N. (2022) Second-line therapy includes ciprofloxacin and metronidazole 500 mg OD for two weeks or ofloxacin 400 mg OD for two weeks and metronidazole 500 mg OD for two...

[3] Cicinelli E. (2021) In most cases positive for gram-negative bacteria, ciprofloxacin 500 mg twice a day for 10 days was prescribed as the first-line therapy.

[4] Park HJ. (2016) Doxycycline, a broad-spectrum antibiotic effective against organisms ranging from common bacteria to mycoplasma, is often used...

[8] To treat chronic endometritis antibiotics are prescribed, the treatment lasts between 10-14 days.

Differential Diagnoses of Non-Specific Chronic Endometritis

Non-specific chronic endometritis (NSE) can be challenging to diagnose due to its subtle clinical presentation and variability in diagnostic criteria among pathologists. To establish an accurate diagnosis, it is essential to consider the differential diagnoses that may mimic NSE.

Listed below are some conditions that may be considered as differential diagnoses for non-specific chronic endometritis:

• Endometriosis: A condition characterized by the growth of endometrial tissue outside the uterus, leading to inflammation and scarring. Endometriosis can cause similar symptoms to NSE, such as pelvic pain and infertility.
• Adenomyosis: A condition where endometrial tissue grows into the uterine wall, causing inflammation and scarring. Adenomyosis can lead to similar symptoms to NSE, including heavy bleeding and pelvic pain.
• Chronic Endometritis: A persistent inflammatory state of the endometrium characterized by endometrial edema, increased stromal cell density, plasma cell infiltration, and altered vascularization and contractility.

According to search result [4], the differential diagnoses of chronic endometritis include:

• Endometriosis
• Adenomyosis
• Chronic endometritis

Other conditions that may be considered as differential diagnoses for non-specific chronic endometritis include:

• Fibroids: Non-cancerous growths in the uterus that can cause heavy bleeding and pelvic pain.
• Polyps: Growths on the surface of the cervix or uterus that can cause abnormal bleeding and pelvic pain.
• Cervical stenosis: A narrowing of the cervical canal that can cause difficulty with menstrual flow and pelvic pain.

It is essential to note that a definitive diagnosis of non-specific chronic endometritis requires histological examination and immunohistochemistry (IHC) for CD138.

References:

• Search result [4]
• Search result [10]